Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name diazinon
CAS

Reference List

PubMed Abstract RScore(About this table)
19440498 Slotkin TA, Seidler FJ: Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells. Environ Health Perspect. 2009 Apr;117(4):587-96. Epub 2008 Dec 5.

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20196151 Oruc E: Effects of diazinon on antioxidant defense system and lipid peroxidation in the liver of Cyprinus carpio (L.). Environ Toxicol. 2010 Mar 1.

The results revealed that the antioxidant enzyme activities such as superoxide dismutase, glutathione peroxidase, and catalase were induced by diazinon exposure.
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17722735 Sutcu R, Altuntas I, Buyukvanli B, Akturka O, Ozturka O, Koylu H, Delibas N: The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat erythrocytes: role of vitamins E and C. Toxicol Ind Health. 2007 Feb;23(1):13-7.

Therefore, in this study, we aimed to investigate the effects of acute exposure to organophosphate insecticide diazinon (DI) and possible ameliorating role of vitamins E and C, with the following parameters: lipid peroxidation (LPO) and the activity of the glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in rat erythrocytes.
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15027810 Altuntas I, Kilinc I, Orhan H, Demirel R, Koylu H, Delibas N: The effects of diazinon on lipid peroxidation and antioxidant enzymes in erythrocytes in vitro. Hum Exp Toxicol. 2004 Jan;23(1):9-13.

In experiment 1, the effects of various concentrations of diazinon on LPO and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in erythrocytes were studied.
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18565581 Sarabia L, Maurer I, Bustos-Obregon E: Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on the mouse testis. Ecotoxicol Environ Saf. 2009 Mar;72(3):938-42. Epub 2008 Jun 18.

Morphometrical analysis showed a decrease in seminiferous epithelium height (days 1 and 32), whereas an increase in testicular superoxide dismutase (SOD) activity was detected (day 32).
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15339126 Amer M, Metwalli M, Abu el-Magd Y: Skin diseases and enzymatic antioxidant activity among workers exposed to pesticides. East Mediterr Health J. 2002 Mar-May;8(2-3):363-73.


Activity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase and glutathione reductase was also evaluated.
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16964585 Akturk O, Demirin H, Sutcu R, Yilmaz N, Koylu H, Altuntas I: The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat heart and ameliorating role of vitamin E and vitamin C. Cell Biol Toxicol. 2006 Nov;22(6):455-61. Epub 2006 Sep 11.

For this purpose, experiments were done to study the effects of DI on LPO and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in adult rat heart.
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