| PubMed |
Abstract |
RScore(About this table) |
| 12732362 |
Randi AS, Sancovich HA, Ferramola de Sancovich AM, Loaiza A, Kolliker Frers RA, Spinelli F, Kleiman de Pisarev DL: Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver. Biochem Pharmacol. 2003 May 1;65(9):1495-506.
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7(0,0,1,2) |
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| 14600289 |
Randi AS, Hernandez S, Alvarez L, Sanchez M, Schwarcz M, Kleiman d Pisarev DL: Hexachlorobenzene-induced early changes in ornithine decarboxylase and protein tyrosine kinase activities, polyamines and c-Myc, c-Fos and c-Jun proto-oncogenes in rat liver. Toxicol Sci. 2003 Dec;76(2):291-8. Epub 2003 Nov 4.
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7(0,0,1,2) |
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| 16237195 |
Randi AS, Cocca C, Carbone V, Nunez M, Croci M, Gutierrez A, Bergoc R, Kleiman de Pisarev DL: Hexachlorobenzene is a tumor co-carcinogen and induces alterations in insulin-growth factors signaling pathway in the rat mammary gland. Toxicol Sci. 2006 Jan;89(1):83-92. Epub 2005 Oct 19.
The aims of this study were to determine: (1) whether HCB is co-carcinogenic in a medium term assay of N-nitroso N-methylurea (NMU)-induced mammary tumors in rats; (2) the effect of HCB on insulin receptor (IR), insulin-like growth factor-I receptor (IGF-IR) and insulin receptor substrate-1 (IRS-1) levels and on IRS-1 phosphorylation; (3) microsomal and cytosolic Protein Tyrosine Kinase (PTK) activities in mammary glands and NMU-induced tumors. |
1(0,0,0,1) |
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| 9570324 |
Randi AS, Sancovich HA, Ferramola de Sancovich AM, Loaiza A, Krawiec L, Kleiman de Pisarev DL: Hexachlorobenzene-induced alterations of rat hepatic microsomal membrane function. Toxicology. 1998 Feb 6;125(2-3):83-94.
HCB was found to cause a significant rise in protein tyrosine kinase (PTK) activity during the early stages of intoxication (day 2), followed by a significant decrease at 10 days, returning to control levels after 20 days of treatment. |
1(0,0,0,1) |
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