diazinon

Identification (Source:EPA,EU)

ID 214
Name diazinon
CAS 333-41-5
IUPAC
Inchi InChI=1S/C12H21N2O3PS/c1-6-15-18(19,16-7-2)17-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3
CIPAC 15
EPA Code 057801
Formula C12H21N2O3PS
SMILES S=P(OCC)(OCC)Oc1nc(nc(c1)C)C(C)C
Status Not Approved

Classification

Mode of Action Non-systemic with respiratory, contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
Pesticide Type Insecticide, Acaricide, Repellent, Veterinary treatment
Chemical Group Organophosphate
Classification Bird repellents
pyrimidine organothiophosphate insecticides
organothiophosphate insecticides
heterocyclic organothiophosphate insecticides
organothiophosphate acaricides

Properties (Source:PubChem)

Molecular Weight 304.35
Physical State Colourless to dark brown liquid
AlogP 3.136
H-Bond Donor 0
H-Bond Acceptor 6
Surface Area 311.25
Polar Surface Area 95.37

Structure



ChemMapper Search Option (Docunmentation of ChemMapper)

3D similarity method

2D similarity method

Compound Database



Bioactivity Database

KEGG (5,928)

PDB (7,072)


Similarity Threshold

Ecotoxicology (Source:PPDB,IPM)

Species Method Study Time Dose Type Value
Algae Acute 72 hour EC50, growth 6.4 mg l-1
Algae Chronic 96 hour NOEC, growth > 10 mg l-1
Aquatic crustaceans Acute 96 hour LC50 0.0042 mg l-1
Aquatic invertebrates Acute 48 hour EC50 0.001 mg l-1
Aquatic invertebrates Chronic 21 day NOEC 0.00056 mg l-1
Birds Acute LD50 1.44 mg kg-1
Birds Short term dietary LC50/LD50 8 mg/kg bw/day
Earthworms Acute 14 day LD50 65 mg kg-1
Fish Chronic 21 day NOEC 0.7 mg l-1
Fish Acute 96 hour LC50 3.1 mg l-1
Honeybees Acute 48 hour LD50 0.09 μg bee-1
Mammals Acute oral LD50 1139 mg kg-1
Mammals Short term dietary NOEL 5 mg kg-1
Mammals Short term dietary NOEL 35 ppm diet
Sediment dwelling organisms Acute 96 hour LC50 0.023 mg l-1
Bio-concentration factor BCF 500
Bio-concentration factor CT50 2 days

Related targets

Target Name RScore (About this table)
cholinesterase 3524(26,58,98,284) Details
Acetylcholinesterase 2652(21,39,76,247) Details
cytochrome P450 (protein family or complex) 515(4,9,11,35) Details
CYP2C19 313(3,5,6,8) Details
kynurenine formamidase 249(3,3,3,9) Details
PON1 355(2,4,10,105) Details
cytochrome P450 1A2 203(2,3,3,13) Details
adenylyl cyclase 165(2,2,2,5) Details
5HT transporter 164(2,2,2,4) Details
CYP3A4 153(1,3,4,8) Details
P glycoprotein 130(1,2,5,5) Details
TEPP 112(1,2,2,2) Details
glial cell line derived neurotrophic factor 112(1,2,2,2) Details
glycogen phosphorylase 101(1,1,4,6) Details
albumin 100(1,1,2,15) Details
C18 96(1,1,1,16) Details
choline acetyltransferase 89(1,1,2,4) Details
protein kinase C (protein family or complex) 87(1,1,2,2) Details
CYP2B6 83(1,1,1,3) Details
ATPase 82(1,1,1,2) Details
CYP2E1 81(1,1,1,1) Details
brain 2 81(1,1,1,1) Details
neurotoxic esterase 81(1,1,1,1) Details
S mephenytoin 4 hydroxylase 93(0,3,3,3) Details
neurotrophic factors 76(0,2,3,11) Details
brains 66(0,2,2,6) Details
tryptophan hydroxylase 63(0,2,2,3) Details
glutathione S transferase 87(0,1,8,22) Details
CYP2D6 45(0,1,3,5) Details
alanine aminotransferase 41(0,1,2,6) Details
muscles 39(0,1,2,4) Details
Fatty acid amide hydrolase 39(0,1,1,9) Details
calcium channel (protein family or complex) 37(0,1,2,2) Details
CS2 33(0,1,1,3) Details
G proteins 33(0,1,1,3) Details
growth associated protein 43 32(0,1,1,2) Details
MS2 31(0,1,1,1) Details
ribosomal protein S5 31(0,1,1,1) Details
BP75 31(0,1,1,1) Details
CYP1A1 31(0,1,1,1) Details
catalase 33(0,0,5,8) Details
superoxide dismutase 21(0,0,3,6) Details
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