Protein Information

Name protoporphyrinogen oxidase
Synonyms Mutant protoporphyrinogen oxidase; VP; PPO; PPOX; Protoporphyrinogen oxidase; V290M; Protoporphyrinogen oxidases

Compound Information

Name nitrofen
CAS 2,4-dichloro-1-(4-nitrophenoxy)benzene

Reference List

PubMed Abstract RScore(About this table)
1404247 Jacobs JM, Sinclair PR, Gorman N, Jacobs NJ, Sinclair JF, Bement WJ, Walton H: Effects of diphenyl ether herbicides on porphyrin accumulation by cultured hepatocytes. J Biochem Toxicol. 1992 Summer;7(2):87-95.

In vitro enzyme studies of hepatic mitochondria isolated from rat and chick embryos demonstrated that protoporphyrinogen oxidase, the penultimate enzyme of heme biosynthesis, was inhibited by low concentrations of acifluorfen, nitrofen, or acifluorfen methyl with the latter being the most potent inhibitor.
82(1,1,1,2) Details