Protein Information

Name tumor necrosis factor alpha
Synonyms Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2…

Compound Information

Name nitrofen
CAS 2,4-dichloro-1-(4-nitrophenoxy)benzene

Reference List

PubMed Abstract RScore(About this table)
10541330 Shima H, Ohshiro K, Taira Y, Miyazaki E, Oue T, Puri P: Antenatal dexamethasone suppresses tumor necrosis factor-alpha expression in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats. Pediatr Res. 1999 Nov;46(5):633-7.
32(0,1,1,2) Details
12759764 Unemoto K, Sakai M, Shima H, Guarino N, Puri P: Increased expression of ICAM-1 and VCAM-1 in the lung of nitrofen-induced congenital diaphragmatic hernia in rats. Pediatr Surg Int. 2003 Jul;19(5):365-70. Epub 2003 May 21.

Recently, increased expression of inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been reported in both humans and animal models with CDH and the decreased TNF-alpha expression in CDH lung after antenatal dexamethasone (Dex) treatment.
1(0,0,0,1) Details
15256756 Hong CC, Shimomura-Shimizu M, Muroi M, Tanamoto K: Effect of endocrine disrupting chemicals on lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by mouse macrophages. Biol Pharm Bull. 2004 Jul;27(7):1136-9.

To assess the effect of EDCs on the development of infectious disease, we investigated the effect of eighteen possible EDCs on mouse macrophage production of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) in response to bacterial endotoxin in vitro and ex vivo.
Of chemicals we examined, simazine, nitrofen, and benzyl butyl phthalate inhibited lipopolysaccharide (LPS)-induced TNF-alpha production by mouse macrophage cell line RAW 264 in vitro.
1(0,0,0,1) Details