| 10200202 |
Rosenzweig S, Yan W, Dasso M, Spielman AI: Possible novel mechanism for bitter taste mediated through cGMP. . J Neurophysiol. 1999 Apr;81(4):1661-5.
In response to the bitter stimulants, caffeine and theophylline but not strychnine or denatonium cGMP levels demonstrated a rapid and transient increase that peaked at 50 ms and gradually declined throughout the following 4.5 s.
The proposed mechanism for this novel cGMP-mediated bitter taste signal transduction is cGMP production partially by the soluble GC and caffeine-induced inhibition of one or several phosphodiesterases. |
1(0,0,0,1) |
Details |