| Name | phospholipase C |
|---|---|
| Synonyms | PLC L; PLCE; PLC L (PLC epsilon); PLCL; PLCL 1; PLCL1; PLDL 1; PLDL1… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10974307 | Chen J, Heinke B, Sandkuhler J: Activation of group I metabotropic glutamate receptors induces long-term depression at sensory synapses in superficial spinal dorsal horn. Neuropharmacology. 2000 Sep;39(12):2231-43. In the presence of bicuculline and strychnine, bath application of (1S,3R)-1-aminocyclopentane-1, 3-dicarboxylic acid ((1S,3R)-ACPD) or the specific group I mGluR agonist (S)-3,5-dihydroxyphenylglycine ((S)-3,5- but not the specific group II mGluR agonist (2S,2'R,3'R)-2-(2', 3'-dicarboxycyclopropyl) (DCG-IV) for 20 min produced an acute and a long-term depression of synaptic strength. The phospholipase C inhibitor U73122 stereoselectively blocked the induction of long-term depression without affecting acute synaptic inhibition. |
2(0,0,0,2) | Details |
| 8728878 | Wikinski SI, Acosta GB: [Role of excitatory amino acids in neuropathology] . Medicina (B Aires). 1995;55(4):355-65. Along with the site for which binds and/or there have been identified a site for the binding of (which is different from the strychnine sensitive one), a site for poliamines such as and and a site for the binding of Zn2+ (Table 1). Both are coupled to a G protein and agonists exert their action increasing phospholipase C activity which in turn induces an increment of IP3 and diacyl-glicerol, and a consecutive releasing of Ca2+ from intracellular stores. |
1(0,0,0,1) | Details |
| 7878084 | Spielman AI, Huque T, Nagai H, Whitney G, Brand JG: Generation of inositol phosphates in bitter taste transduction. Physiol Behav. 1994 Dec;56(6):1149-55. Given the results from the immunoblots and those of the toxin experiments, it is proposed that the transduction of the bitter taste of octaacetate in mice involves a receptor-mediated activation of a Gi-type protein which activates a phospholipase C to produce the two second messengers, IP3 and DAG. |
1(0,0,0,1) | Details |
| 17567469 | Yamashina S, Ikejima K, Rusyn I, Sato N: as a potent anti-angiogenic nutrient for tumor growth. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1:S62-4. Further, the inhibitory effects of were prevented by low concentrations of strychnine (1 micromol/L) or incubation with -free buffer. Activation of VEGF receptor has been shown to result in activation of phospholipase C-gamma and increases in intracellular Ca (2+) concentration. |
1(0,0,0,1) | Details |
| 17317016 | Ishibashi H, Jang IS, Nabekura J: High potassium-induced facilitation of release from presynaptic terminals on mechanically dissociated rat spinal dorsal horn neurons in the absence of extracellular Neuroscience. 2007 Apr 25;146(1):190-201. Epub 2007 Feb 20. The action of high potassium solution on release was prevented by BAPTA-AM, by depletion of intracellular Ca2+ stores by thapsigargin and by the phospholipase C inhibitor U-73122. |
1(0,0,0,1) | Details |
| 8845730 | Heilbronn E, Jarlebark L, Lawoko G: Cholinergic and purinergic signalling in outer hair cells of mammalian cochlea. Neurochem Int. 1995 Oct-Nov;27(4-5):301-11. Strychnine, a glycine receptor blocker suggested to interfere with cholinergic sites of the efferent OHC synapse, was found to bind to OHC (cold strychnine for unspecific binding). |
0(0,0,0,0) | Details |