| Name | surfactant protein |
|---|---|
| Synonyms | 35 kDa pulmonary surfactant associated protein; PSAP; Alveolar proteinosis protein; PSP A; PSPA; SFTP 1; SFTP1; SFTPA… |
| Name | nitrofen |
|---|---|
| CAS | 2,4-dichloro-1-(4-nitrophenoxy)benzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11051153 | Guarino N, Oue T, Shima H, Puri P: Antenatal dexamethasone enhances surfactant protein synthesis in the hypoplastic lung of nitrofen-induced diaphragmatic hernia in rats. J Pediatr Surg. 2000 Oct;35(10):1468-73. |
86(1,1,1,6) | Details |
| 11278175 | Utsuki T, Hashizume K, Iwamori M: Impaired spreading of surfactant phospholipids in the lungs of newborn rats with pulmonary hypoplasia as a model of congenital diaphragmatic hernia induced by nitrofen. Biochim Biophys Acta. 2001 Mar 30;1531(1-2):90-8. In nitrofen-treated fetuses, the concentration of disat-PC in the lungs was lower than those in control fetuses, and surfactant apoprotein SP-A was similarly reduced in nitrofen-treated fetuses. |
81(1,1,1,1) | Details |
| 9476886 | Mysore MR, Margraf LR, Jaramillo MA, Breed DR, Chau VL, Arevalo M, Moya FR: Surfactant protein A is decreased in a rat model of congenital diaphragmatic hernia. Am J Respir Crit Care Med. 1998 Feb;157(2):654-7. We hypothesized that the expression of surfactant protein A (SP-A) would be altered in developing lungs from rat fetuses with congenital diaphragmatic hernia (CDH) induced by maternal ingestion of 2,4-dichlorophenyl-p-nitrophenyl ether (Nitrofen) on Day 9 of gestation. |
20(0,0,3,5) | Details |
| 10370019 | Losada A, Xia H, Migliazza L, Diez-Pardo JA, Santisteban P, Tovar JA: Lung hypoplasia caused by nitrofen is mediated by down-regulation of thyroid transcription factor TTF-1. Pediatr Surg Int. 1999;15(3-4):188-91. Thyroid transcription factor 1 (TTF-1) is involved in lung ontogeny and regulation of the expression of surfactant proteins, and is likely abnormally expressed in nitrofen-induced lung hypoplasia. |
12(0,0,2,2) | Details |
| 11057544 | Shima H, Guarino N, Puri P: Effect of hyperoxia on surfactant protein gene expression in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats. Pediatr Surg Int. 2000;16(7):473-7. |
9(0,0,1,4) | Details |
| 12904592 | Van Tuyl M, Blommaart PE, Keijzer R, Wert SE, Ruijter JM, Lamers WH, Tibboel D: Pulmonary surfactant protein A, B, and C mRNA and protein expression in the nitrofen-induced congenital diaphragmatic hernia rat model. Pediatr Res. 2003 Nov;54(5):641-52. Epub 2003 Aug 6. We investigated this hypothesis in the nitrofen-induced CDH rat model and assessed the cellular concentrations of surfactant protein (SP)-A, -B, and -C mRNA with a quantitative radioactive in situ hybridization technique. |
8(0,0,1,3) | Details |
| 9575882 | Coleman C, Zhao J, Gupta M, Buckley S, Tefft JD, Wuenschell CW, Minoo P, Anderson KD, Warburton D: Inhibition of vascular and epithelial differentiation in murine nitrofen-induced diaphragmatic hernia. Am J Physiol. 1998 Apr;274(4 Pt 1):L636-46. We used immunohistochemical localization of alpha-smooth muscle actin (alpha-SMA), platelet endothelial cell adhesion molecule (PECAM)-1, thyroid transcription factor (TTF)-1, surfactant protein (SP) A, SP-C, and competitive RT-PCR quantitation of TTF-1, SP-A, SP-C, and alpha-SMA mRNA expression to characterize the epithelial and vascular phenotype of lungs from ICR fetal mice with a nitrofen-induced DH. |
7(0,0,1,2) | Details |
| 11588001 | Thebaud B, Barlier-Mur AM, Chailley-Heu B, Henrion-Caude A, Tibboel D, Dinh-Xuan AT, Bourbon JR: Restoring effects of on surfactant synthesis in nitrofen-induced congenital diaphragmatic hernia in rats. Am J Respir Crit Care Med. 2001 Sep 15;164(6):1083-9. The expression level of surfactant proteins (SP) -A and -C was decreased in vit A-treated control rats and in nitrofen-exposed fetuses with or without DH. |
7(0,0,1,2) | Details |
| 12378441 | Benachi A, Chailley-Heu B, Barlier-Mur AM, Dumez Y, Bourbon J: Expression of surfactant proteins and thyroid transcription factor 1 in an ovine model of congenital diaphragmatic hernia. J Pediatr Surg. 2002 Oct;37(10):1393-8. By contrast with the nitrofen model, TTF-1 expression was not altered in the surgical model indicating different underlying molecular mechanisms in both models. |
6(0,0,0,6) | Details |
| 17245593 | Takayasu H, Nakazawa N, Montedonico S, Sugimoto K, Sato H, Puri P: Impaired alveolar epithelial cell differentiation in the hypoplastic lung in nitrofen-induced congenital diaphragmatic hernia. Pediatr Surg Int. 2007 May;23(5):405-10. To test the hypothesis that the differentiation of AECs-II to AECs-I is impaired in the CDH hypoplastic lung, we investigated molecular markers for AECs-I [ICAM-1, T1alpha, aquaporin 5 (AQP5)] and molecular markers for AECs-II [thyroid transcription factor-1 (Ttf-1), surfactant protein (SP)-B and C] in the nitrofen-induced CDH lung. |
6(0,0,1,1) | Details |
| 12194114 | Leinwand MJ, Tefft JD, Zhao J, Coleman C, Anderson KD, Warburton D: Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse. J Pediatr Surg. 2002 Sep;37(9):1263-8. Furthermore, the mRNA expression of proliferative and developmental markers was decreased in nitrofen-exposed E12 lungs cultured for 4 days (as a percentage of age-matched controls): cyclin A (69.28%; P =.04), Nkx2.1 (44.4%, 0.04), SP-A (24.1%; P =.008), SP-B (23.4%; P =.05), SP-C (20%; P =.06), and CC-10 (13.8%; P =.04). |
6(0,0,1,1) | Details |
| 11477730 | Chinoy MR, Chi X, Cilley RE: Down-regulation of regulatory proteins for differentiation and proliferation in murine fetal hypoplastic lungs: altered mesenchymal-epithelial interactions. Pediatr Pulmonol. 2001 Aug;32(2):129-41. It is restricted to type II pneumocytes with gestational development in the normal lungs and regulates surfactant proteins. The hypoplastic lungs were created in CD-1 fetal mice by nitrofen exposure (25 mg per pregnant mouse given intragastrically on gestational day 8 [Gd8]), as published earlier. |
4(0,0,0,4) | Details |
| 18435480 | Gallot D, Coste K, Jani J, Roubliova X, Marceau G, Velemir L, Verheyen A, Lemery D, Sapin V, Deprest J: Effects of maternal administration in a congenital diaphragmatic hernia rabbit model. Pediatr Pulmonol. 2008 Jun;43(6):594-603. Maternal retinoid administration has beneficial effects on lung development in the nitrofen rodent toxic model of congenital diaphragmatic hernia (DH). Normal lungs exposed to ATRA had increased surfactant protein mRNA levels without change in type II pneumocyte density. |
3(0,0,0,3) | Details |
| 10830305 | Losada A, Tovar JA, Xia HM, Diez-Pardo JA, Santisteban P: Down-regulation of thyroid transcription factor-1 gene expression in fetal lung hypoplasia is restored by glucocorticoids. Endocrinology. 2000 Jun;141(6):2166-73. It is involved in the transcription of surfactant proteins (SP), which are critical in respiratory function. |
1(0,0,0,1) | Details |
| 15707848 | Oshiro T, Asato Y, Sakanashi M, Ohta T, Sugahara K: Differential effects of on fetal lung growth and diaphragmatic formation in nitrofen-induced rat model. Pulm Pharmacol Ther. 2005;18(3):155-64. Epub 2004 Dec 28. The mRNA levels of lung surfactant proteins were decreased in the NIP/ group. |
1(0,0,0,1) | Details |
| 7882903 | Brandsma AE, ten Have-Opbroek AA, Vulto IM, Molenaar JC, Tibboel D: Alveolar epithelial composition and architecture of the late fetal pulmonary acinus: an immunocytochemical and morphometric study in a rat model of pulmonary hypoplasia and congenital diaphragmatic hernia. Exp Lung Res. 1994 Nov-Dec;20(6):491-515. For this purpose, a rat model of pulmonary hypoplasia in association with congenital diaphragmatic hernia (CDH) induced by Nitrofen (100 mg on day 10 of pregnancy) was studied. To identify developing alveolar epithelial cells, sections were incubated with anti-surfactant protein A (SP-A; rabbit anti-mouse) or preimmunization serum (indirect immunofluorescence). |
1(0,0,0,1) | Details |
| 16490937 | Gonzalez-Reyes S, Martinez L, Martinez-Calonge W, Fernandez-Dumont V, Tovar JA: Effects of nitrofen and vitamins A, C and E on maturation of cultured human H441 pneumocytes. Biol Neonate. 2006;90(1):9-16. Epub 2006 Feb 20. Several phenotypic features of the alveolar epithelium including surfactant proteins A and B synthesis and its regulation by transcription factors are reproduced in cultured human H441 pneumocytes. |
1(0,0,0,1) | Details |
| 12194113 | Hosgor M, Ijzendoorn Y, Mooi WJ, Tibboel D, De Krijger RR: Thyroid transcription factor-1 expression during normal human lung development and in patients with congenital diaphragmatic hernia. J Pediatr Surg. 2002 Sep;37(9):1258-62. TTF-1 is involved in both lung morphogenesis and in the regulation of surfactant proteins. Recently, low expression of TTF-1 in the nitrofen rat model of congenital diaphragmatic hernia (CDH) was shown and restoration of this downregulation by antenatal glucocorticolds (CS) was reported. |
1(0,0,0,1) | Details |
| 8286785 | Brandsma AE, Tibboel D, Vulto IM, Egberts J, Ten Have-Opbroek AA: Ultrastructural features of alveolar epithelial cells in the late fetal pulmonary acinus: a comparison between normal and hypoplastic lungs using a rat model of pulmonary hypoplasia and congenital diaphragmatic hernia. Microsc Res Tech. 1993 Dec 1;26(5):389-99. Pulmonary hypoplasia in association with congenital diaphragmatic hernia was induced in fetuses by administration of 2,4-dichlorophenyl-p-nitrophenylether (Nitrofen) to pregnant Sprague Dawley rats (100 mg on day 10 of gestation). |
0(0,0,0,0) | Details |