Protein Information

Name TLR4
Synonyms CD284; CD284 antigen; TLR 4; TLR4; TOLL; Toll like receptor 4; Toll like receptor 4 precursor; hToll…

Compound Information

Name streptomycin
CAS

Reference List

PubMed Abstract RScore(About this table)
20300949 Umenai T, Hirai H, Shime N, Nakaya T, Asahara T, Nomoto K, Kita M, Tanaka Y, Imanishi J: Eradication of the commensal intestinal microflora by oral antimicrobials interferes with the host response to lipopolysaccharide. Eur J Clin Microbiol Infect Dis. 2010 Mar 20.

We studied the expression and function of TLR4 and TLR2 on alveolar and peritoneal macrophages in mice after 3 weeks of oral administration of streptomycin and cefotaxime.
33(0,1,1,3) Details
18832584 Calderon Toledo C, Rogers TJ, Svensson M, Tati R, Fischer H, Svanborg C, Karpman D: Shiga toxin-mediated disease in MyD88-deficient mice infected with Escherichia coli O157:H7. Am J Pathol. 2008 Nov;173(5):1428-39. Epub 2008 Oct 2.

TLR4 can mediate a response through adaptor molecules, MyD88 or TRIF.
In the present study, streptomycin-treated MyD88 (-/-), Tlr4 (-/-), Trif (Lps2/Lps2), and C57BL/6 wild-type (WT) mice were infected with either Shiga toxin (Stx)-producing or non-producing Escherichia coli O157:H7.
1(0,0,0,1) Details