| Name | alpha 1 acid glycoprotein |
|---|---|
| Synonyms | AGP 1; ORM; AGP A; AGP1; Alpha 1 acid glycoprotein; Alpha 1 AGP; Alpha 1 acid glycoprotein 1; Alpha 1 acid glycoprotein 1 precursor… |
| Name | warfarin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19198000 | Nishi K, Ueno M, Murakami Y, Fukunaga N, Akuta T, Kadowaki D, Watanabe H, Suenaga A, Maruyama T, Otagiri M: A site-directed mutagenesis study of drug-binding selectivity in genetic variants of human alpha (1)-acid glycoprotein. J Pharm Sci. 2009 Nov;98(11):4316-26. First, we screened amino acid residues in the region proximal to position 100 that are involved in binding of warfarin and dipyridamole, which are F1*S-specific ligands, and of propafenone, which is an A-specific ligand, using ultrafiltration. |
2(0,0,0,2) | Details |
| 18269390 | Reine PA, Kongsgaard UE, Andersen A, Thogersen AK, Olsen H: Infusion of albumin attenuates changes in serum protein binding of drugs in surgical patients compared with volume replacement with HAES. Acta Anaesthesiol Scand. 2008 Mar;52(3):406-12. The serum samples were analyzed to determine the concentrations of albumin, N-acetyl-dl- and alpha-1-acid glycoprotein as well as in vitro drug binding of warfarin and digitoxin. |
81(1,1,1,1) | Details |
| 19338267 | Sandblad P, Arnell R, Samuelsson J, Fornstedt T: Approach for reliable evaluation of drug proteins interactions using surface plasmon resonance technology. Anal Chem. 2009 May 1;81(9):3551-9. Both the binding of the chiral beta-blocker to alpha (1)-acid glycoprotein (AGP) and that of the anticoagulant warfarin to human serum albumin were heterogeneous, with a few strong enantioselective sites and many weak nonselective sites. |
31(0,1,1,1) | Details |
| 19958090 | Lee MT, Chen CH, Chou CH, Lu LS, Chuang HP, Chen YT, Saleem AN, Wen MS, Chen JJ, Wu JY, Chen YT: Genetic determinants of warfarin dosing in the Han-Chinese population. Pharmacogenomics. 2009 Dec;10(12):1905-13. MATERIALS & METHODS: In this study, we screened for SNPs in 13 genes (VKORC1, CYP2C9, CYP2C18, PROC, APOE, EPHX1, CALU, GGCX, ORM1, ORM2, factor VII and CYP4F2) and tested their associations with warfarin dosing with univariate and multiple regression analysis. |
6(0,0,1,1) | Details |
| 18680736 | Wang TL, Li HL, Tjong WY, Chen QS, Wu GS, Zhu HT, Hou ZS, Xu S, Ma SJ, Wu M, Tai S: Genetic factors contribute to patient-specific warfarin dose for Han Chinese. Clin Chim Acta. 2008 Oct;396(1-2):76-9. Epub 2008 Jul 12. |
0(0,0,0,0) | Details |