Protein Information

Name epidermal growth factor
Synonyms EGF; Epidermal growth factor; Pro epidermal growth factor; Pro epidermal growth factor precursor; URG; Urogastrone; epidermal growth factor (beta urogastrone); Epidermal growth factors…

Compound Information

Name nitrofen
CAS 2,4-dichloro-1-(4-nitrophenoxy)benzene

Reference List

PubMed Abstract RScore(About this table)
17191579 Wang Y, Liu W, Lin H: [Effect and significance of tetrandrine on epidermal growth factor and its receptor in the lung of congenital diaphragmatic hernia rat model]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006 Nov;20(11):1109-13.

OBJECTIVE: To investigate the effect of the traditional Chinese medicine "Tetrandrine"(TET) and its significance on epidermal growth factor (EGF) and its receptor (EGFR) in the lung of nitrofen-induced congenital diaphragmatic hernia (CDH) rat model.
82(1,1,1,2) Details
14694368 Li J, Hu T, Liu W, Xiang B, Jiang X: Effect of epidermal growth factor on pulmonary hypoplasia in experimental diaphragmatic hernia. J Pediatr Surg. 2004 Jan;39(1):37-42.

The aim of this study was to investigate a new and much less invasive therapeutic strategy, namely the maternal intraperitoneal administration of epidermal growth factor (EGF) and its effect on pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia (CDH) rat model, especially its effect on type II pneumocytes.
7(0,0,1,2) Details
11409163 Teramoto H, Puri P: Gene expression of insulin-like growth factor-1 and epidermal growth factor is downregulated in the heart of rats with nitrofen-induced diaphragmatic hernia. Pediatr Surg Int. 2001 May;17(4):284-7.
7(0,0,1,2) Details
12215028 Jesudason EC: Challenging embryological theories on congenital diaphragmatic hernia: future therapeutic implications for paediatric surgery. Ann R Coll Surg Engl. 2002 Jul;84(4):252-9.

Unlike the surgically-created lamb model, the nitrofen rat model permits investigation of embryonic lung growth in CDH.
Evaluating this hypothesis further, we examined effects of an HS-independent growth factor (epidermal growth factor, EGF) on hypoplastic lung development.
1(0,0,0,1) Details
17923190 Lin H, Wang Y, Xiong Z, Tang Y, Liu W: Effect of antenatal tetrandrine administration on endothelin-1 and epidermal growth factor levels in the lungs of rats with experimental diaphragmatic hernia. J Pediatr Surg. 2007 Oct;42(10):1644-51.

METHODS: A single oral dose (115 mg/kg) of nitrofen on day 9.5 of pregnancy was maternally administered to induce CDH.
1(0,0,0,1) Details
10466594 Zgleszewski SE, Cilley RE, Krummel TM, Chinoy MR: Effects of dexamethasone, growth factors, and tracheal ligation on the development of nitrofen-exposed hypoplastic murine fetal lungs in organ culture. J Pediatr Surg. 1999 Aug;34(8):1187-95.

BACKGROUND/PURPOSE: The addition of growth factors EGF (epidermal growth factor) plus TGFbeta1 (transforming growth factor beta1; E + T) or dexamethasone (DEX) to normal murine fetal lungs in culture enhances lung development.
1(0,0,0,1) Details