| Name | tumor necrosis factor alpha |
|---|---|
| Synonyms | Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19617896 | Wang HD, Lu XX, Lu DX, Qi RB, Wang YP, Fu YM, Wang LW: inhibits the LPS-induced increase in cytosolic Ca2+ concentration and TNFalpha production in cardiomyocytes by activating a glycine receptor. Acta Pharmacol Sin. 2009 Aug;30(8):1107-14. Epub 2009 Jul 20. GLY did not inhibit TNFalpha production induced by LPS at concentrations below 10 ng/mL but did significantly decrease TNFalpha release stimulated by 100 microg/mL LPS and prevented an LPS-induced increase in [Ca2+] c, which was reversed by strychnine, a glycine receptor antagonist. |
5(0,0,0,5) | Details |
| 10564180 | Wheeler MD, Thurman RG: Production of and TNF-alpha from alveolar macrophages is blunted by Am J Physiol. 1999 Nov;277(5 Pt 1):L952-9. blunts lipopolysaccharide (LPS)-induced increases in intracellular concentration ([Ca (2+)](i)) and tumor necrosis factor-alpha (TNF-alpha) production by Kupffer cells through a -gated chloride channel. Like the -gated chloride channel in the central nervous system, the effects of on [Ca (2+)](i) were both strychnine sensitive and dependent. |
1(0,0,0,1) | Details |
| 15730916 | Zhang SJ, Shi JH, Tang Z, Wu Y, Chen S: Protective effects of pretreatment on brain-death donor liver. . Hepatobiliary Pancreat Dis Int. 2005 Feb;4(1):37-40. METHODS: Fourty-two male Wistar rats were randomly divided into brain-death donor (BDD) group (B), pretreatment group with BDD (G), and strychnine pretreatment group with BDD (S). Before cold rinsing at 2 and 6 hours after portal vein (PV) reperfusion, blood samples were taken from infrahepatic vena cava (IHVC) to determine the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor alpha (TNF-alpha) and (HA). |
1(0,0,0,1) | Details |
| 10064624 | Spittler A, Reissner CM, Oehler R, Gornikiewicz A, Gruenberger T, Manhart N, Brodowicz T, Mittlboeck M, Boltz-Nitulescu G, Roth E: Immunomodulatory effects of on LPS-treated monocytes: reduced TNF-alpha production and accelerated IL-10 expression. FASEB J. 1999 Mar;13(3):563-71. Proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) stimulate the progression of septic shock whereas the anti-inflammatory cytokine IL-10 has counterregulative potency. The inhibitory effects of GLY were neutralized by strychnine, and the production of IL-10 and TNF-alpha was augmented by anti-IL-10 antibodies. |
1(0,0,0,1) | Details |
| 9227496 | Ikejima K, Qu W, Stachlewitz RF, Thurman RG: Kupffer cells contain a -gated chloride channel. . Am J Physiol. 1997 Jun;272(6 Pt 1):G1581-6. Low concentrations of strychnine (1 microM), a glycine receptor antagonist, reversed the inhibitory effect of completely; however, high concentrations of strychnine (1 mM) mimicked Moreover, tumor necrosis factor-alpha (TNF-alpha) production in cultured Kupffer cells due to LPS was decreased significantly by |
1(0,0,0,1) | Details |
| 9823766 | Seabra V, Stachlewitz RF, Thurman RG: blunts LPS-induced increases in intracellular and TNF-alpha production by Kupffer cells. J Leukoc Biol. 1998 Nov;64(5):615-21. LPS-induced changes in [Ca2+] i were monitored fluorometrically in single cells, whereas levels of tumor necrosis factor alpha (TNF-alpha) released by Kupffer cells after exposure to LPS were measured by enzyme-linked immunosorbent assay. This effect was reversed by strychnine (1 microM) and was prevented when was removed from the extracellular media. |
1(0,0,0,1) | Details |
| 11500467 | Li X, Bradford BU, Wheeler MD, Stimpson SA, Pink HM, Brodie TA, Schwab JH, Thurman RG: Dietary prevents peptidoglycan polysaccharide-induced reactive arthritis in the rat: role for -gated chloride channel. Infect Immun. 2001 Sep;69(9):5883-91. The inhibitory effect of was reversed by low concentrations of strychnine or -free buffer, and it increased radiolabeled influx nearly fourfold, an effect also inhibited by strychnine. |
0(0,0,0,0) | Details |