Protein Information

Name vascular endothelial growth factor
Synonyms VEGF; VEGF A; VEGFA; VPF; Vascular endothelial growth factor A; Vascular endothelial growth factor A precursor; Vascular permeability factor; vascular endothelial growth factor…

Compound Information

Name nitrofen
CAS 2,4-dichloro-1-(4-nitrophenoxy)benzene

Reference List

PubMed Abstract RScore(About this table)
16567193 Shinkai M, Shinkai T, Montedonico S, Puri P: Effect of VEGF on the branching morphogenesis of normal and nitrofen-induced hypoplastic fetal rat lung explants. J Pediatr Surg. 2006 Apr;41(4):781-6.

We hypothesized that VEGF may accelerate branching morphogenesis and thus may modulate lung growth in normal and nitrofen-induced pulmonary hypoplastic lungs.
97(1,1,3,7) Details
17993583 Muehlethaler V, Kunig AM, Seedorf G, Balasubramaniam V, Abman SH: Impaired VEGF and nitric oxide signaling after nitrofen exposure in rat fetal lung explants. Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L110-20. Epub 2007 Nov 9.

Disruption of lung architecture after VEGF receptor blockade was similar to nitrofen-induced changes but was more responsive to NO.
93(1,1,3,3) Details
15185205 Chang R, Andreoli S, Ng YS, Truong T, Smith SR, Wilson J, D'Amore PA: VEGF expression is downregulated in nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg. 2004 Jun;39(6):825-8; discussion 825-8.

CONCLUSIONS: Nitrofen downregulates the production of VEGF during gestation and attenuates the peak seen at the onset of the canalicular stage, despite preservation of type-II pneumocytes.
91(1,1,2,6) Details
12021965 Oue T, Yoneda A, Shima H, Taira Y, Puri P: Increased vascular endothelial growth factor peptide and gene expression in hypoplastic lung in nitrofen induced congenital diaphragmatic hernia in rats. Pediatr Surg Int. 2002 May;18(4):221-6.
12(0,0,1,7) Details
9094000 Okazaki T, Sharma HS, Aikawa M, Yamataka A, Nagai R, Miyano T, Tibboel D: Pulmonary expression of vascular endothelial growth factor and myosin isoforms in rats with congenital diaphragmatic hernia. J Pediatr Surg. 1997 Mar;32(3):391-4.

The lungs of nitrofen-induced CDH rat fetuses (n = 16, gestational age 16, 18, 20, and 22 days) were stained immunohistochemically using antibodies against VEGF, SMemb and SM2, while alpha-actin was used as a general marker of vascular smooth muscle cells.
9(0,0,1,4) Details
12060561 Chinoy MR, Graybill MM, Miller SA, Lang CM, Kauffman GL: Angiopoietin-1 and VEGF in vascular development and angiogenesis in hypoplastic lungs. Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L60-6.

We hypothesized that exposure of murine fetuses to environmental toxins, such as nitrofen, during early embryogenesis alters vasculogenesis.
4(0,0,0,4) Details
11076806 Guilbert TW, Gebb SA, Shannon JM: Lung hypoplasia in the nitrofen model of congenital diaphragmatic hernia occurs early in development. Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1159-71.

0(0,0,0,0) Details