Protein Information

Name proliferating cell nuclear antigen
Synonyms Cyclin; DNA polymerase delta auxillary protein; PCNA; Proliferating cell nuclear antigen; DNA polymerase delta auxillary proteins; Proliferating cell nuclear antigens

Compound Information

Name nitrofen
CAS 2,4-dichloro-1-(4-nitrophenoxy)benzene

Reference List

PubMed Abstract RScore(About this table)
17439724 Tong QS, Zheng LD, Tang ST, Jiang GS, Ruan QL, Zeng FQ, Dong JH: Nitrofen suppresses cell proliferation and promotes mitochondria-mediated apoptosis in type II pneumocytes. Acta Pharmacol Sin. 2007 May;28(5):672-84.

RESULTS: Nitrofen inhibited the cell proliferation of A549 cells in a dose- and time-dependent manner, accompanied by downregulation of PCNA.
163(2,2,2,3) Details
19009301 Mayer S, Klaritsch P, Sbragia L, Toelen J, Till H, Deprest JA: Maternal administration of betamethasone inhibits proliferation induced by fetal tracheal occlusion in the nitrofen rat model for congenital diaphragmatic hernia: a placebo-controlled study. Pediatr Surg Int. 2008 Dec;24(12):1287-95.

Necropsy was done on ED21.5 to obtain lung-to-body-weight ratio (LBWR), and perform quantitative RT-PCR and fluorescent immunostaining for Ki-67 and proliferating cell nuclear antigen (PCNA) in fetal lungs.
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15083329 Gonzalez-Reyes S, Martinez L, Tovar JA: Vitamin C rescues in part the effects of nitrofen on cultured human pneumocytes. Pediatr Surg Int. 2004 Apr;20(4):258-62. Epub 2004 Apr 9.

The culture dishes were recovered at 72 h for immunohistochemical (PCNA for proliferation, bis-benzimide for apoptosis, anti-SpB and anti-TTF-1 antibodies for SpB and TTF-1 assessment) and molecular studies.
1(0,0,0,1) Details
16490937 Gonzalez-Reyes S, Martinez L, Martinez-Calonge W, Fernandez-Dumont V, Tovar JA: Effects of nitrofen and vitamins A, C and E on maturation of cultured human H441 pneumocytes. Biol Neonate. 2006;90(1):9-16. Epub 2006 Feb 20.

The cells were also immunohistochemically stained for assessment of proliferation (PCNA) and apoptosis (bis-benzimide) status and SP-B and TTF-1 protein expressions.
1(0,0,0,1) Details