| Name | butyrylcholinesterase |
|---|---|
| Synonyms | Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase… |
| Name | naled |
|---|---|
| CAS | 1,2-dibromo-2,2-dichloroethyl dimethyl phosphate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 4139990 | Coppage DL, Matthews E: Short-term effects of organophosphate pesticides on cholinesterases of estuarine fishes and pink shrimp. Bull Environ Contam Toxicol. 1974 May;11(5):483-8. |
1(0,0,0,1) | Details |
| 15888665 | Quistad GB, Klintenberg R, Casida JE: Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants. Toxicol Sci. 2005 Aug;86(2):291-9. Epub 2005 May 11. The most potent in vitro inhibitors for human erythrocyte and mouse brain APH are DFP (IC (50) 11-17 nM), chlorpyrifos oxon (IC (50) 21-71 nM), dichlorvos (IC (50) 230-560 nM), naled (IC (50) 370-870 nM), and their analogs with modified alkyl substituents. (3) H-diisopropyl fluorophosphate is a potent inhibitor of mouse blood and brain APH in vivo (ED (50) 0.09-0.2 mg/kg and 0.02-0.03 mg/l for ip and vapor exposure, respectively). Mouse blood and brain APH and blood butyrylcholinesterase (BChE) are of similar sensitivity to DFP in vitro and in vivo (ip and vapor exposure), but APH inhibition is much more persistent in vivo (still > 80% inhibition after 4 days). |
1(0,0,0,1) | Details |
| 1711162 | Soininen H, Unni L, Shillcutt S: Effect of acute and chronic cholinesterase inhibition on biogenic amines in rat brain. Neurochem Res. 1990 Dec;15(12):1185-90. Despite high brain ChE inhibition induced by metrifonate (MTF), dichlorvos (DDVP) or naled no changes in brain (NA), (DA) or occurred due to treatment with the study drugs in the acute study. |
2(0,0,0,2) | Details |