Protein Information

Name muscles
Synonyms COX 7a M; COX VIIa M; COX7A; COX7A1; COX7A1 protein; COX7AH; COX7AM; Cytochrome c oxidase subunit 7a H…

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
9688966 Ward CW, Spangenburg EE, Diss LM, Williams JH: Effects of varied fatigue protocols on sarcoplasmic reticulum calcium uptake and release rates. Am J Physiol. 1998 Jul;275(1 Pt 2):R99-R104.


The purpose of this investigation was to examine changes in sarcoplasmic reticulum (SR) function in muscles subjected to different patterns of muscle activity.
3(0,0,0,3) Details
9655756 Ingalls CP, Warren GL, Williams JH, Ward CW, Armstrong RB: E-C coupling failure in mouse EDL muscle after in vivo eccentric contractions. J Appl Physiol. 1998 Jul;85(1):58-67.


The objectives of this research were to determine the contribution of excitation-contraction (E-C) coupling failure to the decrement in maximal isometric tetanic force (Po) in mouse extensor digitorum longus (EDL) muscles after eccentric contractions and to elucidate possible mechanisms.
3(0,0,0,3) Details
16397059 Yamada T, Mishima T, Sakamoto M, Sugiyama M, Matsunaga S, Wada M: Oxidation of myosin heavy chain and reduction in force production in hyperthyroid rat soleus. J Appl Physiol. 2006 May;100(5):1520-6. Epub 2006 Jan 5.


The content of carbonyl groups in myofibrillar protein extracts was elevated (P < 0.05) by approximately 50% in T3-treated muscles.
2(0,0,0,2) Details
9688740 Williams JH, Ward CW, Spangenburg EE, Nelson RM: Functional aspects of skeletal muscle contractile apparatus and sarcoplasmic reticulum after fatigue. J Appl Physiol. 1998 Aug;85(2):619-26.


Frog semitendinosus muscles were stimulated to fatigue, and skinned fibers or a homogenate fraction was prepared from both fatigued and rested contralateral muscles.
2(0,0,0,2) Details
10945837 Choisy S, Huchet-Cadiou C, Leoty C: Differential effects of 4-chloro-m-cresol and caffeine on skinned fibers from rat fast and slow skeletal muscles. J Pharmacol Exp Ther. 2000 Sep;294(3):884-93.


Contractile responses to 4-chloro-m-cresol (4-CmC) were tested in saponin- and Triton X-100-skinned fibers from soleus and edl (extensor digitorum longus) muscles of adult rats and compared with those to caffeine.
2(0,0,0,2) Details
9212139 Gilly H, Musat I, Fricker R, Bittner RE, Steinbereithner K, Kress HG: Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol. Anesth Analg. 1997 Jul;85(1):149-54.


MHEh muscles revealed a dose-response curve similar to that found in MHN specimens.
1(0,0,0,1) Details
11347998 Russell SM: Evaluation of an optical microbiological method for rapidly estimating populations of aerobic bacteria, coliforms, and Escherichia coli from ground pork. J Food Prot. 2001 May;64(5):669-73.

Ground pork samples were analyzed immediately, after temperature abuse at 25 degrees C for various periods of time, or after temperature abuse and dilution by mixing with pork that was prepared by grinding whole muscles that had the outer portion excised using a sterile scalpel.
Each sample was tested using the BioSys for total viable counts (TVC) by placing 2 ml of ground pork homogenate (25 g into 225 ml of sterile 1% buffered peptone water) into 8 ml of nutrient medium containing brom-cresol purple in a test vial and monitoring at 35 degrees C.
1(0,0,0,1) Details
8053891 Treves S, Larini F, Menegazzi P, Steinberg TH, Koval M, Vilsen B, Andersen JP, Zorzato F: Alteration of intracellular Ca2+ transients in COS-7 cells transfected with the cDNA encoding skeletal-muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia. Biochem J. 1994 Aug 1;301 ( Pt 3):661-5.


In the present report we show that the presence of the Arg-to-Cys point mutation in the recombinant RYR expressed in COS-7 transfected cells causes abnormal cytosolic Ca2+ transients in response to 4-chloro-m-cresol, an agent capable of eliciting in vitro contracture of MH-susceptible muscles.
1(0,0,0,1) Details
10714851 Anetseder M, Ritter L, Horbaschek H, Hartung E, Roewer N: The impact of 4-chloro-m-cresol in heparin formulas on malignant hyperthermia: in vitro and in vivo. Acta Anaesthesiol Scand. 2000 Mar;44(3):338-42.


RESULTS: (a) For Liquemin and 4CmC, significant contractures were measured with MHS muscles compared to MHN muscles at 61.4 microM 4CmC. (b) In control sera, the detection threshold for 4CmC was 4 microM.
1(0,0,0,1) Details
8605229 Herrmann-Frank A, Richter M, Sarkozi S, Mohr U, Lehmann-Horn F: 4-Chloro-m-cresol, a potent and specific activator of the skeletal muscle ryanodine receptor. Biochim Biophys Acta. 1996 Feb 9;1289(1):31-40.


In heavy SR vesicles obtained from rabbit back muscles, 4-CmC stimulated (Ca2+)-activated [3H] ryanodine binding with an EC50 of about 100 microM.
1(0,0,0,1) Details
17131831 Katina IE, Nasledov GA: [Effects of agonists and antagonists of rhyanodine receptors on potassium contractures in twitch and tonic frog skeletal muscle fibers]. Biofizika. 2006 Sep-Oct;51(5):898-905.


Dandrolene does not practically affect the contractile responses of tonic fibres, and the concentration of cresol eliciting the contracture for tonic fibres is substantially higher (1 mM) than for twitch fibers (0.25 mM).
0(0,0,0,0) Details