| Name | IgE |
|---|---|
| Synonyms | IGHE; Ig epsilon chain C region; IgE; immunoglobulin heavy constant epsilon; Ig epsilon chain C regions; IgEs; immunoglobulin heavy constant epsilons |
| Name | hexachlorobenzene |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorobenzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15831097 | Karmaus W, Brooks KR, Nebe T, Witten J, Obi-Osius N, Kruse H: Immune function biomarkers in children exposed to lead and organochlorine compounds: a cross-sectional study. Environ Health. 2005 Apr 14;4(1):5. METHODS: We investigated whether the organochlorine compounds (OC) dichlorodiphenylethylene (DDE), hexachlorobenzene (HCB), hexachlorocyclohexane (gamma-HCH), the sum of polychlorinated biphenyls (SigmaPCBs) and Pb were associated with immune markers such as immunoglobulin (Ig) levels, white blood cell (WBC), counts of lymphocytes; eosinophils and their eosinophilic granula as well as IgE count on basophils. |
9(0,0,1,4) | Details |
| 14657514 | Ezendam J, Hassing I, Bleumink R, Vos JG, Pieters R: Hexachlorobenzene-induced Immunopathology in Brown Norway rats is partly mediated by T cells. Toxicol Sci. 2004 Mar;78(1):88-95. Epub 2003 Dec 2. The Brown Norway (BN) rat is very susceptible to HCB-induced immunopathology, and oral exposure causes inflammatory skin and lung lesions, splenomegaly, lymph node (LN) enlargement, and increased serum levels of IgE and anti-ssDNA IgM. |
2(0,0,0,2) | Details |
| 16330365 | Sunyer J, Torrent M, Munoz-Ortiz L, Ribas-Fito N, Carrizo D, Grimalt J, Anto JM, Cullinan P: Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children. Environ Health Perspect. 2005 Dec;113(12):1787-90. We measured specific immunoglobulin-E (IgE) against house dust mite, cat, and grass in sera extracted at 4 years of age. DDE (median = 1.03 ng/mL) was detected in all children, as well as hexachlorobenzene (0.68 ng/mL) and polychlorobiphenyls (0.69 ng/mL). |
1(0,0,0,1) | Details |
| 11264018 | Michielsen CP, Leusink-Muis A, Vos JG, Bloksma N: Hexachlorobenzene-induced eosinophilic and granulomatous lung inflammation is associated with in vivo airways hyperresponsiveness in the Brown Norway rat. Toxicol Appl Pharmacol. 2001 Apr 1;172(1):11-20. Prolonged HCB exposure for 21 days resulted in severe and extensive eosinophilic and granulomatous lung inflammation, a threefold increase of total serum IgE levels, and marked cholinergic AHR in all rats. |
1(0,0,0,1) | Details |
| 11119253 | Vandebriel RJ, Meredith C, Scott MP, van Dijk M, van Loveren H: Interleukin-10 is an unequivocal Th2 parameter in the rat, whereas interleukin-4 is not. Scand J Immunol. 2000 Nov;52(5):519-24. In HCB exposed Lewis rats and T. spiralis infected BN rats the IL-4 mRNA expression correlated with IgE levels and T. spiralis infection, respectively, whereas the IL-4 production lacked correlation in all cases. Exposure of Wistar rats to the immunotoxic compounds hexachlorobenzene (HCB), bis (tri-n-butyltin) oxide, and benzo (a) pyrene was previously found to affect mRNA expression of interleukin (IL)-2, IL-2R alpha-chain, and interferon (IFN)-gamma, the prototypic Th1 cytokine. |
1(0,0,0,1) | Details |
| 16289241 | Noakes PS, Taylor P, Wilkinson S, Prescott SL: The relationship between persistent organic pollutants in maternal and neonatal tissues and immune responses to allergens: A novel exploratory study. Chemosphere. 2006 May;63(8):1304-11. Epub 2005 Nov 10. POPs have been detected in human cord blood, placental tissues and breast milk, and the reported association between cord blood IgE levels and cord/placental POP levels has raised concerns about potential immunological effects in early life. Gas chromatography was used to detect polychlorinated biphenyl compounds [PCBs] (as Aroclor 1232, 1254, 1260) and organochlorine (OC) pesticides, including p,p'-DDT, p,p'-DDE, hexachlorobenzene (HCB), lindane, heptachlor epoxide, dieldrin and chlordane. |
1(0,0,0,1) | Details |
| 16271622 | Ezendam J, Kosterman K, Spijkerboer H, Bleumink R, Hassing I, van Rooijen N, Vos JG, Pieters R: Macrophages are involved in hexachlorobenzene-induced adverse immune effects. Toxicol Appl Pharmacol. 2005 Nov 15;209(1):19-27. The Brown Norway (BN) rat is very susceptible to HCB-induced immunopathology and oral exposure causes inflammatory skin and lung lesions, splenomegaly, lymph node (LN) enlargement, and increased serum levels of IgE and anti-ssDNA IgM. |
1(0,0,0,1) | Details |
| 9169065 | Michielsen CP, Bloksma N, Ultee A, van Mil F, Vos JG: Hexachlorobenzene-induced immunomodulation and skin and lung lesions: a comparison between brown Norway, Lewis, and Wistar rats. Toxicol Appl Pharmacol. 1997 May;144(1):12-26. Serum IgE and IgG levels were increased significantly in a dose-dependent way in BN rats only. |
1(0,0,0,1) | Details |