| Name | MAPK (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | nitrofen |
|---|---|
| CAS | 2,4-dichloro-1-(4-nitrophenoxy)benzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17439724 | Tong QS, Zheng LD, Tang ST, Jiang GS, Ruan QL, Zeng FQ, Dong JH: Nitrofen suppresses cell proliferation and promotes mitochondria-mediated apoptosis in type II pneumocytes. Acta Pharmacol Sin. 2007 May;28(5):672-84. Meanwhile, nitrofen strongly activated the p38 mitogen-activated protein kinase (p38-MAPK). |
193(2,3,3,3) | Details |
| 16988192 | Nogueira-Silva C, Santos M, Baptista MJ, Moura RS, Correia-Pinto J: IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching. Pediatr Res. 2006 Nov;60(5):530-6. Epub 2006 Sep 20. Normal and nitrofen-induced hypoplastic lung explants were cultured with increasing IL-6 doses or IL-6 neutralizing antibodies. Branching, cellular proliferation (Ki-67) and MAPK phosphorylation in fetal lung explants were analyzed. |
3(0,0,0,3) | Details |
| 11584394 | Kling DE, Narra V, Islam S, Kinane TB, Alessandrini A, Ercolani L, Donahoe PK, Schnitzer JJ: Decreased mitogen activated protein kinase activities in congenital diaphragmatic hernia-associated pulmonary hypoplasia. J Pediatr Surg. 2001 Oct;36(10):1490-6. METHODS: ERK-1 activities were measured using immune-complex kinase assays on fetal whole-lung lysates obtained from both nitrofen and olive oil-treated (control) pregnant rats. |
2(0,0,0,2) | Details |
| 12060561 | Chinoy MR, Graybill MM, Miller SA, Lang CM, Kauffman GL: Angiopoietin-1 and VEGF in vascular development and angiogenesis in hypoplastic lungs. Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L60-6. We hypothesized that exposure of murine fetuses to environmental toxins, such as nitrofen, during early embryogenesis alters vasculogenesis. We assessed exogenous VEGF-mediated endothelial cell response on extracellular signal-regulated kinase (ERK) 1/2, also referred to as p44/42 mitogen-activated protein kinase. |
1(0,0,0,1) | Details |