Protein Information

Name lactoperoxidase
Synonyms Airway lactoperoxidase; LPO; Lactoperoxidase; Lactoperoxidase precursor; SAPX; SPO; Salivary peroxidase; Lactoperoxidases…

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
7492606 Sato K, Hasumi H, Tsukidate A, Sakurada J, Nakamura S, Hosoya T: Effects of mixed solvents on three elementary steps in the reactions of horseradish peroxidase and lactoperoxidase. Biochim Biophys Acta. 1995 Nov 15;1253(1):94-102.

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2546939 Nakamura M, Yamazaki I, Kotani T, Ohtaki S: Thyroglobulin-mediated one- and two-electron oxidations of glutathione and ascorbate in thyroid peroxidase systems. J Biol Chem. 1989 Aug 5;264(22):12909-13.


The reactions were analyzed and mimicked with the use of p-cresol and p-acetaminophenol as a mediator in the reactions of lactoperoxidase and thyroid peroxidase.
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8132563 Hori H, Fenna RE, Kimura S, Ikeda-Saito M: Aromatic substrate molecules bind at the distal heme pocket of myeloperoxidase. J Biol Chem. 1994 Mar 18;269(11):8388-92.


The EPR results on lactoperoxidase and intestinal peroxidase also suggest the presence of an aromatic substrate binding site similar to that of myeloperoxidase.
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2730881 Hosoya T, Sakurada J, Kurokawa C, Toyoda R, Nakamura S: Interaction of aromatic donor molecules with lactoperoxidase probed by optical difference spectra. Biochemistry. 1989 Mar 21;28(6):2639-44.

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