| Name | phospholipase C |
|---|---|
| Synonyms | PLC L; PLCE; PLC L (PLC epsilon); PLCL; PLCL 1; PLCL1; PLDL 1; PLDL1… |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11564657 | Berg KA, Cropper JD, Niswender CM, Sanders-Bush E, Emeson RB, Clarke WP: RNA-editing of the 5-HT (2C) receptor alters agonist-receptor-effector coupling specificity. Br J Pharmacol. 2001 Sep;134(2):386-92. The (2C) (5-HT (2C)) receptor couples to both phospholipase C (PLC)- (IP) and phospholipase A (2) (PLA (2))- (AA) signalling cascades. |
1(0,0,0,1) | Details |
| 20007479 | Li YC, Xi D, Roman J, Huang YQ, Gao WJ: Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J Neurosci. 2009 Dec 9;29(49):15551-63. Here, we show the signaling pathways involved in hyperdopaminergic regulation of NMDA receptor functions in the prefrontal cortex by incubating cortical slices with high concentration of or administering reuptake inhibitor 1-(2-[bis-(4-fluorophenyl) methoxy] ethyl)- 4-(3-phenylpropyl) piperazine (GBR12909) in vivo. |
0(0,0,0,0) | Details |
| 12167288 | Vidulescu C, Mironneau J, Mironneau C, Popescu LM: Messenger molecules of the phospholipase signaling system have dual effects on vascular smooth muscle contraction. J Cell Mol Med. 2000 Jul-Sep;4(3):196-206. However, when added during -induced plateau, phospholipase D shortly potentiated it. b) The protein kinase C activator, phorbol dibutyrate potentiated both the exogenous phospholipase C-induced contraction and the -induced plateau, while the protein kinase C inhibitor 1-(-5-isoquinolinesulfonyl)-2-methyl-piperazine relaxed the plateau. c) When added before indomethacin inhibited both phasic and tonic contractions, but when added during the tonic contraction shortly potentiated it. |
32(0,1,1,2) | Details |
| 12837534 | Fringuelli R, Schiaffella F, Utrilla Navarro MP, Milanese L, Santini C, Rapucci M, Marchetti C, Riccardi C: 1,4-benzothiazine analogues and apoptosis: structure-activity relationship. Bioorg Med Chem. 2003 Jul 31;11(15):3245-54. Apoptosis is mediated through a complex of biochemical events including specific-phospholipase C (PC-PLC) activation, acidic sphingomyelinase (aSMase) activation and generation, caspase-8 and caspase-3 activation. In particular, we synthesised analogues that differed in the nature of skeleton (1,4-benzothiazine, 1,4-benzoxazine and 1,2,3,4-tetrahydroquinoline) and in the nature of side chain benzimidazole or piperazine as azole substituent; presence, absence or transformation of alcoholic group). |
1(0,0,0,1) | Details |
| 11259531 | McKune CM, Watts SW: Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J Pharmacol Exp Ther. 2001 Apr;297(1):88-95. We hypothesized that a 5-HT2A receptor, as in the rat, mediates contraction by activating L-type channels, phospholipase C (PLC), and kinase (s). Our hypothesis was further supported by the finding that antagonists with affinity for the 5-HT2A receptor, ketanserin, 1-(1-naphthyl) piperazine, spiperone, and LY53857, reduced -induced contraction. |
1(0,0,0,1) | Details |