| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | monocrotophos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6710541 | Gupta M, Bagchi GK, Gupta SD, Sasmal D, Chatterjee T, Dey SN: Changes of catecholamines and amino acid in mice brain following treatment with Nuvacron and Furadan. Toxicology. 1984 Mar;30(2):171-5. The following were measured: acetylcholinesterase, and |
2(0,0,0,2) | Details |
| 17436543 | Agrahari S, Gopal K, Pandey KC: Biomarkers of monocrotophos in a freshwater fish Channa punctatus (Bloch). J Environ Biol. 2006 May;27(2 Suppl):453-7. Biomarkers such as total protein, lipid peroxidation and acetylcholinesterase have been measured in different tissues of fish viz. gills, liver, brain and muscles. |
2(0,0,0,2) | Details |
| 20026515 | Dwivedi N, Bhutia YD, Kumar V, Yadav P, Kushwaha P, Swarnkar H, Flora SJ: Effects of combined exposure to dichlorvos and monocrotophos on blood and brain biochemical variables in rats. Hum Exp Toxicol. 2010 Feb;29(2):121-9. Epub 2009 Dec 21. We studied the effect of concomitant exposure to DDVP and MC on selected biochemical variables suggestive of liver damage, changes in whole brain biogenic amines levels, acetylcholinesterase (AchE) and monoamine oxidase (MAO) activities in rats. |
2(0,0,0,2) | Details |
| 10641186 | Rahman MF, Siddiqui MK, Jamil K: Biochemical alterations induced by a new phosphorothionate (RPR-II) in tissues of male and female rats. Indian J Exp Biol. 1999 Jun;37(6):546-52. This study was conducted to investigate the effect of a new phosphorothionate, the methyl ester of 2-butenoic acid-3-diethoxy phosphinothioyl (RPR-II) on membrane bound target enzymes amino transferase (ASAT), amino transferase (ALAT) and RBC acetylcholinesterase (AChE) in different tissues of male and female albino wistar rats when treated orally with 0.014 (low), 0.028 (medium) and 0.042 (high) mg/kg daily for a period of 90 days. |
2(0,0,0,2) | Details |
| 16730777 | Rao JV: Biochemical alterations in euryhaline fish, Oreochromis mossambicus exposed to sub-lethal concentrations of an organophosphorus insecticide, monocrotophos. Chemosphere. 2006 Dec;65(10):1814-20. Epub 2006 May 30. Alanine aminotransferase (ALAT), aspartate aminotransferase (AAT), acid phosphatase (AcP), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), (GSH), gluthathione-S-transferase (GST) and acetylcholinesterase (AChE), were assayed in plasma and different tissues at regular intervals of day -3, -7, -15, -30 and after recovery period of seven days. |
1(0,0,0,1) | Details |
| 11681666 | Maklakov A, Ishaaya I, Freidberg A, Yawetz A, Horowitz AR, Yarom I: Toxicological studies of organophosphate and pyrethroid insecticides for controlling the fruit fly Dacus ciliatus (Diptera: Tephritidae). J Econ Entomol. 2001 Oct;94(5):1059-66. This was supported by the insignificant decrease of head acetylcholinesterase activity. |
1(0,0,0,1) | Details |
| 847753 | Pickering CE, Pickering RG: The interference by erythrocyte "acetylthiocholinesterase" in the estimation of the blood cholinesterase activity of the chicken. Toxicol Appl Pharmacol. 1977 Feb;39(2):229-37. |
1(0,0,0,1) | Details |
| 12654229 | Hou Y, Fu F, Liu S, Liu C, Sun Y, Qiu S: [The profiles of free organophosphorus poisons in the bile of rabbits poisoned with different organophosphates]. Zhonghua Nei Ke Za Zhi. 2002 Dec;41(12):795-7. METHODS: Seventy two livid blue rabbits, male, 2 - 2.5 kg in weight, were divided into 3 groups: trichlorfon (556.0 mg/kg), monocrotophos (11.12 mg/kg) and methyl parathion (37.05 mg/kg). Acetylcholinesterase (AChE) activity was measured with dithiobisnitrobenzoic acid (DTNB) enzyme kinetic method. |
1(0,0,0,1) | Details |
| 16765096 | Venkateswara Rao J: Sublethal effects of an organophosphorus insecticide (RPR-II) on biochemical parameters of tilapia, Oreochromis mossambicus. Comp Biochem Physiol C Toxicol Pharmacol. 2006 Aug;143(4):492-8. Epub 2006 May 10. Acetylcholinesterase (AChE) activity of brain, gill and muscle was inhibited by 67%, 77% and 73% respectively on day-30. |
1(0,0,0,1) | Details |
| 15793557 | Isoda H, Talorete TP, Han J, Oka S, Abe Y, Inamori Y: Effects of organophosphorous pesticides used in china on various mammalian cells. Environ Sci. 2005;12(1):9-19. Five organophosphorous pesticides, monocrotophos, omethoate, parathion-methyl, phoxim and dichlorvos, were examined for their effects on mammalian cell lines to determine their potential impact on physiological functions in vivo. The different pesticides reduced the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 in a dose-dependent manner up to 100 microM. |
1(0,0,0,1) | Details |
| 19908228 | Carletto J, Martin T, Vanlerberghe-Masutti F, Brevault T: Insecticide resistance traits differ among and within host races in Aphis gossypii. Pest Manag Sci. 2010 Mar;66(3):301-7. Conversely, all clones were resistant to dimethoate (organophosphate) (RF = 4.1-38.1) and carried mutation S431F in the acetylcholinesterase gene. Auber, PsP4 and Burk also carried mutation A302S in this gene, which possibly conferred moderate resistance (RF = 3.7-6.8) to profenofos and monocrotophos (organophosphates). |
1(0,0,0,1) | Details |
| 17549541 | Venkateswara Rao J, Kavitha P, Jakka NM, Sridhar V, Usman PK: Toxicity of organophosphates on morphology and locomotor behavior in brine shrimp, Artemia salina. Arch Environ Contam Toxicol. 2007 Aug;53(2):227-32. Epub 2007 Jun 1. The acute toxicity and hatching success of four organophosphorus insecticides--acephate (ACEP), chlorpyrifos (CPP), monocrotophos (MCP), and profenofos (PF)--was studied in a short-term bioassay using brine shrimp, Artemia salina. The in vivo effect of these insecticides on acetylcholinesterase (Enzyme commission number (EC 3.1.1.7) activity was also determined in LC (50)-exposed nauplii after 24 hours. |
1(0,0,0,1) | Details |
| 9619645 | Singh G, Mahajan R, Whig J: The importance of electrodiagnostic studies in acute organophosphate poisoning. J Neurol Sci. 1998 May 7;157(2):191-200. Electrodiagnostic studies revealed single stimulus induced repetitive responses and decrement-increment responses at 30 and 50 Hz repetitive nerve stimulation, findings that are indicative of a depolarization block due to inactivation of acetylcholinesterase at the motor end-plate. |
1(0,0,0,1) | Details |
| 3403919 | Siddiqui MK, Rahman MF, Mahboob M, Anjum F, Mustafa M: Species differences in brain acetylcholinesterase and neuropathic target esterase response to monocrotophos. J Environ Sci Health B. 1988 Jun;23(3):291-9. |
164(2,2,2,4) | Details |
| 1868785 | Siddiqui MK, Rahman MF, Mustafa M, Rahman MF, Bhalerao UT: A comparative study of blood changes and brain acetylcholinesterase inhibition by monocrotophos and its analogues in rats. Ecotoxicol Environ Saf. 1991 Jun;21(3):283-9. |
162(2,2,2,2) | Details |
| 16872049 | Singh M, Sandhir R, Kiran R: Erythrocyte antioxidant enzymes in toxicological evaluation of commonly used organophosphate pesticides. Indian J Exp Biol. 2006 Jul;44(7):580-3. Present work is designed to study the in vitro effects of some organophosphates (ethion, chlorpyrifos, dimethoate and monocrotophos) on rat erythrocytes. Membrane bound enzymes like acetylcholinesterase (AChE), Na (+)-K (+)-ATPase and Ca (2+)-ATPase were also inhibited. |
1(0,0,0,1) | Details |
| 12602824 | Rahman MF, Siddiqui MK: Biochemical enzyme activity in different tissues of rats exposed to a novel phosphorothionate (RPR-V). J Environ Sci Health B. 2003 Jan;38(1):59-71. This compound also caused significant inhibition of RBC Acetylcholinesterase, target enzyme of organophosphorus compounds revealing its effect on normal synaptic transmission. |
1(0,0,0,1) | Details |
| 15058652 | Rahman MF, Mahboob M, Grover P: In vitro acetylcholinesterase inhibition by novel OP compounds in various tissues of the fish Channa punctatus. Bull Environ Contam Toxicol. 2004 Jan;72(1):38-44. |
1(0,0,0,1) | Details |
| 7643964 | Thangnipon W, Thangnipon W, Luangpaiboon P, Chinabut S: Effects of the organophosphate insecticide, monocrotophos, on acetylcholinesterase activity in the nile tilapia fish (Oreochromis niloticus) brain. Neurochem Res. 1995 May;20(5):587-91. The results indicate that inhibition of AChE activity in fish exposed to monocrotophos may serve as an indicator of hazard due to application of this chemical in the natural environment. |
124(1,2,4,4) | Details |
| 15751007 | Venkateswara Rao J, Parvathi K, Kavitha P, Jakka NM, Pallela R: Effect of chlorpyrifos and monocrotophos on locomotor behaviour and acetylcholinesterase activity of subterranean termites, Odontotermes obesus. Pest Manag Sci. 2005 Apr;61(4):417-21. At all time intervals the chlorpyrifos-treated termites exhibited more AChE inhibition and showed greater distorted behaviour than those exposed to monocrotophos. |
119(1,2,3,4) | Details |
| 7523071 | Qadri YH, Swamy AN, Rao JV: Species differences in brain acetylcholinesterase response to monocrotophos in vitro. Ecotoxicol Environ Saf. 1994 Jun;28(1):91-8. The following investigation was designed to determine if species-related differences in the sensitivity of brain AChE to inhibition by monocrotophos (MCP) could contribute to the interspecies differences in toxicity. |
92(1,1,2,7) | Details |
| 15454122 | Garg UK, Pal AK, Jha GJ, Jadhao SB: Haemato-biochemical and immuno-pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides in broiler chicks. Int Immunopharmacol. 2004 Dec 15;4(13):1709-22. Haemato- biochemical and immuno-pathophysiological changes following feeding of broiler chicks with 20 ppm fenvalerate (synthetic pyrethroid, SP), 2 ppm monocrotophos (organophosphate, OP) and 2 ppm endosulfan (chlorinated hydrocarbon, CH) were studied. |
0(0,0,0,0) | Details |
| 12386838 | Ren X, Han Z, Wang Y: Mechanisms of monocrotophos resistance in cotton bollworm, Helicoverpa armigera (Hubner). Arch Insect Biochem Physiol. 2002 Nov;51(3):103-10. Insensitive acetylcholinesterase was identified as a resistance mechanism by comparing biochemical analysis with a laboratory selected monocrotophos resistant cotton bollworm (RR: 200) and the susceptible strain. |
91(1,1,2,6) | Details |
| 20021020 | Das GP, Jamil K, Rahman MF: Effect of four organophosphorus compounds on human blood acetylcholinesterase: in vitro studies. Toxicol Mech Methods. 2006;16(8):455-9. The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitors of AChE. |
90(1,1,2,5) | Details |
| 1787264 | Rao JV, Swamy AN, Yamin S: In vitro brain acetylcholinesterase response among three inbred strains of mice to monocrotophos. J Environ Sci Health B. 1991 Aug;26(4):449-58. The strain differences in the potential of monocrotophos (MCP) were assessed by determining the inhibition of brain acetylcholinesterase (AChE) in BALB/cAnN, DBA/2J and C57BL/6J in vitro. |
88(1,1,2,3) | Details |
| 17590326 | Du D, Huang X, Cai J, Zhang A: Comparison of pesticide sensitivity by electrochemical test based on acetylcholinesterase biosensor. Biosens Bioelectron. 2007 Sep 30;23(2):285-9. Epub 2007 May 18. Four pesticides of carbaryl, malathion, dimethoate and monocrotophos were selected to discuss their inhibition efficiencies to AChE. |
85(1,1,1,5) | Details |
| 8783813 | Worek F, Kirchner T, Backer M, Szinicz L: Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. Arch Toxicol. 1996;70(8):497-503. For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. |
84(1,1,1,4) | Details |
| 16194919 | Rao JV, Begum G, Sridhar V, Reddy NC: Sublethal effects of monocrotophos on locomotor behavior and gill architecture of the mosquito fish, Gambusia affinis. J Environ Sci Health B. 2005;40(6):813-25. Subacute studies of monocrotophos [Dimethyl (E)-1-methyl-2-(methyl-carbamoyl) vinyl on mosquito fish, Gambusia affinis, were carried out in vivo for 24 days to assess the locomotor behavior, structural integrity of gill, and targeted enzyme acetylcholinesterase (AChE, EC: 3.1.1.7) interactions. |
84(1,1,1,4) | Details |
| 3323058 | Pilo B, Mehan SP: Effect of cholinesterase inhibitors on and insulin induced uptake and certain hepatic enzymes in pigeon liver: an in vitro study. Indian J Physiol Pharmacol. 1987 Jul-Sep;31(3):159-69. Monocrotophos, acothione (organophosphorus compound) and prostigmine are known inhibitors of acetylcholinesterase (AChE). |
83(1,1,1,3) | Details |
| 20021016 | Venkatesh S, Zachariah A, Oommen A: Myofibril membranes in relation to the neuromuscular weakness of acute monocrotophos poisoning. Toxicol Mech Methods. 2006;16(8):419-26. Increasing doses of monocrotophos inhibited brain and RBC acetylcholinesterase >/=60% early in the poisoning. |
82(1,1,1,2) | Details |
| 19437977 | Du D, Chen W, Cai J, Zhang J, Tu H, Zhang A: Acetylcholinesterase biosensor based on gold nanoparticles and self assembled monolayer for determination of monocrotophos. J Nanosci Nanotechnol. 2009 Apr;9(4):2368-73. In this paper, a simple method for immobilization of acetylcholinesterase (AChE) on assembled glassy carbon electrode coupled with gold nanoparticles (GNPs) was proposed and thus a sensitive, fast and stable amperometric biosensor for quantitative determination of monocrotophos was developed. |
43(0,1,3,3) | Details |
| 17499494 | Du D, Chen S, Cai J, Zhang A: Immobilization of acetylcholinesterase on gold nanoparticles embedded in sol-gel film for amperometric detection of organophosphorous insecticide. Biosens Bioelectron. 2007 Aug 30;23(1):130-4. Epub 2007 Mar 25. Based on the inhibition of organophosphorous insecticide on the enzymatic activity of AChE, using monocrotophos as a model compound, the conditions for detection of the insecticide were optimized. |
34(0,1,1,4) | Details |
| 20002213 | Kwon DH, Clark JM, Lee SH: Extensive gene duplication of acetylcholinesterase associated with organophosphate resistance in the two-spotted spider mite. Insect Mol Biol. 2009 Nov 25. Abstract Monocrotophos-resistant two-spotted spider mites (TSSMs), Tetranychus urticae, are known to possess three mutations on the acetylcholinesterase (AChE) gene (Tuace) that are involved in target site insensitivity. |
33(0,1,1,3) | Details |
| 18640026 | Du D, Chen S, Song D, Li H, Chen X: Development of acetylcholinesterase biosensor based on CdTe quantum dots/gold nanoparticles modified microspheres interface. Biosens Bioelectron. 2008 Nov 15;24(3):475-9. Epub 2008 May 27. Since GNPs have shown widespread use particularly for constructing electrochemical biosensors through their high electron-transfer ability, the combined AChE exhibited high affinity to its substrate and thus a sensitive, fast and cheap method for determination of monocrotophos. |
33(0,1,1,3) | Details |
| 15327878 | Rao JV: Effects of monocrotophos and its analogs in acetylcholinesterase activity's inhibition and its pattern of recovery on euryhaline fish, Oreochromis mossambicus. Ecotoxicol Environ Saf. 2004 Oct;59(2):217-22. |
33(0,1,1,3) | Details |
| 1417899 | Swamy KV, Ravikumar R, Mohan PM: Changes in cholinesterase system in different brain areas during the development of behavioral tolerance to monocrotophos toxicity in male albino rats. Biochem Int. 1992 Aug;27(4):661-9. During the development of behavioral tolerance to the organophosphate monocrotophos, the activities of AChE and BuChE and the content of were affected in different brain areas of male albino rats. |
14(0,0,2,4) | Details |
| 18569613 | Rajini PS, Melstrom P, Williams PL: A comparative study on the relationship between various toxicological endpoints in Caenorhabditis elegans exposed to organophosphorus insecticides. J Toxicol Environ Health A. 2008;71(15):1043-50. The toxicity of 10 organophophorus (OP) insecticides-acephate, dimethoate, dichlorvos, dicrotophos, monocrotophos, methamidophos, phosphamidon, omethoate, phosdrin, and trichlorfon-was evaluated in Caenorhabditis elegans using lethality, movement, and acetylcholinesterase (AChE) activity as the endpoints after a 4-hr- exposure period. |
9(0,0,1,4) | Details |
| 15171950 | Srinivas R, Udikeri SS, Jayalakshmi SK, Sreeramulu K: Identification of factors responsible for insecticide resistance in Helicoverpa armigera. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Mar;137(3):261-9. Acetylcholinesterase of resistant larvae was less sensitive to monocrotophos and methyl paraoxon. |
7(0,0,1,2) | Details |
| 11023690 | Rahman MF, Siddiqui MK, Jamil K: Inhibition of acetylcholinesterase and different ATPases by a novel phosphorothionate (RPR-II) in rat brain. Ecotoxicol Environ Saf. 2000 Oct;47(2):125-9. |
6(0,0,0,6) | Details |
| 17546082 | Chen MH, Han ZJ, Qiao XF, Qu MJ: Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and insecticides. Genome. 2007 Feb;50(2):172-9. Bioassays showed that the resistant strain used was highly or moderately resistant to pirimicarb, omethoate, and monocrotophos (resistance ratio, 263.8, 53.8, and 17.5, respectively), and showed little resistance to deltamethrin or thiodicarb (resistance ratio, 5.2 and 3.4, respectively). |
6(0,0,0,6) | Details |
| 1373663 | Rao JV, Swamy AN, Yamin S: Rat brain acetylcholinesterase response to monocrotophos and abate. Bull Environ Contam Toxicol. 1992 Jun;48(6):850-6. |
6(0,0,1,1) | Details |
| 15041023 | Li F, Han Z: Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis gossypii Glover. Insect Biochem Mol Biol. 2004 Apr;34(4):397-405. |
6(0,0,0,6) | Details |
| 15364600 | Rao JV, Kavitha P: Toxicity of azodrin on the morphology and acetylcholinesterase activity of the earthworm Eisenia foetida. Environ Res. 2004 Nov;96(3):323-7. The acute toxicity of azodrin (monocrotophos, an organophosphorus insecticide) was determined on a soil organism, Eisenia foetida. |
5(0,0,0,5) | Details |
| 16563591 | Caldas ED, Boon PE, Tressou J: Probabilistic assessment of the cumulative acute exposure to organophosphorus and insecticides in the Brazilian diet. Toxicology. 2006 May 1;222(1-2):132-42. Epub 2006 Mar 6. In the present study, the cumulative exposure of 25 acetylcholinesterase (AChE) inhibiting pesticides through the consumption of nine fruits and vegetables by the Brazilian population was assessed. Monocrotophos and triazophos, in addition to aldicarb, had the highest calculated RPF in any scenario. |
4(0,0,0,4) | Details |
| 18371707 | Du D, Chen S, Cai J, Zhang A: Electrochemical pesticide sensitivity test using acetylcholinesterase biosensor based on colloidal gold nanoparticle modified sol-gel interface. Talanta. 2008 Jan 15;74(4):766-72. Epub 2007 Jul 24. Typical pesticides such as monocrotophos, methyl parathion and carbaryl were selected for pesticide sensitivity tests. |
3(0,0,0,3) | Details |
| 17328951 | Dutta K, Bhattacharyay D, Mukherjee A, Setford SJ, Turner AP, Sarkar P: Detection of pesticide by polymeric enzyme electrodes. Ecotoxicol Environ Saf. 2008 Mar;69(3):556-61. Epub 2007 Feb 27. Screen-printed electrodes (SPEs) containing immobilized acetylcholine esterase (AChE) enzyme were used for the electrochemical determination of organophosphorous (OP) and pesticides. Responses were observed for the pesticides Monocrotophos, Malathion, Metasystox and Lannate over the concentration range 0-10 ppb (microg L (-1)). |
3(0,0,0,3) | Details |
| 9339739 | Rahman MF, Siddiqui MK, Mustafa M: Effects of a new phosphorothionate (RPR-V) on ATPases and acetylcholinesterase in rat brain by subchronic dosing. J Appl Toxicol. 1997 Sep-Oct;17(5):273-8. |
3(0,0,0,3) | Details |
| 15679473 | Antonijevic B, Bokonjic D, Stojiljkovic MP, Kilibarda V, Milovanovic ZA, Nedeljkovic M, Maksimovic M: Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. Basic Clin Pharmacol Toxicol. 2005 Feb;96(2):111-7. Activities of brain, diaphragmal and erythrocyte acetylcholinesterase, as well as of plasma carboxylesterases were determined at different time intervals (10, 40 and 60 min.) after administration of the antidotes. |
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