| Name | GTPase |
|---|---|
| Synonyms | RAC3; RAC3; Ras related C3 botulinum substrate 3; Ras related C3 botulinum toxin substrate 3; p21 Rac3; Ras related C3 botulinum substrate 3s; Ras related C3 botulinum toxin substrate 3s; p21 Rac3s… |
| Name | streptomycin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15004548 | Gromadski KB, Rodnina MV: Streptomycin interferes with conformational coupling between codon recognition and GTPase activation on the ribosome. Nat Struct Mol Biol. 2004 Apr;11(4):316-22. Epub 2004 Mar 7. |
81(1,1,1,1) | Details |
| 16843583 | Ninio J: Multiple stages in codon-anticodon recognition: double-trigger mechanisms and geometric constraints. Biochimie. 2006 Aug;88(8):963-92. Epub 2006 Jun 27. Streptomycin and most EF-Tu mutants as well as high accuracy ribosomal mutants would produce specific alterations at stage 2, which are mapped on the stage 2 kinetic mechanism. From the recent evidence on ribosome structure, it is conjectured that the L7/L12 flexible stalk of the large ribosome subunit acts as a proofreading gate, and that the alternation of its GTPase activation center between "TCase" competence and "BCase" competence is a main factor in the control of accuracy. |
1(0,0,0,1) | Details |
| 19095621 | Gregory ST, Carr JF, Dahlberg AE: A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA. RNA. 2009 Feb;15(2):208-14. Epub 2008 Dec 17. Three novel amino acid substitutions, H76R, R37C, and K53E in Thermus thermophilus ribosomal protein S12, confer resistance to streptomycin. A375T confers resistance to kirromycin, an antibiotic freezing EF-Tu in a GTPase activated state. |
1(0,0,0,1) | Details |