| Name | aryl hydrocarbon hydroxylase |
|---|---|
| Synonyms | Aryl hydrocarbon hydroxylase; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CP37; CYP3A7; CYPIIIA 7; CYPIIIA7… |
| Name | hexachlorobenzene |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorobenzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6286155 | Goldstein JA, Linko P, Huckins JN, Stalling DL: Structure-activity relationships of chlorinated benzenes as inducers of different forms of cytochrome P-450 in rat liver. Chem Biol Interact. 1982 Aug;41(2):131-9. Hexachlorobenzene (HCB) produced increases in ethoxyresorufin (ERR) O-deethylase, aryl hydrocarbon hydroxylase (AHH) and aminopyrine N-demethylase activities in rat liver phenobarbital which were intermediate between those produced by phenobarbital and 3,4-benzpyrene (BP), alpha-Naphthoflavone (ANF) selectivity inhibited ERR activity in BP and HCB-induced microsomes (94% and 88%). |
31(0,1,1,1) | Details |
| 3596752 | Li SM, Denomme MA, Leece B, Safe S, Dutton D, Parkinson A, Thomas PE, Ryan D, Bandiera S, Reik LM, et al.: Hexachlorobenzene and substituted pentachlorobenzenes (X-C6Cl5) as inducers of hepatic cytochrome P-450-dependent mono-oxygenases. IARC Sci Publ. 1986;(77):527-34. Hexachlorobenzene (HCB) and 2,3,4,4',5-pentachlorobiphenyl induced a similar spectrum of cytochrome-P-450-dependent mono-oxygenase activities in the rat, including 4-dimethylaminoantipyrine N-demethylase, aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin O-deethylase (EROD). |
6(0,0,1,1) | Details |
| 4043593 | Jansing RL, Shain W: Aryl hydrocarbon hydroxylase induction in adult rat hepatocytes in primary culture by several chlorinated aromatic hydrocarbons including 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol. 1985 Aug;5(4):713-20. AHH induction was extremely sensitive to two planar polyaromatic hydrocarbons, 2,3,7,8-TCDD and 2,3,7,8-tetrachlorodibenzofuran, and the PCB congener 3,4,3',4'-tetrachlorobiphenyl, but insensitive to 2,6-dichlorodibenzofuran, 2,5,2',5'-tetrachlorobiphenyl, 2,4,5,2',4',5'-hexachlorobiphenyl, and hexachlorobenzene. |
2(0,0,0,2) | Details |
| 3236339 | Rizzardini M, Graziani A, Carugo C, Cantoni L: Investigations on the role of free radical processes in hexachlorobenzene-induced porphyria in mice. J Biochem Toxicol. 1988 Spring;3:33-45. The combined treatment resulted in a significant reduction of HCB's inductive effects on microsomal heme and cytochromes P-450 and b5 and on the activity of aryl hydrocarbon hydroxylase. |
1(0,0,0,1) | Details |
| 3629612 | Cantoni L, Rizzardini M, Tacconi MT, Graziani A: Comparison of hexachlorobenzene-induced alterations of microsomal membrane composition and monooxygenase activity in male and female rats. Toxicology. 1987 Sep;45(3):291-305. Analysis of patterns of induction of microsomal monooxygenases showed that aminopyrine-N-demethylase activity doubled in both sexes after treatment while aryl hydrocarbon hydroxylase activity was 16 times the control value in the females and 1.5 times in the males. |
1(0,0,0,1) | Details |
| 7126264 | Holme JA, Dybing E: Induction of liver microsomal cytochrome P-450 and associated monooxygenases by octachlorostyrene in inbred strains of mice. Biochem Pharmacol. 1982 Aug 1;31(15):2523-9. Single intraperitoneal injections of octachlorostyrene (OCS) and hexachlorobenzene in genetically polycyclic aromatic hydrocarbon "responsive' C57/BL/6 (B6) mice led to a time- and dose-dependent increase in the levels of liver microsomal cytochromes P-450 and b5 as well as in the activities of cytochrome P-450 (cytochrome c) reductase, ethylmorphine (EM) N-demethylase, 4-nitroanisole (PNA) O-demethylase and acetanilide 4-hydroxylase (AcA hydroxylase). No, or only a very moderate, increase in the activity of aryl hydrocarbon hydroxylase was seen after OCS and HCB, respectively. |
1(0,0,0,1) | Details |
| 3981666 | Carpenter HM, Williams DE, Buhler DR: A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail. J Toxicol Environ Health. 1985;15(1):93-108. However, a differential response to HCB and BNF treatment was seen in the activities of hepatic -cytochrome P-450 reductase, epoxide hydrolase, GSH-t (microsomal), aryl hydrocarbon hydroxylase (AHH), and ethoxycoumarin O-deethylase (ECOD). |
1(0,0,0,1) | Details |
| 4032490 | Carpenter HM, Williams DE, Buhler DR: Hexachlorobenzene-induced porphyria in Japanese quail: changes in microsomal enzymes. J Toxicol Environ Health. 1985;15(3-4):431-44. Changes included elevation of microsomal protein concentrations and increases in the specific content of cytochrome P-450, in the activities of aryl hydrocarbon hydroxylase (AHH), biphenyl hydroxylase (BPH), ethoxyresorufin-O-deethylase (EROD), and ethoxycoumarin-O-deethylase (ECOD), and in cytosolic and microsomal glutathione S-transferase (GSH-t) levels. |
1(0,0,0,1) | Details |
| 3952775 | Rozman K, Gorski JR, Rozman P, Parkinson A: Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. Toxicol Lett. 1986 Jan;30(1):71-8. |
0(0,0,0,0) | Details |