| Name | S12 |
|---|---|
| Synonyms | 5 HT 1B; S12; 5 HT 1D beta; 5 HT1B; 5 HT1DB; 5 hydroxytryptamine (serotonin) receptor 1B; 5 hydroxytryptamine 1B receptor; HTR1B… |
| Name | streptomycin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17027976 | Golovin A, Spiridonova V, Kopylov A: Mapping contacts of the S12-S7 intercistronic region of str operon mRNA with ribosomal protein S7 of E. coli. FEBS Lett. 2006 Oct 30;580(25):5858-62. Epub 2006 Oct 2. It also regulates translation of the S12 and S7 cistrons of the 'streptomycin' operon transcript by binding to the S12-S7 intercistronic region. |
83(1,1,1,3) | Details |
| 19553343 | Llano-Sotelo B, Hickerson RP, Lancaster L, Noller HF, Mankin AS: Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding. RNA. 2009 Aug;15(8):1597-604. Epub 2009 Jun 24. The fluorescence characteristics of the reconstituted subunits were affected by several antibiotics, including streptomycin and neomycin, which bind in the vicinity of protein S12. |
82(1,1,1,2) | Details |
| 18620530 | Surdina AV, Rassokhin TI, Golovin AV, Spiridonova VA, Kraal B, Kopylov AM: Selection of random RNA fragments as method for searching for a site of regulation of translation of E. coli streptomycin mRNA by ribosomal protein S7. Biochemistry. 2008 Jun;73(6):652-9. During shift-down of rRNA synthesis level, free S7 inhibits self-translation by interacting with 96 nucleotides long specific region of streptomycin (str) mRNA between cistrons S12 and S7 (intercistron). |
32(0,1,1,2) | Details |
| 18201202 | Aoki H, Xu J, Emili A, Chosay JG, Golshani A, Ganoza MC: Interactions of elongation factor EF-P with the Escherichia coli ribosome. FEBS J. 2008 Feb;275(4):671-81. Epub 2008 Jan 12. We report that EF-P protects 16S rRNA near the G526 streptomycin and the S12 and mRNA binding sites (30S T-site). |
31(0,1,1,1) | Details |
| 17512991 | Vila-Sanjurjo A, Lu Y, Aragonez JL, Starkweather RE, Sasikumar M, O'Connor M: Modulation of 16S rRNA function by ribosomal protein S12. . Biochim Biophys Acta. 2007 Jul-Aug;1769(7-8):462-71. Epub 2007 Apr 20. Genetic selection of suppressors of streptomycin dependence caused by mutations at 90 in S12 yielded a C912U substitution in 16S rRNA. |
9(0,0,1,4) | Details |
| 17157877 | Maisnier-Patin S, Paulander W, Pennhag A, Andersson DI: Compensatory evolution reveals functional interactions between ribosomal proteins S12, L14 and L19. J Mol Biol. 2007 Feb 9;366(1):207-15. Epub 2006 Nov 15. Certain mutations in S12, a ribosomal protein involved in translation elongation rate and translation accuracy, confer resistance to the aminoglycoside streptomycin. |
9(0,0,1,4) | Details |
| 15009191 | Chumpolkulwong N, Hori-Takemoto C, Hosaka T, Inaoka T, Kigawa T, Shirouzu M, Ochi K, Yokoyama S: Effects of Escherichia coli ribosomal protein S12 mutations on cell-free protein synthesis. Eur J Biochem. 2004 Mar;271(6):1127-34. By screening 150 spontaneous streptomycin-resistant isolates from E. coli BL21, we successfully obtained seven mutants of the S12 protein, including two streptomycin-dependent mutants. |
6(0,0,1,1) | Details |
| 17601820 | Blas-Galindo E, Cava F, Lopez-Vinas E, Mendieta J, Berenguer J: Use of a dominant rpsL allele conferring streptomycin dependence for positive and negative selection in Thermus thermophilus. Appl Environ Microbiol. 2007 Aug;73(16):5138-45. Epub 2007 Jun 29. This new allele, named rpsL1, encodes a K47R/K57E double mutant S12 ribosomal protein that confers a streptomycin-dependent (SD) phenotype to T. thermophilus. |
6(0,0,1,1) | Details |
| 17967466 | Sharma D, Cukras AR, Rogers EJ, Southworth DR, Green R: Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol. 2007 Dec 7;374(4):1065-76. Epub 2007 Oct 6. The aminoglycosides paromomycin and streptomycin bind to the decoding center and induce related structural rearrangements that explain their observed effects on miscoding. |
4(0,0,0,4) | Details |
| 15332709 | Gill AE, Amyes SG: The contribution of a novel ribosomal S12 mutation to aminoglycoside resistance of Escherichia coli mutants. J Chemother. 2004 Aug;16(4):347-9. Mutants of E. coli NCTC 10418 were selected in four separate progressive series (I-IV) on plates containing increasing aminoglycoside (streptomycin, neomycin, gentamicin, tobramycin, and kanamycin) concentrations. |
2(0,0,0,2) | Details |
| 19095621 | Gregory ST, Carr JF, Dahlberg AE: A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA. RNA. 2009 Feb;15(2):208-14. Epub 2008 Dec 17. Here, we present genetic evidence that a specific set of direct interactions between ribosomal protein S12 and aminoacyl-tRNA, together with contacts between S12 and 16S rRNA, provide a pathway for the signaling of codon recognition to EF-Tu. Three novel amino acid substitutions, H76R, R37C, and K53E in Thermus thermophilus ribosomal protein S12, confer resistance to streptomycin. |
2(0,0,0,2) | Details |
| 19966024 | Drecktrah D, Douglas JM, Samuels DS: Use of rpsL as a Counterselectable Marker in Borrelia burgdorferi. Appl Environ Microbiol. 2010 Feb;76(3):985-7. Epub 2009 Dec 4. We have demonstrated that rpsL, encoding the S12 protein of the small ribosomal subunit, can be used as a counterselectable marker in Borrelia burgdorferi, the causative agent of Lyme disease. Mutations in rpsL confer streptomycin resistance. |
1(0,0,0,1) | Details |
| 16391027 | Kurosawa K, Hosaka T, Tamehiro N, Inaoka T, Ochi K: Improvement of alpha-amylase production by modulation of ribosomal component protein S12 in Bacillus subtilis 168. Appl Environ Microbiol. 2006 Jan;72(1):71-7. Here we show that introduction of mutations that produce streptomycin resistance (str) also enhances alpha-amylase (and protease) production by a strain of Bacillus subtilis as estimated by measuring the enzyme activity. |
1(0,0,0,1) | Details |
| 16484214 | Carr JF, Hamburg DM, Gregory ST, Limbach PA, Dahlberg AE: Effects of streptomycin resistance mutations on posttranslational modification of ribosomal protein S12. J Bacteriol. 2006 Mar;188(5):2020-3. |
0(0,0,0,0) | Details |