Protein Information

Name progesterone receptor
Synonyms NR3C3; PGR; PR; Progesterone receptor; Progesterone receptors

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
18992306 Li J, Li N, Ma M, Giesy JP, Wang Z: In vitro profiling of the endocrine disrupting potency of organochlorine pesticides. Toxicol Lett. 2008 Dec 15;183(1-3):65-71. Epub 2008 Oct 17.

The objectives of this study were to determine and compare the ability of p,p'-dichlorodiphenylethane (p,p'-DDE), p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT), hexachlorobenzene (HCB) and r-hexachlorocyclohexane (r-HCH) to interact with ERalpha, androgen receptor (AR), progesterone receptor (PR) and estrogen-related receptor (ERRgamma) using a set of recombined yeast strains expressing beta-galactosidase, under control of ERalpha, AR, PR or ERRgamma.
81(1,1,1,1) Details
16859517 Munoz-de-Toro M, Durando M, Beldomenico PM, Beldomenico HR, Kass L, Garcia SR, Luque EH: Estrogenic microenvironment generated by organochlorine residues in adipose mammary tissue modulates biomarker expression in ERalpha-positive breast carcinomas. Breast Cancer Res. 2006;8(4):R47.

The most frequently detected compounds were p,p'-dichlorodiphenyldichloroethylene, hexachlorobenzene and beta-hexachlorocyclohexane.
Estrogen receptor alpha (ERalpha), progesterone receptor (PR) and proliferative activity (Ki-67) levels were measured in paraffin-embedded biopsies of breast tumors by immunohistochemistry.
1(0,0,0,1) Details
10350435 Zheng T, Holford TR, Mayne ST, Tessari J, Owens PH, Zahm SH, Zhang B, Dubrow R, Ward B, Carter D, Boyle P: Environmental exposure to hexachlorobenzene (HCB) and risk of female breast cancer in Connecticut. Cancer Epidemiol Biomarkers Prev. 1999 May;8(5):407-11.

0(0,0,0,0) Details