Protein Information

Name tropoelastin
Synonyms ELN; WS; WBS; Elastin; Elastin precursor; SVAS; Tropoelastin; Elastins…

Compound Information

Name nitrofen
CAS 2,4-dichloro-1-(4-nitrophenoxy)benzene

Reference List

PubMed Abstract RScore(About this table)
12194112 Guarino N, Teramoto H, Shima H, Oue T, Puri P: Effect of mechanical ventilation on the pulmonary expression and production of elastin in nitrofen-induced diaphragmatic hernia in rats. J Pediatr Surg. 2002 Sep;37(9):1253-7.
88(1,1,1,8) Details
17303798 Boucherat O, Benachi A, Barlier-Mur AM, Franco-Montoya ML, Martinovic J, Thebaud B, Chailley-Heu B, Bourbon JR: Decreased lung fibroblast growth factor 18 and elastin in human congenital diaphragmatic hernia and animal models. Am J Respir Crit Care Med. 2007 May 15;175(10):1066-77. Epub 2007 Feb 15.

OBJECTIVES: To document FGF18 and elastin in human CDH and ovine surgical and rat nitrofen models and to use models to evaluate the benefit of treatments.
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10359170 Taira Y, Oue T, Shima H, Miyazaki E, Puri P: Increased tropoelastin and procollagen expression in the lung of nitrofen-induced diaphragmatic hernia in rats. J Pediatr Surg. 1999 May;34(5):715-9.
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15136996 Mychaliska GB, Officer SM, Heintz CK, Starcher BC, Pierce RA: Pulmonary elastin expression is decreased in the nitrofen-induced rat model of congenital diaphragmatic hernia. J Pediatr Surg. 2004 May;39(5):666-71.
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11329586 Guarino N, Shima H, Puri P: Structural immaturity of the heart in congenital diaphragmatic hernia in rats. J Pediatr Surg. 2001 May;36(5):770-3.

Reverse transcription polymerase chain reaction (RT-PCR) was performed to evaluate the relative amount of tropoelastin and alpha1 (I) procollagen mRNA expression.
METHODS: CDH model was induced in pregnant rats after administration of 100 mg of nitrofen on day 9.5 of gestation (term, 22 days).
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20035915 Klaritsch P, Mayer S, Sbragia L, Toelen J, Roubliova X, Lewi P, Deprest JA: Albumin as an adjunct to tracheal occlusion in fetal rats with congenital diaphragmatic hernia: a placebo-controlled study. Am J Obstet Gynecol. 2010 Feb;202(2):198.e1-9. Epub 2009 Dec 24.

OBJECTIVE: We sought to investigate effects of intratracheal albumin injection prior to tracheal occlusion (TO) on lung proliferation in fetal rats with nitrofen-induced congenital diaphragmatic hernia.
Secondary outcomes were lung-to-bodyweight ratio (LBWR), tropoelastin expression, density and spatial distribution of elastin, pulmonary/alveolar morphometry, and fetal survival.
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11381408 Kanai M, Kitano Y, von Allmen D, Davies P, Adzick NS, Flake AW: Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia: tracheal occlusion reverses the arterial structural abnormality. J Pediatr Surg. 2001 Jun;36(6):839-45.

Coronal sections of the lungs were stained with elastin van Gieson.
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10926554 Chinoy MR, Zgleszewski SE, Cilley RE, Krummel TM: Dexamethasone enhances ras-recision gene expression in cultured murine fetal lungs: role in development. Am J Physiol Lung Cell Mol Physiol. 2000 Aug;279(2):L312-8.


LOX enzyme is known to downregulate p21 (ras) protein and play a central role in the maturation of collagen and elastin in the extracellular matrix as well as modulate the cytoskeletal elements.
1(0,0,0,1) Details