| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | diazinon |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16101034 | Bustos-Obregon E, Gonzalez JR, Espinoza O: as protective agent for the cytotoxic effects of diazinon in the spermatogenesis in the earthworm Eisenia foetida. Ital J Anat Embryol. 2005;110(2 Suppl 1):159-65. It inhibits acetylcholinesterase activity and damages reproduction as well as other organic functions mostly by increasing lipid peroxidation. |
1(0,0,0,1) | Details |
| 18394709 | Timchalk C, Poet TS: Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat. Neurotoxicology. 2008 May;29(3):428-43. Epub 2008 Mar 10. It is anticipated that these OPs could interact at a number of important metabolic steps including: CYP450 mediated activation/detoxification, B-esterases [carboxylesterase (CaE), butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE)] or PON-1 (A-esterase) oxon detoxification. |
1(0,0,0,1) | Details |
| 3624768 | Matin MA, Husain K: Changes in cerebral glycogenolysis and related enzymes in diazinon treated hyperglycaemic animals. J Appl Toxicol. 1987 Apr;7(2):131-4. The cerebral acetylcholinesterase activity was significantly reduced. |
1(0,0,0,1) | Details |
| 16455590 | Ozcan Oruc E, Uner N, Sevgiler Y, Usta D, Durmaz H: Sublethal effects of organophosphate diazinon on the brain of Cyprinus carpio. Drug Chem Toxicol. 2006 Jan;29(1):57-67. This study showed that prolonged exposures of C. carpio to diazinon had significant effects on brain acetylcholinesterase activity and that environmentally relevant concentrations of diazinon can significantly inhibit brain acetylcholinesterase activity. |
118(1,2,3,3) | Details |
| 2023308 | Prijono WB, Leighton FA: Parallel measurement of brain acetylcholinesterase and the muscarinic cholinergic receptor in the diagnosis of acute, lethal poisoning by anti-cholinesterase pesticides. J Wildl Dis. 1991 Jan;27(1):110-5. The activity of acetylcholinesterase (AChE) and the density of muscarinic cholinergic binding receptors (mCBR) were measured in brains from normal Japanese quail (Coturnix coturnix japonica) and from quail after lethal intoxication with diazinon. |
115(1,2,2,5) | Details |
| 10771584 | Nigg HN, Knaak JB: Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure. Rev Environ Contam Toxicol. 2000;163:29-111. In some cases, P-450 isozymes catalyze the oxidative cleavage of P-O-aryl bonds (e.g., parathion, methyl parathion, fenitrothion, and diazinon) to form inactive water-soluble alkyl phosphates and aryl leaving groups that are readily conjugated with glucuronic or sulfuric acids and excreted. The basic biochemical characteristics of RBC AChE and BChE were determined in the 1940s. |
6(0,0,0,6) | Details |
| 18674623 | Giron-Perez MI, Zaitseva G, Casas-Solis J, Santerre A: Effects of diazinon and diazoxon on the lymphoproliferation rate of splenocytes from Nile tilapia (Oreochromis niloticus): the immunosuppresive effect could involve an increase in levels. Fish Shellfish Immunol. 2008 Nov;25(5):517-21. Epub 2008 Jul 12. Conversely, ex vivo assays showed that spleen from fish exposed to diazinon presented a lower acetylcholinesterase activity and a higher concentration than non-exposed controls. |
6(0,0,1,1) | Details |
| 18096363 | Timofeeva OA, Roegge CS, Seidler FJ, Slotkin TA, Levin ED: Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicol Teratol. 2008 Jan-Feb;30(1):38-45. Epub 2007 Oct 24. The addition of some inhibition of AChE with a higher dose reversed the cognitive impairment. |
1(0,0,0,1) | Details |
| 7204881 | Hussain MA, Oloffs PC, Blatherwick FJ, Gaunce AP, MacKenzie CJ: Detection of incipient effects of anticholinesterase insecticides in rats and humans by electromyography and cholinesterase assay. J Environ Sci Health B. 1981;16(1):1-19. Rats, fed low levels of diazinon (0.5 and 5.0 mg/kg) and parathion (0.1, 0.5 and 1.0 mg/kg) daily for 26 weeks, and agricultural workers chronically exposed to anticholinesterase insecticides, were monitored by electromyographic (EMG) and blood cholinesterase determinations. Both erythrocyte acetylcholinesterase (AChE) and plasma cholinesterase (ChE) activities were severely inhibited in the treated groups. |
1(0,0,0,1) | Details |
| 15285140 | Brimer L, Bak H, Henriksen SA: Rapid quantitative assay for acaricidal effects on Sarcoptes scabiei var. suis and Otodectes cynotis. Exp Appl Acarol. 2004;33(1-2):81-91. Parasitol. 51: 123-135, 1993 and 59: 249-255, 1995) developed a migration assay for acaricidal effect of acetylcholinesterase inhibitors and macrocyclic lactones utilising Sarcoptes scabiei var. suis mites. The cholinesterase inhibitor diazinon and the amitraz were used as acaricides. |
1(0,0,0,1) | Details |
| 9863774 | Hamm JT, Wilson BW, Hinton DE: Organophosphate-induced acetylcholinesterase inhibition and embryonic retinal cell necrosis in vivo in the teleost (Oryzias latipes). Neurotoxicology. 1998 Dec;19(6):853-69. Diazinon exposure significantly inhibited AChE activity within whole embryos and in homogenates of retinas from treated animals. |
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| 10896849 | de Blaquiere GE, Waters L, Blain PG, Williams FM: Electrophysiological and biochemical effects of single and multiple doses of the organophosphate diazinon in the mouse. Toxicol Appl Pharmacol. 2000 Jul 15;166(2):81-91. The relationship between dose of diazinon, inhibition of acetylcholinesterase, and effect on neuromuscular transmission has been studied in a mouse model. |
95(1,1,3,5) | Details |
| 17936355 | Massa R, Blevins S, Chao SL: Role of acetylcholinesterase and glutathione S-transferase following exposure to nicosulfuron and diazinon in Helicoverpa zea. Ecotoxicol Environ Saf. 2008 Sep;71(1):230-5. Epub 2007 Oct 23. Diazinon, an organophosphorous insecticide, controls insects by inhibiting acetylcholinesterase in the nervous system. |
87(1,1,2,2) | Details |
| 12706585 | White BJ, Legako JA, Harmon HJ: Extended lifetime of reagentless detector for multiple inhibitors of acetylcholinesterase. Biosens Bioelectron. 2003 May;18(5-6):729-34. This technique yields detection limits at 3:1 S/N of 37 ppt for eserine, 50 ppt for galanthamine, 100 ppt for 250 ppt for tetracaine, 45 ppt for diazinon, and 83 ppb for Triton X-100. |
5(0,0,0,5) | Details |
| 12696436 | Bozsik A, Francis F, Gaspar C, Haubruge E: Effect of some insecticides on acetylcholinesterase from beneficial insects: Coccinella septempunctata, Chrysoperla carnea and Forficula auricularia. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2002;67(3):671-7. The beneficial insects showed the least susceptibility to diazinon and the differences between their measured values were not remarkable. |
4(0,0,0,4) | Details |
| 16257396 | Aluigi MG, Angelini C, Falugi C, Fossa R, Genever P, Gallus L, Layer PG, Prestipino G, Rakonczay Z, Sgro M, Thielecke H, Trombino S: Interaction between organophosphate compounds and cholinergic functions during development. Chem Biol Interact. 2005 Dec 15;157-158:305-16. Epub 2005 Oct 28. The biological function of the ChE enzymes is well known and has been studied since the beginning of the XXth century; in particular, acetylcholinesterase (AChE, E.C. 3.1.1.7) is an enzyme playing a key role in the modulation of neuromuscular impulse transmission. The chosen organophosphates were the ones mainly used in Europe: diazinon, chlorpyriphos, malathion, and phentoate, all of them belonging to the thionophosphate chemical class. |
1(0,0,0,1) | Details |
| 20096330 | Rush T, Liu XQ, Hjelmhaug J, Lobner D: Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture. Neuroscience. 2010 Mar 31;166(3):899-906. Epub 2010 Jan 20. The main action of organophosphorous insecticides is generally believed to be the inhibition of acetylcholinesterase (AChE). |
1(0,0,0,1) | Details |
| 18597346 | Caldwell SR, Raushel FM: Detoxification of organophosphate pesticides using an immobilized phosphotriesterase from Pseudomonas diminuta. Biotechnol Bioeng. 1991 Jan 20;37(2):103-9. The immobilization of phosphotriesterase onto trityl agarose provides an effective method esterase onto trityl agarose provides an effective method for hydrolyzing and thus detoxifyuing organophosphate pesticides and mammalian acetylcholinesterase inhinbitors. Several organophosphate pesticides, methyl parathion, ethyl parathion, diazinon, and coumaphos were also hydrolyzed by the immobilized phosphotriesterase. |
1(0,0,0,1) | Details |
| 14677365 | Stanek K, Gabrijelcic E, Drobne D, Trebse P: Inhibition of acetylcholinesterase activity in the terrestrial isopod Porcellio scaber as a biomarker of organophosphorus compounds in food. Arh Hig Rada Toksikol. 2003 Sep;54(3):183-8. The reduction of AChE activity was observed at the lowest diazinon exposure (5 and 10 micrograms/g dry food). |
84(1,1,1,4) | Details |
| 19337507 | Laetz CA, Baldwin DH, Collier TK, Hebert V, Stark JD, Scholz NL: The synergistic toxicity of pesticide mixtures: implications for risk assessment and the conservation of endangered Pacific salmon. Environ Health Perspect. 2009 Mar;117(3):348-53. Epub 2008 Nov 14. METHODS: We measured brain AChE inhibition in juvenile coho salmon (Oncorhynchus kisutch) exposed to sublethal concentrations of the organophosphates diazinon, malathion, and chlorpyrifos, as well as the carbamates carbaryl and carbofuran. |
83(1,1,1,3) | Details |
| 18484351 | Tarhoni MH, Lister T, Ray DE, Carter WG: Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers. 2008 Jun;13(4):343-63. At pesticide exposures producing approximately 30% inhibition of AChE, rat plasma albumin binding in vitro by azamethiphos (oxon), chlorfenvinphos (oxon), chlorpyrifos-oxon, diazinon-oxon and malaoxon was reduced from controls by 9+/-1%, 67+/-2%, 56+/-2%, 54+/-2% and 8+/-1%, respectively. |
82(1,1,1,2) | Details |
| 16289700 | Abdel-Halim KY, Salama AK, El-Khateeb EN, Bakry NM: Organophosphorus pollutants (OPP) in aquatic environment at Damietta Governorate, Egypt: implications for monitoring and biomarker responses. Chemosphere. 2006 Jun;63(9):1491-8. Epub 2005 Nov 14. The obtained results are in parallel to that found in case of cholinesterase activity where the activity of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) was declined at these seasonal period. Chlorpyrifos, chlorpyrifos-methyl, malathion, diazinon, pirimiphos-methyl and profenofos were detected in most samples. |
3(0,0,0,3) | Details |
| 14679985 | Key PB, Fulton MH, Harman-Fetcho JA, McConnell LL: Acetylcholinesterase activity in grass shrimp and aqueous pesticide levels from South Florida drainage canals. Arch Environ Contam Toxicol. 2003 Oct;45(3):371-7. Three organophosphate insecticides (chlorpyrifos, malathion, diazinon) were detected at three sites in two canals (Military and North). |
3(0,0,0,3) | Details |
| 14680115 | Li AY, Davey RB, Miller RJ, George JE: Resistance to coumaphos and diazinon in Boophilus microplus (Acari: Ixodidae) and evidence for the involvement of an oxidative detoxification mechanism. J Med Entomol. 2003 Jul;40(4):482-90. Resistance to coumaphos in the Mexican strains of B. microplus was likely to be conferred by both a cytP450-mediated detoxification mechanism described here and the mechanism of insensitive acetylcholinesterases reported elsewhere. |
1(0,0,0,1) | Details |
| 7097799 | Skinner CS, Kilgore WW: Acute dermal toxicities of various organophosphate insecticides in mice. J Toxicol Environ Health. 1982 Mar;9(3):491-7. Values were simultaneously generated for the ED50 (milligrams per kilogram) for both cholinesterase and acetylcholinesterase. Lethality was greatest with mevinphos, followed by parathion, methyl parathion, diazinon, and azinphosmethyl. |
1(0,0,0,1) | Details |
| 15736872 | Chon TS, Chung N, Kwak IS, Kim JS, Koh SC, Lee SK, Leem JB, Cha EY: Movement behaviour of Medaka (Oryzias latipes) in response to sublethal treatments of diazinon and cholinesterase activity in semi-natural conditions. Environ Monit Assess. 2005 Feb;101(1-3):1-21. Response behaviour was confirmed with toxicological experiments that show the decrease in the acetylcholine esterase activity in the head and body of specimens. |
1(0,0,0,1) | Details |
| 17018647 | Kousba AA, Poet TS, Timchalk C: Age-related brain cholinesterase inhibition kinetics following in vitro incubation with chlorpyrifos-oxon and diazinon-oxon. Toxicol Sci. 2007 Jan;95(1):147-55. Epub 2006 Oct 3. Chlorpyrifos and diazinon are two commonly used organophosphorus insecticides (OPs), and their primary mechanism of action involves the inhibition of acetylcholinesterase by their metabolites chlorpyrifos-oxon (CPO) and diazinon-oxon (DZO), respectively. |
81(1,1,1,1) | Details |
| 12521673 | Gordon CJ, Mack CM: Influence of gender on thermoregulation and cholinesterase inhibition in the long-evans rat exposed to diazinon. J Toxicol Environ Health A. 2003 Feb 14;66(3):291-304. Diazinon is an organophosphate (OP)-based, anticholinesterase insecticide that irreversibly inhibits acetylcholinesterase activity and produces cholinergic stimulation in central nervous system (CNS) and peripheral tissues. |
81(1,1,1,1) | Details |
| 15470232 | Lein PJ, Fryer AD: Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicol Sci. 2005 Jan;83(1):166-76. Epub 2004 Oct 6. To determine if the effects of chlorpyrifos on airway hyperreactivity can be generalized to other OPs, we tested whether parathion and diazinon also inhibit neuronal M2 receptor function resulting in airway hyperreactivity. |
3(0,0,0,3) | Details |
| 10871426 | Parker ML, Goldstein MI: Differential toxicities of organophosphate and insecticides in the nestling European starling (Sturnus vulgaris). Arch Environ Contam Toxicol. 2000 Aug;39(2):233-42. We quantified B-esterase buffering of organophosphate (diazinon and methyl parathion) and (aldicarb and oxamyl) toxicity in nestling European starlings (Sturnus vulgaris). Theoretically, compounds affected by BChE removal would have a higher affinity for BChE or carboxylesterase (CaE) than acetylcholinesterase (AChE). |
3(0,0,0,3) | Details |
| 11459102 | Pogacnik L, Franko M: Determination of organophosphate and pesticides in spiked samples of tap water and fruit juices by a biosensor with photothermal detection. Biosens Bioelectron. 1999 Jun 30;14(6):569-78. The determination of organophosphate (paraoxon, chlorpyrifos, diazinon) and (carbaryl, carbofuran) pesticides in spiked drinking water and fruit juices was carried out using a photothermal biosensor. The biosensor consists of a cartridge containing immobilised enzyme acetylcholinesterase (AChE) placed in a flow-injection analysis (FIA) manifold and a photothermal detector based on thermal lens spectrometry. |
1(0,0,0,1) | Details |
| 15885262 | Timchalk C, Poet TS, Hinman MN, Busby AL, Kousba AA: Pharmacokinetic and pharmacodynamic interaction for a binary mixture of chlorpyrifos and diazinon in the rat. Toxicol Appl Pharmacol. 2005 May 15;205(1):31-42. The primary effects from OP pesticide exposures result from the inhibition of acetylcholinesterase (AChE). |
1(0,0,0,1) | Details |
| 20020979 | Shadnia S, Dasgar M, Taghikhani S, Mohammadirad A, Khorasani R, Abdollahi M: Protective Effects of and N-Acetyl- on Diazinon-Induced Oxidative Stress and Acetylcholinesterase Inhibition in Rats. Toxicol Mech Methods. 2007;17(2):109-15. |
64(0,2,2,4) | Details |
| 18472339 | Temeyer KB, Li AY, Lohmeyer KH, Chen AC, Olafson PU, Sanson DW, Foil LD: Acetylcholinesterase mutation in diazinon-resistant Haematobia irritans (L.) (Diptera: Muscidae). Vet Parasitol. 2008 Jul 4;154(3-4):300-10. Epub 2008 Apr 4. Sequencing of the amplification products revealed that 8/12 of the diazinon-resistant horn flies contained a point mutation previously associated with resistance to organophosphates in house flies and Drosophila, strongly suggesting that this cDNA encodes the AChE that is the target site for organophosphate (OP) pesticide. |
44(0,1,3,4) | Details |
| 20169407 | Mdegela RH, Mosha RD, Sandvik M, Skaare JU: Assessment of acetylcholinesterase activity in Clarias gariepinus as a biomarker of organophosphate and exposure. Ecotoxicology. 2010 Feb 19. Concentrations of pesticides that inhibited 50% (IC (50)) of AChE activities in brain homogenates following in vitro exposures were 0.003, 0.03, 0.15, 190, 0.2, 0.003 and 0.002 muM for carbaryl, chlorfenvinphos, diazinon, dimethoate, fenitrothion, pirimiphosmethyl and profenofos, respectively. |
40(0,1,1,10) | Details |
| 17454383 | Somerset VS, Klink MJ, Baker PG, Iwuoha EI: Acetylcholinesterase-polyaniline biosensor investigation of organophosphate pesticides in selected organic solvents. J Environ Sci Health B. 2007 Mar-Apr;42(3):297-304. Detection limits in the order of 0.147 ppb for diazinon and 0.172 ppb for fenthion in -saline buffer solution, and 0.180 ppb for diazinon and 0.194 ppb for fenthion in -saline buffer solution has been achieved. |
3(0,0,0,3) | Details |
| 2569343 | Patterson TA, Terry AV Jr, Kosh JW: Prevention of physostigmine-, DFP-, and diazinon-induced acute toxicity by monoethylcholine and N-aminodeanol. Br J Pharmacol. 1989 Jun;97(2):451-60. and the analogues monoethylcholine (MEC) and N-aminodeanol (NAD) were examined for prophylactic activity in acute acetylcholinesterase inhibitor toxicity in mice. |
3(0,0,0,3) | Details |
| 8988804 | Wu HX, Evreux-Gros C, Descotes J: Diazinon toxicokinetics, tissue distribution and anticholinesterase activity in the rat. Biomed Environ Sci. 1996 Dec;9(4):359-69. Both red blood cell (RBC) acetylcholinesterase (AChE) and plasma ChE activities were inhibited rapidly (44% and 17% at 10 min, and 36% and 13% min for i.v. and oral administration, respectively), but inhibition of RBC AChE was greater than that of plasma ChE. |
1(0,0,0,1) | Details |
| 1517504 | Saito K, Motoyama N, Dauterman WC: Effect of synergists on the oral and topical toxicity of azamethiphos to organophosphate-resistant houseflies (Diptera: Muscidae). J Econ Entomol. 1992 Aug;85(4):1041-5. The hydrolytic enzymes are more important, but other factors including reduced cuticular penetration and insensitive acetylcholinesterase may be involved.(ABSTRACT TRUNCATED AT 250 WORDS) In contrast, the Yachiyo strain, which show 1,500-fold resistance to diazinon and which has known multiple mechanisms for organophosphate resistance, showed only 6-fold resistance to azamethiphos by topical application and 4-fold resistance by oral administration. |
1(0,0,0,1) | Details |
| 18826034 | Miller RJ, Li AY, Tijerina M, Davey RB, George JE: Differential response to diazinon and coumaphos in a strain of Boophilus microplus (Acari: Ixodidae) collected in Mexico. J Med Entomol. 2008 Sep;45(5):905-11. However, it was determined that it took six times longer to reach 60% inhibition of AChE in the resistant strain compared with the susceptible strain when exposed to the active form of diazinon, diazoxon. |
34(0,1,1,4) | Details |
| 15683842 | Park KH, Kim YS, Chung EY, Choe SN, Choo JJ: Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Dec;139(4):303-8. While other reversible AChE inhibitors such neostigmine and pyridostigmine also depressed the contractility, organophosphate AChE inhibitors malathion, diazinon, or phenthoate did not. |
34(0,1,1,4) | Details |
| 20338157 | Aluigi MG, Guida C, Falugi C: Apoptosis as a specific biomarker of diazinon toxicity in NTera2-D1 cells. Chem Biol Interact. 2010 Mar 22. Its property to express a whole set of molecules related to the cholinergic neurotransmission system, including active acetylcholinesterase (AChE, EC 3.1.1.7) makes it a good alternative model for testing the effects of compounds, such as organophosphorus (OP) insecticides, whose primary target is the inhibition of AChE activity. |
2(0,0,0,2) | Details |
| 15612566 | Taskin V, Kence M: The genetic basis of malathion resistance in housefly (Musca domestica L.) strains from Turkey. Genetika. 2004 Nov;40(11):1475-82. Organophosphate insecticide (parathion/diazinon) resistance in housefly (Musca domestica L.) is associated with the change in carboxylesterase activity. In addition, we checked the malathion carboxylesterase (MCE), percent remaining activities in acetylcholinesterase (AChE), -S-transferase (GST), and general esterase activities in all 5 strains used in this study. |
2(0,0,0,2) | Details |
| 19161234 | Overmyer JP, Smith PF, Kellock KA, Kwon JW, Armbrust KL: Assessment of the toxicological interaction of with cholinesterase inhibiting insecticides in aquatic insects using the black fly, Simulium vittatum IS-7. Environ Toxicol. 2010 Feb;25(1):28-37. Although SSRIs are known to block reuptake sites on cell membranes, they also have been shown to inhibit acetylcholinesterase (AChE) activity. In this study, the interactive effect of (SSRI) in binary combinations with carbaryl insecticide) and diazinon (organophosphate insecticide) was assessed using a 48-h acute toxicity test with black fly larvae, Simulium vittatum IS-7. |
2(0,0,0,2) | Details |
| 16704049 | Scholz NL, Truelove NK, Labenia JS, Baldwin DH, Collier TK: Dose-additive inhibition of chinook salmon acetylcholinesterase activity by mixtures of organophosphate and insecticides. Environ Toxicol Chem. 2006 May;25(5):1200-7. We extracted AChE from the olfactory nervous system of chinook salmon (Oncorhynchus tshawytscha) and investigated the inhibitory effects of organophosphates (the oxon derivatives of diazinon, chlorpyrifos, and malathion) and carbamates (carbaryl and carbofuran), alone and in two-way combinations. |
34(0,1,1,4) | Details |
| 16207942 | Paraoanu LE, Mocko JB, Becker-Roeck M, Smidek-Huhn J, Layer PG: Exposure to diazinon alters in vitro retinogenesis: retinospheroid morphology, development of chicken retinal cell types, and gene expression. Toxicol Sci. 2006 Jan;89(1):314-24. Epub 2005 Oct 5. Acetylcholinesterase activity in diazinon-treated spheres was reduced when compared with controls. |
32(0,1,1,2) | Details |
| 19948211 | Colovic M, Krstic D, Petrovic S, Leskovac A, Joksic G, Savic J, Franko M, Trebse P, Vasic V: Toxic effects of diazinon and its photodegradation products. . Toxicol Lett. 2010 Mar 1;193(1):9-18. Epub 2009 Dec 3. Dose-dependent AChE and Na (+)/K (+)-ATPase inhibition by diazinon was obtained for all investigated cells. |
32(0,1,1,2) | Details |
| 7313514 | Karlsen RL, Sterri S, Lyngaas S, Fonnum F: Reference values for erythrocyte acetylcholinesterase and plasma cholinesterase activities in children, implications for organophosphate intoxication. Scand J Clin Lab Invest. 1981 May;41(3):301-2. |
2(0,0,0,2) | Details |
| 4023425 | Sugiyama S, Igarashi T, Ueno K, Satoh T, Kitagawa H: Increase in anti-carboxylesterase action of organophosphorothioates by (NAD) in vitro. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):455-8. Experiments using with three organophosphorothioates having ethoxy group except for diazinon exhibited greater NAD-effect than those having methoxy ones such as methylparathion and fenitrothion. In addition, the extent of NAD-effect using acetylcholinesterase (AChE) was lesser than that of CEase, therefore, a higher susceptibility of liver microsomal CEase to organophosphorus insecticides may be explained, at least inpart, by NAD-effect. |
1(0,0,0,1) | Details |
| 12469775 | Pesando D, Huitorel P, Dolcini V, Angelini C, Guidetti P, Falugi C: Biological targets of pesticides analysed by alteration of developmental events in the Mediterranean sea urchin, Paracentrotus lividus. Mar Environ Res. 2003 Feb;55(1):39-57. The biological effects of Basudin (an organophosphate compound containing 20% Diazinon), Diazinon (Dzn, a thionophosphate), Carbaryl and Pirimicarb (carbamates) on the early phases of sea urchin development were thus investigated. From the gastrulation stage onwards, the main effects were exerted on the rate of primary mesenchyme cells migration, larval size, perioral arm length, and acetylcholinesterase activity distribution, thus deregulating the cholinergic system, which modulates cell-to-cell communication mediated by the signal molecule |
1(0,0,0,1) | Details |
| 8735462 | Wu HX, Evreux-Gros C, Descotes J: Influence of cimetidine on the toxicity and toxicokinetics of diazinon in the rat. Hum Exp Toxicol. 1996 May;15(5):391-5. The acute toxicity of diazinon, as well as brain acetylcholinesterase and carboxylesterase inhibition, were potentiated by pretreating rats with cimetidine (80 mg kg-1, i.p.) 1 and 24 h prior to diazinon application (50 mg kg-1, i.p.). 3. |
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| 16215695 | Whitehead A, Anderson SL, Ramirez A, Wilson BW: Cholinesterases in aquatic biomonitoring: assay optimization and species-specific characterization for a California native fish. Ecotoxicology. 2005 Aug;14(6):597-606. Epub 2005 Oct 7. Acetylcholinesterase (AChE) was the predominant ChE present in C. occidentalis brain and muscle, and muscle AChE was most sensitive to diazinon inhibition. |
31(0,1,1,1) | Details |
| 7436591 | Dressel TD, Goodale RL, Borner JW, Etani S: A study of the cholinesterases of the canine pancreatic sphincters and the relationship between reduced butyrylcholinesterase activity and pancreatic ductal hypertension. Ann Surg. 1980 Nov;192(5):614-9. In five control dogs, serial sections of the major and minor spincters were stained for acetylcholinesterase (AChE) and BChE activity. |
2(0,0,0,2) | Details |
| 12109753 | Anderson TD, Lydy MJ: Increased toxicity to invertebrates associated with a mixture of atrazine and organophosphate insecticides. Environ Toxicol Chem. 2002 Jul;21(7):1507-14. This study examined the joint toxicity of atrazine and three organophosphate (OP) insecticides (chlorpyrifos, methyl parathion, and diazinon) exposed to Hyalella azteca and Musca domestica. Acetylcholinesterase (AChE) activity also was examined for the individual OPs with and without atrazine treatment. |
2(0,0,0,2) | Details |
| 1602578 | Kendall RJ, Brewer LW, Hitchcock RR, Mayer JR: American wigeon mortality associated with turf application of diazinon AG500. J Wildl Dis. 1992 Apr;28(2):263-7. The brains of all 85 wigeon were analyzed for acetylcholinesterase (AChE) activity. |
2(0,0,0,2) | Details |
| 11350214 | Quistad GB, Sparks SE, Casida JE: Fatty acid amide hydrolase inhibition by organophosphorus pesticides. Toxicol Appl Pharmacol. 2001 May 15;173(1):48-55. These BDPOs and EOPF inhibit mouse brain FAAH in vitro with > or =200-fold higher potency than for AChE. Five OP pesticides inhibit 50% of the brain FAAH activity (ED50) at <30 mg/kg 4 h after ip administration to mice; while inhibition by chlorpyrifos, diazinon, and methamidophos occurs near acutely toxic levels, profenofos and tribufos are effective at asymptomatic doses. |
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| 16166182 | Muggleton NG, Smith AJ, Scott EA, Wilson SJ, Pearce PC: A long-term study of the effects of diazinon on sleep, the electrocorticogram and cognitive behaviour in common marmosets. J Psychopharmacol. 2005 Sep;19(5):455-66. |
0(0,0,0,0) | Details |
| 18633600 | Sidiropoulou E, Sachana M, Flaskos J, Harris W, Hargreaves AJ, Woldehiwet Z: Diazinon oxon affects the differentiation of mouse N2a neuroblastoma cells. Arch Toxicol. 2009 Apr;83(4):373-80. Epub 2008 Jul 17. |
0(0,0,0,0) | Details |
| 20020955 | Uner N, Sevgiler Y, Durmaz H, Piner P: In vivo Alterations in -Related Processes, Lipid Peroxidation, and Cholinesterase Enzyme Activities in the Liver of Diazinon-Exposed Oreochromis niloticus. Toxicol Mech Methods. 2007;17(6):317-24. |
0(0,0,0,0) | Details |
| 16481026 | Stanek K, Drobne D, Trebse P: Linkage of biomarkers along levels of biological complexity in juvenile and adult diazinon fed terrestrial isopod (Porcellio scaber, Isopoda, Crustacea). Chemosphere. 2006 Sep;64(10):1745-52. Epub 2006 Feb 14. In parallel laboratory experiments, we determined the effect of a typical representative of organophosphorous pesticides, diazinon, on AChE activity, lipid, protein and content, weight change, feeding activity and mortality of juvenile and adult terrestrial isopods Porcellio scaber (Isopoda, Crustacea). |
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| 18565581 | Sarabia L, Maurer I, Bustos-Obregon E: prevents damage elicited by the organophosphorous pesticide diazinon on the mouse testis. Ecotoxicol Environ Saf. 2009 Mar;72(3):938-42. Epub 2008 Jun 18. This study evaluates the effects of a single dose of diazinon and -a powerful antioxidant-on plasmatic acetylcholinesterase activity and testis histopathology in adult mice 1 and 32 days post-treatment. |
19(0,0,3,4) | Details |
| 2809535 | Meneely GA, Wyttenbach CR: Effects of the organophosphate insecticides diazinon and parathion on bobwhite quail embryos: skeletal defects and acetylcholinesterase activity. J Exp Zool. 1989 Oct;252(1):60-70. |
19(0,0,3,4) | Details |
| 985225 | Stone BF, Wilson JT, Youlton NJ: Linkage and dominance characteristics of genes for resistance to organophosphorus acaricides and allelic inheritance of decreased brain cholinesterase activity in three strains of the cattle tick, Boophilus microplus. Aust J Biol Sci. 1976 Jul;29(3):251-63. Resistance to the organophosphorus acaricides diazinon, dimethoate and formothion in the Biarra (B), Mackay (M) and Ridgelands (R) strains respectively of the cattle tick B. microplus has been shown previously to be controlled in each strain by a single incompletely dominant autosomal genetic factor. F1 adult progeny of B x M and R x M crossings exhibited the incompletely recessive mutant-type decreased brain acetylcholinesterase (AChE) activity common to strains B, M and R, thus satisfying the test for allelism. |
2(0,0,0,2) | Details |
| 15474619 | Poet TS, Kousba AA, Dennison SL, Timchalk C: Physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus pesticide diazinon. Neurotoxicology. 2004 Dec;25(6):1013-30. The toxicological effects of DZN are primarily mediated through the effects of its toxic metabolite, DZN-oxon on acetylcholinesterases, which results in accumulation of at neuronal junctions. |
2(0,0,0,2) | Details |
| 18401943 | Zawisza-Raszka A, Dolezych B: Acetylcholinesterase, catalase and glutathione S-transferase activity in beet armyworm (Spodoptera exigua) exposed to and/or diazinon. Acta Biol Hung. 2008 Mar;59(1):31-45. |
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| 17933502 | Yehia MA, El-Banna SG, Okab AB: Diazinon toxicity affects histophysiological and biochemical parameters in rabbits. Exp Toxicol Pathol. 2007 Nov;59(3-4):215-25. Epub 2007 Oct 22. So, the current work aimed to investigate the effects of diazinon exposure on some physiological and biochemical parameters, as well as, histopathological changes and histochemical acetyl-cholinesterase activity (AChE). |
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| 1282384 | Dutta H, Marcelino J, Richmonds C: Brain acetylcholinesterase activity and optomotor behavior in bluegills, Lepomis macrochirus exposed to different concentrations of diazinon. Arch Int Physiol Biochim Biophys. 1992 Sep-Oct;100(5):331-4. Therefore estimation of AChE activity and changes in the optomotor response are taken as criteria to study the effects of different concentrations (15, 30, 45, 60 and 75 micrograms/l) of diazinon, an organophosphorus compound, in bluegill Sunfish, Lepomis macrochirus. |
9(0,0,1,4) | Details |
| 15557345 | Buratti FM, D'Aniello A, Volpe MT, Meneguz A, Testai E: Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms. Drug Metab Dispos. 2005 Mar;33(3):295-302. Epub 2004 Nov 22. These results are in line with those found with chlorpyrifos, diazinon, azynphos-methyl, and parathion, characterized by the presence of an aromatic ring in the molecule. Malathion desulfuration has been characterized in human liver microsomes (HLMs) with a method based on acetylcholinesterase inhibition that is able to detect nanomolar levels of oxon. |
1(0,0,0,1) | Details |
| 15889748 | Li AY, Davey LR, George JE: Carbaryl resistance in Mexican strains of the southern cattle tick (Acari: Ixodidae). J Econ Entomol. 2005 Apr;98(2):552-6. Tick strains from the cattle fever tick quarantine zone in Texas were more susceptible to carbaryl than to coumaphos or diazinon. Resistance to carbaryl was likely conferred by insensitive acetylcholinesterase. |
1(0,0,0,1) | Details |
| 19779279 | Okamura A, Kamijima M, Ohtani K, Yamanoshita O, Nakamura D, Ito Y, Miyata M, Ueyama J, Suzuki T, Imai R, Takagi K, Nakajima T: Broken sperm, cytoplasmic droplets and reduced sperm motility are principal markers of decreased sperm quality due to organophosphorus pesticides in rats. J Occup Health. 2009;51(6):478-87. Epub 2009 Sep 25. METHODS: Ten-week-old Wistar rats were divided into 4 groups (n=10) and orally administered corn oil, dichlorvos (DDVP; 5, 10 mg/kg) or diazinon (DZN; 3 mg/kg) 6 days a week for 9 wk. |
0(0,0,0,0) | Details |
| 12019994 | Weick J, Thorn RS: Effects of acute sublethal exposure to coumaphos or diazinon on acquisition and discrimination of odor stimuli in the honey bee (Hymenoptera: Apidae). J Econ Entomol. 2002 Apr;95(2):227-36. |
0(0,0,0,0) | Details |
| 8658539 | Marinovich M, Ghilardi F, Galli CL: Effect of pesticide mixtures on in vitro nervous cells: comparison with single pesticides. Toxicology. 1996 Apr 30;108(3):201-6. The toxicity of dimethoate, azinphos-methyl, diazinon, pirimiphos methyl, organophosphorus insecticides, and benomyl (a benzimidazole fungicide) singly and in mixture was studied in a human neuroblastoma cell line, SH-SY5Y. |
0(0,0,0,0) | Details |
| 17615116 | Carter WG, Tarhoni M, Rathbone AJ, Ray DE: Differential protein adduction by seven organophosphorus pesticides in both brain and thymus. Hum Exp Toxicol. 2007 Apr;26(4):347-53. We found significant adduction of partially characterized protein targets in both rat brain and thymus by azamethiphos, chlorfenvinphos, chlorpyrifos-oxon, diazinon-oxon, dichlorvos and malaoxon, in vitro and pirimiphos-methyl in vivo. |
0(0,0,0,0) | Details |
| 17239417 | Flaskos J, Harris W, Sachana M, Munoz D, Tack J, Hargreaves AJ: The effects of diazinon and cypermethrin on the differentiation of neuronal and glial cell lines. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):172-80. Epub 2006 Dec 15. |
0(0,0,0,0) | Details |
| 11757741 | Leland JE, Mullins DE, Berry DF: Evaluating environmental hazards of land applying composted diazinon using earthworm bioassays. J Environ Sci Health B. 2001 Nov;36(6):821-34. |
0(0,0,0,0) | Details |
| 9292287 | Worek F, Backer M, Thiermann H, Szinicz L, Mast U, Klimmek R, Eyer P: Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning. Hum Exp Toxicol. 1997 Aug;16(8):466-72. These data may help to define more precisely the indications and limitations of oxime therapy in organophosphate (OP) poisoning. 2 Diethylphosphoryl-AChE resulting from intoxications with parathion, chlorpyrifos, chlorfenvinphos, diazinon and other OPs is characterized by slow spontaneous reactivation and low propensity for ageing. |
9(0,0,1,4) | Details |
| 17126609 | Jemec A, Drobne D, Tisler T, Trebse P, Ros M, Sepcic K: The applicability of acetylcholinesterase and glutathione S-transferase in Daphnia magna toxicity test. Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jan;144(4):303-9. Epub 2006 Oct 19. The relevance of acetylcholinesterase (AChE) and glutathione S-transferase (GST) activity in D. magna exposed to cadmium, and diazinon was evaluated in connection with this standard test. |
9(0,0,1,4) | Details |
| 10509429 | Abdelsalam EB: potential of six organophosphorus compounds in adult hens. Vet Hum Toxicol. 1999 Oct;41(5):290-2. The potential of trichlorfon, diazinon, phosmet, dichlorvos, phosphamidon and coumaphos was evaluated for their ability to inhibit brain neurotoxic esterase (NTE) activity in adult hens. All compounds were administered at high single oral doses and the NTE and acetylcholinesterase (AchE) activities were measured at 24 h and 6 w later. |
1(0,0,0,1) | Details |
| 7242025 | Sovocool GW, Harless RL, Bradway DE, Wright LH, Lores EM, Feige LE: The recognition of diazinon, an organophosphorus pesticide, when found in samples in the form of decomposition products. J Anal Toxicol. 1981 Mar-Apr;5(2):73-80. Also found were several potent acetylcholinesterase inhibitors: monothionotetraethylpyrophosphate; dithionotetraethylpyrophosphate [3689-24-5]; tetraethylpyrophosphate. |
1(0,0,0,1) | Details |
| 11838436 | Lee HS, Kim YA, Cho YA, Lee YT: Oxidation of organophosphorus pesticides for the sensitive detection by a cholinesterase-based biosensor. Chemosphere. 2002 Jan;46(4):571-6. The sensor system consisted of a reactor with acetylcholinesterase (AChE) immobilized on a controlled pore glass and a detector with a tubular H (+)-selective membrane electrode. A calibration curve for diazinon, over the concentration range of 10 (-11)-10 (-4) M, was obtained. |
1(0,0,0,1) | Details |
| 11481665 | Abu-Qare AW, Abou-Donia MB: Inhibition and recovery of maternal and fetal cholinesterase enzyme activity following a single cutaneous dose of methyl parathion and diazinon, alone and in combination, in pregnant rats. J Appl Toxicol. 2001 Jul-Aug;21(4):307-16. Recovery of maternal and fetal brain AChE activity was in the order of diazinon > combination of diazinon and methyl parathion > methyl parathion 96 h after dosing. |
8(0,0,1,3) | Details |
| 19610437 | Zibaee A, Sendi JJ, Ghadamyari M, Alinia F, Etebari K: Diazinon resistance in different selected strains of Chilo suppressalis (Lepidoptera: Crambidae) in northern Iran. J Econ Entomol. 2009 Jun;102(3):1189-96. These biochemical characterizations of general esterases ALP, GST, and AChE were consistent with diazinon bioassay in the five populations. |
8(0,0,1,3) | Details |
| 10677267 | Dembele K, Haubruge E, Gaspar C: Concentration effects of selected insecticides on brain acetylcholinesterase in the common carp (Cyprinus carpio L.). Ecotoxicol Environ Saf. 2000 Jan;45(1):49-54. Hence, in the present study in vivo exposure period effect and in vitro concentration-response of chlorfenvinphos, chlorpyrifos diazinon, and carbofuran were investigated on Cyprinus carpio L. |
7(0,0,0,7) | Details |
| 19093198 | Scheil V, Kienle C, Osterauer R, Gerhardt A, Kohler HR: Effects of 3,4-dichloroaniline and diazinon on different biological organisation levels of zebrafish (Danio rerio) embryos and larvae. Ecotoxicology. 2009 Apr;18(3):355-63. Epub 2008 Dec 18. The toxicity of these substances with different modes of action (acetylcholine esterase inhibitor vs. polar narcosis) was tested for single substances as well as in binary mixtures. |
1(0,0,0,1) | Details |
| 12558165 | Denton DL, Wheelock CE, Murray SA, Deanovic LA, Hammock BD, Hinton DE: Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). Environ Toxicol Chem. 2003 Feb;22(2):336-41. After pesticide exposures, larvae were evaluated for carboxylesterase and acetylcholinesterase activity, and histopathological effects. |
1(0,0,0,1) | Details |
| 20149458 | Pereira Tridico C, Ferreira Rodrigues AC, Nogueira L, da Silva DC, Benedito Moreira A, de Almeida EA: Biochemical biomarkers in Oreochromis niloticus exposed to mixtures of benzo [a] pyrene and diazinon. Ecotoxicol Environ Saf. 2010 Feb 8. Biochemical biomarkers (the activities of acetylcholinesterase, 7-ethoxyresorufin-O-deetilase, carboxylesterase, catalase, peroxidase and glutathione S-transferase) were evaluated in Nile tilapia (Oreochromis niloticus) that had been exposed to benzo [a] pyrene (BaP) and the organophosphate pesticide diazinon (DZ), at 0.5mg/L. |
7(0,0,1,2) | Details |
| 20027669 | Musilek K, Dolezal M, Gunn-Moore F, Kuca K: Design, evaluation and structure-Activity relationship studies of the AChE reactivators against organophosphorus pesticides. Med Res Rev. 2009 Dec 21. Organophosphate pesticides (OPPs; e.g. chlorpyrifos, diazinon, paraoxon) are a wide and heterogeneous group of organophosphorus compounds. |
7(0,0,0,7) | Details |
| 10665412 | Galindo-Reyes JG, Dalla Venezia L, Lazcano-Alvarez G, Rivas-Mendoza H: Enzymatic and osmoregulative alterations in white shrimp Litopenaeus vannamei exposed to pesticides. Chemosphere. 2000 Feb;40(3):233-7. Enzymatic and osmoregulation tests in shrimp exposed to DDT, Lindane, Chlordane, Lorsban, Gusathion, Folidol, Diazinon and Tamaron were carried out. Activity reductions from 11 to 2 units/ml in acetylcholinesterase and from 1 to 0 units/l in transaminases (GOT and GPT) were detected. |
1(0,0,0,1) | Details |
| 17442507 | Ueyama J, Wang D, Kondo T, Saito I, Takagi K, Takagi K, Kamijima M, Nakajima T, Miyamoto K, Wakusawa S, Hasegawa T: Toxicity of diazinon and its metabolites increases in diabetic rats. Toxicol Lett. 2007 May 15;170(3):229-37. Epub 2007 Mar 24. The effect of diazinon (DZN) on the activities of cholinesterase (ChE) in plasma and acetylcholinesterase (AChE) in erythrocyte and brain was investigated in normal and streptozotocin-induced diabetic rats. |
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| 11113701 | Hatjian BA, Mutch E, Williams FM, Blain PG, Edwards JW: Cytogenetic response without changes in peripheral cholinesterase enzymes following exposure to a sheep dip containing diazinon in vivo and in vitro. Mutat Res. 2000 Dec 20;472(1-2):85-92. Occupational exposure to organophosphorus insecticides (OPs), such as diazinon, may be monitored by the measurement of the activity of peripheral cholinesterase enzymes, including erythrocyte acetylcholinesterase (EAChE) and plasma or serum cholinesterase (plasma or serum ChE). |
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| 7464033 | Hinkle DK, Suggs JE, Jackson MD: Environmental and biological effects following application of diazinon impregnated strips within a laboratory animal room. Lab Anim Sci. 1980 Dec;30(6):981-3. Erythrocyte acetylcholinesterase and plasma pseudocholinesterase activities were determined periodically. |
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| 10938544 | Kamal MA, Al-Jafari AA: Dual substrate model for novel approach towards a kinetic study of acetylcholinesterase inhibition by diazinon. J Enzyme Inhib. 2000;15(2):201-13. |
324(4,4,4,4) | Details |
| 11353139 | Hamm JT, Wilson BW, Hinton DE: Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). Toxicol Sci. 2001 Jun;61(2):304-13. Diazinon, an organophosphate pesticide, becomes biotransformed to a more potent oxon metabolite that inhibits acetylcholinesterase (AChE). |
203(2,3,4,8) | Details |
| 18700818 | Gaworecki KM, Roberts AP, Ellis N, Sowers AD, Klaine SJ: Biochemical and behavioral effects of diazinon exposure in hybrid striped bass. Environ Toxicol Chem. 2009 Jan;28(1):105-12. We hypothesized that sublethal exposure to diazinon, an organophosphate pesticide, may lead to feeding behavior abnormalities in hybrid striped bass (Morone saxatilis x M. chrysops) through inhibition of brain acetylcholinesterase (AChE) activity. |
165(2,2,2,5) | Details |
| 7481748 | Keizer J, D'Agostino G, Nagel R, Volpe T, Gnemi P, Vittozzi L: Enzymological differences of AChE and diazinon hepatic metabolism: correlation of in vitro data with the selective toxicity of diazinon to fish species. Sci Total Environ. 1995 Oct 27;171(1-3):213-20. |
131(1,2,5,6) | Details |
| 7469478 | Davies DB, Holub BJ: Toxicological evaluation of dietary diazinon in the rat. Arch Environ Contam Toxicol. 1980;9(6):637-50. For all feeding trials, plasma cholinesterase was a more sensitive indicator of diazinon toxicity compared to erythrocyte or brain acetylcholinesterase. |
6(0,0,1,1) | Details |
| 6451954 | Misawa M, Doull J, Kitos PA, Uyeki EM: Teratogenic effects of cholinergic insecticides in chick embryos. Toxicol Appl Pharmacol. 1981 Jan;57(1):20-9. Diazinon treatment on acetylcholinesterase and choline acetyltransferase activities. |
6(0,0,1,1) | Details |
| 7405825 | Hayes AL, Wise RA, Weir FW: Assessment of occupational exposure to organophosphates in pest control operators. Am Ind Hyg Assoc J. 1980 Aug;41(8):568-75. Measurements of 8-hour exposure levels were less than: 131.0 microgram/m3 for Vaponite; 41.0 microgram/m3 for Diazinon; and 27.6 microgram/m3 for Dursban. The effect of this exposure is reflected by a statistically significant inhibition of plasma acetylcholinesterase (AChE) among the PCOs as AChE values of either group. |
1(0,0,0,1) | Details |
| 9841812 | Pan G, Dutta HM: The inhibition of brain acetylcholinesterase activity of juvenile largemouth bass Micropterus salmoides by sublethal concentrations of diazinon. Environ Res. 1998 Nov;79(2):133-7. The results show that juvenile brain acetylcholinesterase activities were significantly inhibited by sublethal doses of diazinon. |
120(1,2,3,5) | Details |
| 17366821 | Jameson RR, Seidler FJ, Slotkin TA: Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon. Environ Health Perspect. 2007 Jan;115(1):65-70. OBJECTIVES: We exposed differentiating PC12 cells, a model for developing neurons, to 30 microM chlorpyrifos (CPF) or diazinon (DZN), or CPF oxon, the active metabolite that irreversibly inhibits AChE enzymatic activity, in order to determine whether they differentially induce the formation of AChE-S as a mechanistic predictor of developmental neurotoxicity. |
119(1,2,2,9) | Details |
| 12739815 | Hanna LS, Medhat AM, Abdel-Menem HA: Biochemical changes after subchronic and chronic interaction of Schistosoma mansoni infection in Swiss albino mice with two specific compounds. J Egypt Soc Parasitol. 2003 Apr;33(1):245-60. Effects of diazinon (DZN) and/or praziquantel (PZQ) on the levels of plasma (T3), (T4), activities of brain acetylcholinesterase (AchE) and liver alanine aminotransferase (ALT) in addition to blood (GSH) in healthy and S.m. infected mice were investigated after 9 and 17 weeks of either infection or intoxication with DZN. |
6(0,0,1,1) | Details |
| 20196151 | Oruc E: Effects of diazinon on antioxidant defense system and lipid peroxidation in the liver of Cyprinus carpio (L.). Environ Toxicol. 2010 Mar 1. To accomplish this aim, we studied the effects of sublethal concentrations (0.0036, 0.018, and 0.036 ppb) of diazinon on acetylcholine esterase activity, antioxidant enzyme activities, and lipid peroxidation in the liver of Cyprinus carpio on days 5, 15, and 30 after the exposure. |
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| 6138014 | Michalek H, Nemesio R, Meneguz A, Bisso GM: Interactions between anticholinesterase agents and neuroleptics in terms of cholinesterase inhibition in brain and other tissues of rats. Arch Toxicol Suppl. 1983;6:386-90. The enhanced inhibition of total ChE due to CPZ depended in most peripheral organs on the effect on pseudoChE (as measured by a spectrophotometric method), except in the case of skeletal muscle in which potentiation of PhS effect was observed on true acetylcholinesterase (AcChE). CPZ was found to potentiate slightly the effects of Mevinphos but did not interact with Carbaryl, Diazinon or Azinphos. |
1(0,0,0,1) | Details |
| 19674799 | Tryfonos M, Papaefthimiou C, Antonopoulou E, Theophilidis G: Comparing the inhibitory effects of five protoxicant organophosphates (azinphos-methyl, parathion-methyl, chlorpyriphos-methyl, methamidophos and diazinon) on the spontaneously beating auricle of Sparus aurata: an in vitro study. Aquat Toxicol. 2009 Sep 14;94(3):211-8. Epub 2009 Jul 16. Organophosphates (OPs) can provoke toxicity by inhibiting acetylcholinesterase (AChE) in non-target organisms, like fish. |
1(0,0,0,1) | Details |