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streptomycin

Identification (Source:EPA,EU)

ID	360
Name	streptomycin
CAS	57-92-1
IUPAC
Inchi	InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1
CIPAC	312
EPA Code	006306
Formula	C21H39N7O12
SMILES	O([C@@H]1[C@@H]([C@H]([C@H](O)[C@H](O1)CO)O)NC)[C@@H]1[C@H](O[C@@H]([C@]1(C=O)O)C)O[C@@H]1[C@H]([C@@H]([C@@H](NC(N)=N)[C@@H]([C@H]1O)O)O)NC(N)=N
Status	Not Approved

Classification

Mode of Action	A aminoglycoside that inhibites protein biosynthesis, systemic action
Pesticide Type	Bactericide, Fungicide, Veterinary treatment
Chemical Group	Micro-organism derived
Classification	Bactericides antibiotic fungicides

Properties (Source:PubChem)

Molecular Weight	581.57
Physical State	White powder
AlogP	-6.291
H-Bond Donor	12
H-Bond Acceptor	19
Surface Area	570.2
Polar Surface Area	336.42

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	0.133 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	487 mg l-1
Mammals	Acute oral		LD50	> 9000 mg kg-1
Mammals	Acute oral		LD50	> 9000 mg kg-1

Related targets

Target Name	RScore (About this table)
muscles	344(4,4,4,24)	Details
S12	268(2,4,8,28)	Details
transferase	191(2,2,6,11)	Details
beta glucuronidase	167(2,2,2,7)	Details
ribosomal protein S12	181(1,2,11,26)	Details
interferon gamma	128(1,2,4,8)	Details
Toll like receptor 2	119(1,2,2,9)	Details
ASIC	114(1,2,2,4)	Details
VEGF	88(1,1,1,8)	Details
beta catenin	87(1,1,1,7)	Details
RP4	84(1,1,1,4)	Details
GTPase	83(1,1,1,3)	Details
tem 1	83(1,1,1,3)	Details
NHE1	83(1,1,1,3)	Details
SP2	82(1,1,1,2)	Details
Tat protein	81(1,1,1,1)	Details
FVIII	81(1,1,1,1)	Details
immunoglobulin (protein family or complex)	81(1,1,1,1)	Details
TH1	81(1,1,1,1)	Details
aph 2	125(0,1,12,40)	Details
F12	71(0,1,7,11)	Details
dihydrofolate reductase	70(0,1,7,10)	Details
EF Tu	50(0,1,3,10)	Details
calcineurin (protein family or complex)	40(0,1,1,10)	Details
IS1	35(0,1,1,5)	Details
caspase 1	35(0,1,1,5)	Details
GM133	34(0,1,1,4)	Details
Potassium channel (protein family or complex)	34(0,1,1,4)	Details
caspase 8	34(0,1,1,4)	Details
TLR4	34(0,1,1,4)	Details
angiotensin II	33(0,1,1,3)	Details
p65 protein	33(0,1,1,3)	Details
sulfonylurea receptor	33(0,1,1,3)	Details
interleukin 18	33(0,1,1,3)	Details
A10	32(0,1,1,2)	Details
plasminogen	32(0,1,1,2)	Details
phosphoserine phosphatase	32(0,1,1,2)	Details
B17	31(0,1,1,1)	Details
desmin	31(0,1,1,1)	Details
Kir6.2	31(0,1,1,1)	Details
acylase	31(0,1,1,1)	Details
AT1	31(0,1,1,1)	Details
polymerases	31(0,1,1,1)	Details
caspase 9	31(0,1,1,1)	Details
caspase 6	31(0,1,1,1)	Details
interleukin 12	31(0,1,1,1)	Details
PFGE	204(0,0,1,199)	Details
transferrin	24(0,0,4,4)	Details
ribosomal proteins (protein family or complex)	22(0,0,2,12)	Details
epidermal growth factor	22(0,0,3,7)	Details
prion protein	21(0,0,3,6)	Details
interleukin 10	20(0,0,2,10)	Details
interleukin 17	20(0,0,2,10)	Details
Rev 1	19(0,0,2,9)	Details
Nramp1	16(0,0,1,11)	Details
basic fibroblast growth factor	16(0,0,2,6)	Details
lactase	15(0,0,2,5)	Details
ant 3	15(0,0,2,5)	Details
CD4	14(0,0,0,14)	Details
follicle stimulating hormone (protein family or complex)	14(0,0,2,4)	Details
Nerve growth factor	14(0,0,2,4)	Details
gelatinase	13(0,0,0,13)	Details
B27	13(0,0,2,3)	Details
IL 23	11(0,0,1,6)	Details
beaches	10(0,0,1,5)	Details
interleukin 22	10(0,0,1,5)	Details
chemokine	10(0,0,1,5)	Details
lipase	9(0,0,1,4)	Details
C18	9(0,0,1,4)	Details
fatty acid desaturase	9(0,0,0,9)	Details
hemolysin	9(0,0,0,9)	Details
ant 4	9(0,0,0,9)	Details

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