Protein Information

Name IS1
Synonyms AIS; AIS1; AIS 1; IS1

Compound Information

Name streptomycin
CAS

Reference List

PubMed Abstract RScore(About this table)
17106514 Kharat AS, Coursange E, Noirclerc-Savoye M, Lacoste J, Blot M: IS1 transposition is enhanced by translation errors and by bacterial growth at extreme glucose levels. Acta Biochim Pol. 2006;53(4):729-38. Epub 2006 Nov 14.

Using a reporter system which involves the activation of the cryptic bgl operon in Escherichia coli, we show that the frequency of IS1 transposition is a function of glucose concentration in the growth medium, it is increased by streptomycin amounts that are below minimum inhibitory concentration (sub-MIC) and is inhibited in an rpsL150 strain with high translation accuracy.
33(0,1,1,3) Details
16782743 Peirano G, Agerso Y, Aarestrup FM, dos Reis EM, dos Prazeres Rodrigues D: Occurrence of integrons and antimicrobial resistance genes among Salmonella enterica from Brazil. J Antimicrob Chemother. 2006 Aug;58(2):305-9. Epub 2006 Jun 16.

Sulphonamide resistance was primarily mediated by sul2 and sul3, tetracycline resistance by tet (B) and tet (A), chloramphenicol resistance by catA1, streptomycin resistance by strA and ampicillin resistance by blaTEM. blaCTX and blaCMY-2 were found in cephalosporin-resistant isolates.
The gene cassette arrangements could be determined in 51 of the positive isolates, which harboured one [dfrA22, aadA1 or orf3 (putative trimethoprim resistance)], two [aadA1-dfrA1, aac (6')-Ib-orf1 (unknown function) or aacA4-aadA1], three [dfrA15b-cmlA4-aadA2, orf2 (unknown function)-dfrA5-orfD] or four [orf4-aacA4-blaOXA-30 (interrupted by an IS1 element)-aadA1] cassettes in their variable region.
1(0,0,0,1) Details
17242143 Dubois V, Parizano MP, Arpin C, Coulange L, Bezian MC, Quentin C: High genetic stability of integrons in clinical isolates of Shigella spp. of worldwide origin. Antimicrob Agents Chemother. 2007 Apr;51(4):1333-40. Epub 2007 Jan 22.

These strains were often resistant (streptomycin, spectinomycin, trimethoprim, tetracycline, and sulfonamides, 66 to 84%; ampicillin and chloramphenicol, 34 to 38%; nalidixic acid, 4%) and even multiresistant (87%), and they generally carried integrons (81%) of class 1 (21%), class 2 (47%), or both (13%).
Class 1 integrons showed an atypical organization consisting of the insertion sequence IS1 at the 3' end instead of the typical 3' conserved segment and two blaOXA-30 and aadA1 gene cassettes, despite the absence of epidemiological relationships between the strains, and an apparently functional integrase.
1(0,0,0,1) Details