| Name | acetolactate synthase |
|---|---|
| Synonyms | Acetolactate synthase; OR10B1P |
| Name | sulfometuron |
|---|---|
| CAS | 2-[[[[(4,6-dimethyl-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16159170 | Ambrona J, Maqueda M, Zamora E, Ramirez M: Sulfometuron resistance as a genetic marker for yeast populations in wine fermentations. J Agric Food Chem. 2005 Sep 21;53(19):7438-43. The mutations were dominant and were located at the ilv2 locus that encodes for acetolactate synthase enzyme. |
1(0,0,0,1) | Details |
| 17315272 | Kuk YI, Bugos NR: Cross-resistance profile of mesosulfuron-methyl-resistant Italian ryegrass in the southern United States. Pest Manag Sci. 2007 Apr;63(4):349-57. This study was conducted to determine the resistance pattern of diclofop-resistant ryegrass accessions from the southern United States to mesosulfuron-methyl, a recently commercialized herbicide for ryegrass control in wheat; to determine the cross-resistance pattern of a Lolium multiflorum Lam. (Italian ryegrass) accession, 03-1, to acetolactate synthase (ALS) and carboxylase (ACCase) inhibitors; and to determine the resistance mechanism of Italian ryegrass to mesosulfuron-methyl. One accession, 03-1, was resistant to mesosulfuron-methyl as well as to other ALS inhibitor herbicides such as chlorsulfuron, imazamox and sulfometuron. |
1(0,0,0,1) | Details |
| 3881312 | Falco SC, Dumas KS: Genetic analysis of mutants of Saccharomyces cerevisiae resistant to the herbicide sulfometuron methyl. Genetics. 1985 Jan;109(1):21-35. Several lines of evidence demonstrate that the SMR1 mutations (47 dominant and four semidominant) are alleles of ILV2 which encodes acetolactate synthase (ALS), the target of SM. |
1(0,0,0,1) | Details |
| 16665827 | Hartnett ME, Newcomb JR, Hodson RC: Mutations in Chlamydomonas reinhardtii Conferring Resistance to the Herbicide Sulfometuron Methyl. Plant Physiol. 1987 Dec;85(4):898-901. All possess a form of acetolactate synthase (ALS) whose specific activity in cell extracts is 100- to 1000-fold more resistant to SM than is the specific activity of wild-type enzyme. |
1(0,0,0,1) | Details |
| 2699328 | LaRossa RA, Van Dyk TK: Leaky and mutations of Salmonella typhimurium conferring suphometuron methyl sensitivity. J Gen Microbiol. 1989 Aug;135(8):2209-22. The herbicide suphometuron methyl inhibits the utilization of and by the branched-chain amino acid biosynthetic enzyme acetolactate synthase. |
1(0,0,0,1) | Details |
| 2989783 | Falco SC, Dumas KS, Livak KJ: Nucleotide sequence of the yeast ILV2 gene which encodes acetolactate synthase. Nucleic Acids Res. 1985 Jun 11;13(11):4011-27. ALS has recently been shown to be the target in bacteria, yeast and plants, of the potent new herbicide sulfometuron methyl. |
1(0,0,0,1) | Details |
| 14729707 | Schmitz G, Downs DM: Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of deaminase (IlvA) in Salmonella enterica serovar Typhimurium. J Bacteriol. 2004 Feb;186(3):803-10. Strains lacking yjgF showed an increased sensitivity to sulfometruron methyl, a potent inhibitor of acetolactate synthase. |
1(0,0,0,1) | Details |
| 3003025 | Van Dyk TK, LaRossa RA: Sensitivity of a Salmonella typhimurium aspC mutant to sulfometuron methyl, a potent inhibitor of acetolactate synthase II. J Bacteriol. 1986 Feb;165(2):386-92. |
162(2,2,2,2) | Details |
| 16593715 | Yadav N, McDevitt RE, Benard S, Falco SC: Single amino acid substitutions in the enzyme acetolactate synthase confer resistance to the herbicide sulfometuron methyl. 69: id: 7581216 Error occurred: Error 11 (Resource temporarily unavailable)Proc Natl Acad Sci U S A. 1986 Jun;83(12):4418-4422. Sulfometuron methyl, a sulfonylurea herbicide, blocks growth of bacteria, yeast, and higher plants by inhibition of acetolactate synthase (EC 4.1.3.18), the first common enzyme in the biosynthesis of branched-chain amino acids. |
250(3,3,4,5) | Details |
| 3039301 | Van Dyk TK, LaRossa RA: Involvement of ack-pta operon products in metabolism by Salmonella typhimurium. Mol Gen Genet. 1987 May;207(2-3):435-40. The herbicide sulfometuron methyl inhibits acetolactate synthase II of Salmonella typhimurium, resulting in toxic accumulation of |
82(1,1,1,2) | Details |
| 9473030 | Van Dyk TK, Ayers BL, Morgan RW, Larossa RA: Constricted flux through the branched-chain amino acid biosynthetic enzyme acetolactate synthase triggers elevated expression of genes regulated by rpoS and internal acidification. J Bacteriol. 1998 Feb;180(4):785-92. The first common enzyme of and biosynthesis, acetolactate synthase (ALS), is specifically inhibited by the herbicide sulfometuron methyl (SM). |
82(1,1,1,2) | Details |
| 15133116 | Kingsbury JM, Yang Z, Ganous TM, Cox GM, McCusker JH: Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo. Microbiology. 2004 May;150(Pt 5):1547-58. C. neoformans is highly resistant to the commercially available acetolactate synthase inhibitor, sulfometuron methyl (SM). |
33(0,1,1,3) | Details |
| 16653216 | Christopher JT, Powles SB, Holtum JA: Resistance to Acetolactate Synthase-Inhibiting Herbicides in Annual Ryegrass (Lolium rigidum) Involves at Least Two Mechanisms. 47: id: 10561230 Error occurred: Error 11 (Resource temporarily unavailable)Plant Physiol. 1992 Dec;100(4):1909-1913. The concentrations of herbicide required to reduce in vitro acetolactate synthase (ALs) activity 50% with respect to control assays minus herbicide for biotype WLR1 was greater than those for susceptible biotype VLR1 by a factor of > 30, > 30, 7,4, and 2 for the herbicides chlorsulfuron, sulfometuron-methyl, imazapyr, imazathapyr, and imazamethabenz, respectively. |
32(0,1,1,2) | Details |
| 3071726 | LaRossa RA, Van Dyk TK: Utilization of sulfometuron methyl, an acetolactate synthase inhibitor, in molecular biological and metabolic studies of plants and microbes. Methods Enzymol. 1988;166:97-107. |
31(0,1,1,1) | Details |
| 3061621 | Maiti SN, Zink MW, Rank GH: Effect of and the herbicide sulfometuron methyl on acetolactate synthase activity in nuclear and plasmid-borne sulphometuron methyl resistant Saccharomyces cerevisiae strains. Can J Microbiol. 1988 May;34(5):680-5. |
12(0,0,2,2) | Details |
| 12060231 | Kovar JL, Zhang J, Funke RP, Weeks DP: Molecular analysis of the acetolactate synthase gene of Chlamydomonas reinhardtii and development of a genetically engineered gene as a dominant selectable marker for genetic transformation. Plant J. 2002 Jan;29(1):109-17. Genomic and cDNA clones of the acetolactate synthase (ALS) gene of Chlamydomonas reinhardtii have been isolated from a mutant, c85-20 (Hartnett et al., 1987), that is resistant to high concentrations of sulfometuron methyl (SMM) and related sulfonylurea herbicides. |
7(0,0,1,2) | Details |
| 15992616 | Fernandez-Gonzalez M, Ubeda JF, Cordero-Otero RR, Thanvanthri Gururajan V, Briones AI: Engineering of an oenological Saccharomyces cerevisiae strain with pectinolytic activity and its effect on wine. Int J Food Microbiol. 2005 Jul 15;102(2):173-83. Yeast transformation was carried out by an integrative process targeting a dispensable upstream region of the acetolactate synthase locus (ILV2), which determines sulfometuron methyl resistance. |
6(0,0,1,1) | Details |
| 3006586 | Van Dyk TK, Falco SC, LaRossa RA: Rapid physical mapping by transposon Tn5 mutagenesis to localize the cloned yeast ILV2 gene. Appl Environ Microbiol. 1986 Jan;51(1):206-8. A rapid method for Tn5 mutagenesis of cloned genes on multicopy plasmids was used to map a yeast ILV2 mutant allele encoding a sulfometuron methyl-resistant acetolactate synthase. |
6(0,0,1,1) | Details |
| 16666001 | Saxena PK, King J: Herbicide Resistance in Datura innoxia: Cross-Resistance of Sulfonylurea-Resistant Cell Lines to Imidazolinones. Plant Physiol. 1988 Mar;86(3):863-867. Cells resistant to the sulfonylurea herbicides chlorsulfuron and sulfometuron methyl were isolated from a predominantly haploid cell suspension culture of Datura innoxia P. Both classes of herbicides tested inhibited acetolactate synthase activity isolated from wild type cells. |
3(0,0,0,3) | Details |
| 11813100 | Preston C, Powles SB: Evolution of herbicide resistance in weeds: initial frequency of target site-based resistance to acetolactate synthase-inhibiting herbicides in Lolium rigidum. Heredity. 2002 Jan;88(1):8-13. The frequency of individuals resistant to the sulfonylurea herbicide sulfometuron-methyl varied from 2.2 x 10 (-5) to 1.2 x 10 (-4) and the frequency of individuals resistant to the imidazolinone herbicide imazapyr varied from 1 x 10 (-5) to 5.8 x 10 (-5) depending on the population. |
2(0,0,0,2) | Details |
| 3031008 | LaRossa RA, Van Dyk TK, Smulski DR: Toxic accumulation of caused by inhibition of the branched-chain amino acid biosynthetic enzyme acetolactate synthase in Salmonella typhimurium. J Bacteriol. 1987 Apr;169(4):1372-8. Growth inhibition of wild-type bacteria by the herbicide sulfometuron methyl was prevented by supplementing the medium with an allosteric inhibitor of deaminase-catalyzed synthesis of |
2(0,0,0,2) | Details |
| 2820932 | Van Dyk TK, Smulski DR, Chang YY: Pleiotropic effects of poxA regulatory mutations of Escherichia coli and Salmonella typhimurium, mutations conferring sulfometuron methyl and hypersensitivity. J Bacteriol. 1987 Oct;169(10):4540-6. In addition, the following phenotypes were identified for the E. coli and S. typhimurium poxA mutants: hypersensitivity to SM and (AKB), deficiency in AKB metabolism, reduced activity of acetolactate synthase, and hypersensitivity to a wide range of bacterial growth inhibitors, including antibiotics, amino acid analogs, and dyes. |
1(0,0,0,1) | Details |
| 11015603 | Jia MH, Larossa RA, Lee JM, Rafalski A, Derose E, Gonye G, Xue Z: Global expression profiling of yeast treated with an inhibitor of amino acid biosynthesis, sulfometuron methyl. Physiol Genomics. 2000 Aug 9;3(2):83-92. SM, a potent herbicide, inhibits acetolactate synthase, a branched-chain amino acid biosynthetic enzyme. |
1(0,0,0,1) | Details |
| 3069583 | Xiao W, Rank GH: The yeast ILV2 gene is under general amino acid control. Genome. 1988 Dec;30(6):984-6. The yeast ILV2 gene encodes acetolactate synthase, the first enzyme in the biosynthesis of and Genetic evidence for general amino acid control was the gcn4 suppression of high level resistance to sulfometuron methyl by the SMRI-410 allele of ILV2. |
1(0,0,0,1) | Details |
| 2455608 | Xiao W, Rank GH: Generation of an ilv bradytrophic phenocopy in yeast by antisense RNA. Curr Genet. 1988 Apr;13(4):283-9. Chimaeric genes were constructed containing the 5' upstream and partial coding sequence of SMR1--a sulfometuron methyl resistant allele of the ILV2 locus. Antisense RNA inhibited synthesis of the SMR1 gene product acetolactate synthase and thus repressed cellular growth which resulted in a bradytrophic auxotroph revertable by addition of and |
1(0,0,0,1) | Details |
| 17665369 | Yu Q, Nelson JK, Zheng MQ, Jackson M, Powles SB: Molecular characterisation of resistance to ALS-inhibiting herbicides in Hordeum leporinum biotypes. Pest Manag Sci. 2007 Sep;63(9):918-27. BACKGROUND: The acetolactate synthase (ALS)-inhibiting herbicide sulfosulfuron is registered in Australia for the selective control of Hordeum leporinum Link. in wheat crops. RESULTS: Dose-response studies revealed very high level (> 340-fold) resistance to the sulfonylurea herbicides sulfosulfuron and sulfometuron. |
1(0,0,0,1) | Details |