| Name | ribosomal proteins (protein family or complex) |
|---|---|
| Synonyms | Ribosomal protein; Ribosomal proteins |
| Name | streptomycin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17157877 | Maisnier-Patin S, Paulander W, Pennhag A, Andersson DI: Compensatory evolution reveals functional interactions between ribosomal proteins S12, L14 and L19. J Mol Biol. 2007 Feb 9;366(1):207-15. Epub 2006 Nov 15. Certain mutations in S12, a ribosomal protein involved in translation elongation rate and translation accuracy, confer resistance to the aminoglycoside streptomycin. |
9(0,0,1,4) | Details |
| 17601820 | Blas-Galindo E, Cava F, Lopez-Vinas E, Mendieta J, Berenguer J: Use of a dominant rpsL allele conferring streptomycin dependence for positive and negative selection in Thermus thermophilus. Appl Environ Microbiol. 2007 Aug;73(16):5138-45. Epub 2007 Jun 29. This new allele, named rpsL1, encodes a K47R/K57E double mutant S12 ribosomal protein that confers a streptomycin-dependent (SD) phenotype to T. thermophilus. |
6(0,0,1,1) | Details |
| 16476727 | Higashi K, Kashiwagi K, Taniguchi S, Terui Y, Yamamoto K, Ishihama A, Igarashi K: Enhancement of +1 frameshift by polyamines during translation of polypeptide release factor 2 in Escherichia coli. J Biol Chem. 2006 Apr 7;281(14):9527-37. Epub 2006 Feb 13. Spectinomycin, tetracycline, streptomycin, and neomycin reduced polyamine stimulation of the +1 frameshift of RF2 synthesis. The level of mRNAs of ribosomal proteins and elongation factors having UAA as termination codon was enhanced by polyamines, and OppA synthesis from OppA mRNA having UAA as termination codon was more enhanced by polyamines than that from OppA mRNA having a UGA termination codon. |
2(0,0,0,2) | Details |
| 19553343 | Llano-Sotelo B, Hickerson RP, Lancaster L, Noller HF, Mankin AS: Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding. RNA. 2009 Aug;15(8):1597-604. Epub 2009 Jun 24. Here, we describe a general method for studying binding of ligands to ribosomes that carry a site-specific fluorescent label covalently attached to one of the ribosomal proteins. The fluorescence characteristics of the reconstituted subunits were affected by several antibiotics, including streptomycin and neomycin, which bind in the vicinity of protein S12. |
1(0,0,0,1) | Details |
| 17116475 | Wirmer J, Westhof E: Molecular contacts between antibiotics and the 30S ribosomal particle. Methods Enzymol. 2006;415:180-202. The crystal structures of complexes between various antibiotics and ribosomal particles show definitively that ribosomal RNAs (rRNAs), rather than ribosomal proteins, are overwhelmingly targeted. Structurally, the antibiotics interact in many ways with RNA: (i) only with the groups (streptomycin); (ii) mainly with bases (hygromycin, spectinomycin); (iii) with a mixture of both (paromomycin, Geneticin); (iv) via (tetracycline) or a protein side chain (streptomycin). |
1(0,0,0,1) | Details |
| 16481518 | Rolain JM, Raoult D: Genome comparison analysis of molecular mechanisms of resistance to antibiotics in the Rickettsia genus. Ann N Y Acad Sci. 2005 Dec;1063:222-30. Apart from the mutations in the rpoB gene in naturally rifampin-resistant Rickettsia species previously reported by our team, we found that typhus group (TG) rickettsiae had a triple amino acid difference in the highly conserved region of the L22 ribosomal protein as compared to the spotted fever group rickettsiae (SFG), which could explain the natural resistance of SFG rickettsia to erythromycin. Five specific ORFs related to antibiotic resistance have been identified in the genome of R. felis including a streptomycin resistance protein homologue, a class C beta-lactamase, a class D beta-lactamase, a penicillin acylase homologue, and an ABC-type multidrug transporter system. |
1(0,0,0,1) | Details |
| 19386726 | Vallabhaneni H, Farabaugh PJ: Accuracy modulating mutations of the ribosomal protein S4-S5 interface do not necessarily destabilize the rps4-rps5 protein-protein interaction. RNA. 2009 Jun;15(6):1100-9. Epub 2009 Apr 22. We used a yeast two-hybrid system to study the interactions between the small subunit ribosomal proteins rpS4 and rpS5 and to test the effect of ram mutations on the stability of the interface. Though selection is usually accurate, mutations in the ribosomal RNA and proteins and the presence of some antibiotics like streptomycin alter translational accuracy. |
1(0,0,0,1) | Details |
| 17095544 | Kramer EB, Farabaugh PJ: The frequency of translational misreading errors in E. coli is largely determined by tRNA competition. RNA. 2007 Jan;13(1):87-96. Epub 2006 Nov 9. We also used the system to study the effect of ribosomal protein mutations known to affect error rates and the effect of error-inducing antibiotics, finding that they affect misreading on only a subset of near-cognate codons and that their effect may be less general than previously thought. |
1(0,0,0,1) | Details |
| 19776006 | Holberger LE, Hayes CS: Ribosomal protein S12 and aminoglycoside antibiotics modulate A-site mRNA cleavage and transfer-messenger RNA activity in Escherichia coli. J Biol Chem. 2009 Nov 13;284(46):32188-200. Epub 2009 Sep 23. Here, we demonstrate that the aminoglycosides paromomycin and streptomycin inhibit A-site cleavage of stop codons during inefficient translation termination. |
0(0,0,0,0) | Details |
| 16626740 | Liou GF, Yoshizawa S, Courvalin P, Galimand M: Aminoglycoside resistance by ArmA-mediated ribosomal 16S methylation in human bacterial pathogens. J Mol Biol. 2006 Jun 2;359(2):358-64. Epub 2006 Mar 31. Methylation of the ribosomal target is an emerging mechanism that produces a high level of resistance to all clinically available aminoglycosides for systemic therapy except streptomycin. |
0(0,0,0,0) | Details |