Protein Information

Name angiotensin I
Synonyms AGT; ANG II; ANHU; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensinogen precursor; SERPINA 8…

Compound Information

Name nitrofen
CAS 2,4-dichloro-1-(4-nitrophenoxy)benzene

Reference List

PubMed Abstract RScore(About this table)
15578192 Teramoto H, Shinkai M, Puri P: Altered expression of angiotensin II receptor subtypes and transforming growth factor-beta in the heart of nitrofen-induced diaphragmatic hernia in rats. Pediatr Surg Int. 2005 Mar;21(3):148-52. Epub 2004 Dec 2.
82(1,1,1,2) Details
9766355 Au-Fliegner M, Salami S, Gosche JR: Pulmonary arterioles from rats with congenital diaphragmatic hernias are hypoplastic but not hyperresponsive. J Pediatr Surg. 1998 Sep;33(9):1366-70.

The authors compared the responses of isolated third-generation pulmonary arterioles from normal rats and from rats with nitrofen-induced CDH to K+-induced depolarization, phenylephrine, angiotensin II, serotonin, and the thromboxane A2 agonist, U46619.
31(0,1,1,1) Details
18405707 Baptista MJ, Nogueira-Silva C, Areias JC, Correia-Pinto J: Perinatal profile of ventricular overload markers in congenital diaphragmatic hernia. J Pediatr Surg. 2008 Apr;43(4):627-33.

During gestation, the expression of BNP and angiotensinogen mRNA underwent significant oscillation compared with control in both nitrofen-exposed fetuses, although we cannot identify significant differences between the nitrofen and CDH groups.
15(0,0,2,5) Details
7729378 Bos AP, Sluiter W, Tenbrinck R, Kraak-Slee R, Tibboel D: Angiotensin-converting enzyme activity is increased in lungs of rats with pulmonary hypoplasia and congenital diaphragmatic hernia. Exp Lung Res. 1995 Jan-Feb;21(1):41-50.

ACE converts angiotensin I to the vasoconstrictor angiotensin II, and it inactivates the vasodilator bradykinin.
CDH was induced in fetal rats by oral administration of 115 mg/kg Nitrofen to the mother on day 10.5 of pregnancy.
1(0,0,0,1) Details
16292651 Chertin B, Nakazawa N, Montedonico S, Shima H, Puri P: Altered renin-angiotensin system gene expression causes renal hypoplasia in the rats with nitrofen-induced diaphragmatic hernia. Pediatr Surg Int. 2006 Jan;22(1):57-60.

Reverse transcription polymerase chain reaction was performed to evaluate the relative amount of angiotensinogen (AGT), angiotensin II type 1 receptor with 1a and 1b subtypes (AT (1a) R and AT (1b) R), angiotensin II type 2 receptor (AT (2) R), angiotensin-converting enzyme (ACE) and renin expression in the kidney.
1(0,0,0,1) Details