| Name | 5HT transporter |
|---|---|
| Synonyms | Sodium dependent serotonin transporter; OCD1; 5 hydroxytryptamine transporter; 5HT transporter; 5HTT; HTT; OCD 1; SERT… |
| Name | diazinon |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17035140 | Slotkin TA, Tate CA, Ryde IT, Levin ED, Seidler FJ: Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ Health Perspect. 2006 Oct;114(10):1542-6. OBJECTIVES: We exposed neonatal rats to daily doses of diazinon or parathion on postnatal days (PND) 1-4 and evaluated 5HT receptors and the 5HT transporter in brainstem and forebrain on PND5, focusing on doses of each agent below the maximum tolerated dose and spanning the threshold for cholinesterase inhibition: 0.5, 1, or 2 mg/kg for diazinon, and 0.02, 0.05, and 0.1 mg/kg for parathion. |
82(1,1,1,2) | Details |
| 18835401 | Slotkin TA, Seidler FJ: Developmental neurotoxicants target neurodifferentiation into the phenotype: Chlorpyrifos, diazinon, dieldrin and divalent Toxicol Appl Pharmacol. 2008 Dec 1;233(2):211-9. Epub 2008 Sep 16. Chlorpyrifos and diazinon both induced tryptophan hydroxylase, the rate-limiting enzyme for 5HT biosynthesis, but chlorpyrifos had a greater effect, and both agents suppressed expression of 5HT transporter genes, effects that would tend to augment extracellular 5HT. |
81(1,1,1,1) | Details |
| 18355640 | Slotkin TA, Ryde IT, Levin ED, Seidler FJ: Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on systems in adolescence and adulthood. Brain Res Bull. 2008 Mar 28;75(5):640-7. Epub 2007 Nov 12. We then evaluated the effects on 5HT (1A) and 5HT (2) receptors, and on the 5HT transporter in cerebral cortical regions and the brainstem in adolescence through adulthood. |
1(0,0,0,1) | Details |