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Qu W, Ikejima K, Zhong Z, Waalkes MP, Thurman RG: Glycine blocks the increase in intracellular free Ca2+ due to vasoactive mediators in hepatic parenchymal cells. Am J Physiol Gastrointest Liver Physiol. 2002 Dec;283(6):G1249-56. Epub 2002 Aug 14.
Low-dose strychnine, an antagonist of glycine-gated chloride channel in the central nervous system, partially reversed the inhibition by glycine.
Liver parenchymal cells isolated from female Sprague-Dawley rats were cultured for 4 h in DMEM/F12 medium, and [Ca (2+)](i) in individual cells was assessed fluorometrically using the fluorescent calcium indicator fura 2. |
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