| Name | SP B |
|---|---|
| Synonyms | 18 kDa pulmonary surfactant protein; 6 kDa protein; PSP B; Pulmonary surfactant apoprotein PSP B; Pulmonary surfactant associated proteolipid SPL(Phe); Pulmonary surfactant associated protein B; Pulmonary surfactant associated protein B precursor; SFTB 3… |
| Name | nitrofen |
|---|---|
| CAS | 2,4-dichloro-1-(4-nitrophenoxy)benzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16490937 | Gonzalez-Reyes S, Martinez L, Martinez-Calonge W, Fernandez-Dumont V, Tovar JA: Effects of nitrofen and vitamins A, C and E on maturation of cultured human H441 pneumocytes. Biol Neonate. 2006;90(1):9-16. Epub 2006 Feb 20. RESULTS: Nitrofen severely decreased TTF-1, HNF-3beta and SP-B mRNA expression by H441 pneumocytes in culture. |
16(0,0,2,6) | Details |
| 17245593 | Takayasu H, Nakazawa N, Montedonico S, Sugimoto K, Sato H, Puri P: Impaired alveolar epithelial cell differentiation in the hypoplastic lung in nitrofen-induced congenital diaphragmatic hernia. Pediatr Surg Int. 2007 May;23(5):405-10. To test the hypothesis that the differentiation of AECs-II to AECs-I is impaired in the CDH hypoplastic lung, we investigated molecular markers for AECs-I [ICAM-1, T1alpha, aquaporin 5 (AQP5)] and molecular markers for AECs-II [thyroid transcription factor-1 (Ttf-1), surfactant protein (SP)-B and C] in the nitrofen-induced CDH lung. |
13(0,0,2,3) | Details |
| 16863852 | Gonzalez-Reyes S, Martinez L, Martinez-Calonge W, Fernandez-Dumont V, Tovar JA: Effects of antioxidant vitamins on molecular regulators involved in lung hypoplasia induced by nitrofen. J Pediatr Surg. 2006 Aug;41(8):1446-52. Thyroid transcription factor 1 (TTF-1), hepatocyte nuclear factor 3beta (HNF-3beta), and surfactant protein B (SP-B) proteins were measured by immunoblot assay in lung homogenates from rat fetuses exposed in utero to either nitrofen 100 mg intragastrically or vehicle. |
13(0,0,2,3) | Details |
| 11051153 | Guarino N, Oue T, Shima H, Puri P: Antenatal dexamethasone enhances surfactant protein synthesis in the hypoplastic lung of nitrofen-induced diaphragmatic hernia in rats. J Pediatr Surg. 2000 Oct;35(10):1468-73. The aim of this study was to investigate whether maternal administration of dexamethasone has any effect on the expression of surfactant protein A and surfactant protein B in nitrofen-induced experimental CDH rat model. |
10(0,0,1,5) | Details |
| 12194114 | Leinwand MJ, Tefft JD, Zhao J, Coleman C, Anderson KD, Warburton D: Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse. J Pediatr Surg. 2002 Sep;37(9):1263-8. Furthermore, the mRNA expression of proliferative and developmental markers was decreased in nitrofen-exposed E12 lungs cultured for 4 days (as a percentage of age-matched controls): cyclin A (69.28%; P =.04), Nkx2.1 (44.4%, 0.04), SP-A (24.1%; P =.008), SP-B (23.4%; P =.05), SP-C (20%; P =.06), and CC-10 (13.8%; P =.04). |
6(0,0,1,1) | Details |
| 11076806 | Guilbert TW, Gebb SA, Shannon JM: Lung hypoplasia in the nitrofen model of congenital diaphragmatic hernia occurs early in development. Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1159-71. Expression of surfactant protein B and C mRNAs was significantly decreased in the nitrofen litters. |
6(0,0,1,1) | Details |
| 10830305 | Losada A, Tovar JA, Xia HM, Diez-Pardo JA, Santisteban P: Down-regulation of thyroid transcription factor-1 gene expression in fetal lung hypoplasia is restored by glucocorticoids. Endocrinology. 2000 Jun;141(6):2166-73. To gain new insights into the causes of this disorder and the effect of prenatal hormonal treatment on reducing mortality in these infants, we evaluated the expression of TTF-1 as marker of lung morphogenesis and SP-B as marker of lung maturity. |
5(0,0,0,5) | Details |
| 11057544 | Shima H, Guarino N, Puri P: Effect of hyperoxia on surfactant protein gene expression in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats. Pediatr Surg Int. 2000;16(7):473-7. Reverse-transcription polymerase chain reaction (RT-PCR) was performed to evaluate the relative amounts of mRNA expression of SP-A, SP-B, SP-C, and SP-D. |
3(0,0,0,3) | Details |
| 12378441 | Benachi A, Chailley-Heu B, Barlier-Mur AM, Dumez Y, Bourbon J: Expression of surfactant proteins and thyroid transcription factor 1 in an ovine model of congenital diaphragmatic hernia. J Pediatr Surg. 2002 Oct;37(10):1393-8. By contrast with the nitrofen model, TTF-1 expression was not altered in the surgical model indicating different underlying molecular mechanisms in both models. The mRNA levels for SPs and TTF-1 were determined by Northern blot analysis; SP-A and SP-B protein levels were assessed by Western blot analysis. |
3(0,0,0,3) | Details |
| 11588001 | Thebaud B, Barlier-Mur AM, Chailley-Heu B, Henrion-Caude A, Tibboel D, Dinh-Xuan AT, Bourbon JR: Restoring effects of on surfactant synthesis in nitrofen-induced congenital diaphragmatic hernia in rats. Am J Respir Crit Care Med. 2001 Sep 15;164(6):1083-9. The proportion of type II cells assessed by SP-B immunolabeling was lowered in N/+DH and restored by vit A treatment. |
1(0,0,0,1) | Details |
| 12904592 | Van Tuyl M, Blommaart PE, Keijzer R, Wert SE, Ruijter JM, Lamers WH, Tibboel D: Pulmonary surfactant protein A, B, and C mRNA and protein expression in the nitrofen-induced congenital diaphragmatic hernia rat model. Pediatr Res. 2003 Nov;54(5):641-52. Epub 2003 Aug 6. The cellular concentration (mean OD) of SP-A and SP-B mRNA was similar at all stages whereas the mean OD of SP-C mRNA and the volume fraction of cells (% Area) expressing SP mRNA was higher in CDH lungs at term. |
1(0,0,0,1) | Details |
| 12217217 | Mori K, Kurihara N, Obi S, Hayashida S, Tokieda K, Ikeda K: Intratracheal instillation of perfluorocarbon rescued mice with primary pulmonary hypoplasia. Exp Lung Res. 2002 Sep;28(6):523-33. The aim of this study was to investigate the effect of perfluorocarbon on the respiratory status of newborn mice with pulmonary hypoplasia without diaphragmatic defects, following intrauterine exposure to nitrofen. |
0(0,0,0,0) | Details |