Protein Information

Name ET A
Synonyms EDNRA; ET A; ETA; ETA R; ETRA; Endothelin A receptor; Endothelin 1 receptor; Endothelin 1 receptor precursor…

Compound Information

Name nitrofen
CAS 2,4-dichloro-1-(4-nitrophenoxy)benzene

Reference List

PubMed Abstract RScore(About this table)
12407540 Guarino N, Puri P: Antenatal dexamethasone enhances endothelin-1 synthesis and gene expression in the heart in congenital diaphragmatic hernia in rats. J Pediatr Surg. 2002 Nov;37(11):1563-7.

The aim of this study was to determine cardiac gene expression of ET-1 and of its receptor ET (A) and the cardiac ET-1 content in the heart of nitrofen-induced CDH in rats and to evaluate the effect of antenatal Dexamethasone (Dex) treatment.
33(0,1,1,3) Details
19851775 Dingemann J, Doi T, Ruttenstock E, Puri P: Upregulation of endothelin receptors A and B in the nitrofen induced hypoplastic lung occurs early in gestation. Pediatr Surg Int. 2010 Jan;26(1):65-9.

We hypothesized that pulmonary expression of EDNRA and EDNRB is up-regulated at early gestational stages in the nitrofen model.
21(0,0,3,6) Details
10693666 Shima H, Oue T, Taira Y, Miyazaki E, Puri P: Antenatal dexamethasone enhances endothelin receptorB expression in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats. J Pediatr Surg. 2000 Feb;35(2):203-7.

Two different receptors (ET (A) and ET (B)) for ET-1 have been characterized.
3(0,0,0,3) Details
9473106 Okazaki T, Sharma HS, McCune SK, Tibboel D: Pulmonary vascular balance in congenital diaphragmatic hernia: enhanced endothelin-1 gene expression as a possible cause of pulmonary vasoconstriction. J Pediatr Surg. 1998 Jan;33(1):81-4.

ET-1 exerts its role in controlling vascular tone through two different subtype receptors, endothelin-A receptor (ETA) which is responsible for vasoconstriction and endothelin-B receptor (ETB) which is responsible for vasodilatation by induction of nitric oxide synthase.
CDH was induced in rats by administration of 100 mg of nitrofen dissolved in olive oil on day 10 of gestation.
1(0,0,0,1) Details
9695743 Coppola CP, Au-Fliegner M, Gosche JR: Endothelin-1 pulmonary vasoconstriction in rats with diaphragmatic hernia. . J Surg Res. 1998 Apr;76(1):74-8.

ET-A receptors are increased in the nitrofen model of CDH in rats.
81(1,1,1,1) Details