Protein Information

Name caspase 8
Synonyms Apoptotic cysteine protease; Apoptotic protease Mch 5; CAP 4; CAP4; CASP 8; CASP8; CASP8 protein; Caspase 8…

Compound Information

Name streptomycin
CAS

Reference List

PubMed Abstract RScore(About this table)
19954022 He JC, Yu DZ, Ding DL, Yin SK, Salvi RJ: [Streptomycin-induced apoptosis of rat cochlear hair cell cultured in vitro]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jun;44(6):494-8.

After streptomycin treatment, the nuclear shrinkage and fragmentation were found in most cochlear hair cells, and the caspase-8, caspase-9 and caspase-6 were greatly activated.
32(0,1,1,2) Details
17962376 Liu J, Matsuo H, Laoag-Fernandez JB, Xu Q, Maruo T: The effects of progesterone on apoptosis in the human trophoblast-derived HTR-8/SV neo cells. Mol Hum Reprod. 2007 Dec;13(12):869-74. Epub 2007 Oct 25.

The HTR-8/SV neo cells were cultured in RPMI 1640 medium supplemented with 10% fetal bovine serum, 100 U/ml penicillin and 100 microg/ml streptomycin.
Compared with untreated cultures, treatment with P4 (10 and 100 ng/ml) resulted in significant decreases in the TUNEL-positive rate, Fas, Fas ligand (Fas-L), caspase-8, caspase-3 and poly (ADP-ribose) polymerase (PARP) expression in HTR-8/SV neo cells, and a significant increase in Bcl-2 expression in those cells.
2(0,0,0,2) Details