Protein Information

Name immunoglobulin (protein family or complex)
Synonyms Immunoglobulin; Immunoglobulins

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
8654188 Hosokawa M, Endo T, Fujisawa M, Hara S, Iwata N, Sato Y, Satoh T: Interindividual variation in carboxylesterase levels in human liver microsomes. Drug Metab Dispos. 1995 Oct;23(10):1022-7.

Microsomal carboxylesterase activities in 12 human livers were determined using 10 kinds of carboxylesterase substrates (p-nitrophenylacetate, p-nitrophenylpropionate, p-nitrophenylbutyrate, butanilicaine, isocarboxazid, palmitoyl-coenzyme-A, malathion, clofibrate, acetanilide, and phenacetin).
The RH1-immunoreactive carboxylesterase concentration correlated well with those of p-nitrophenylesters, clofibrate, butanilicaine, and isocarboxazid, and anti-RH1 immunoglobulin G strongly inhibited human liver hydrolase activity.
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17139545 Sodhi S, Sharma A, Brar RS: A protective effect of vitamin E and selenium in ameliorating the immunotoxicity of malathion in chicks. Vet Res Commun. 2006 Nov;30(8):935-42.

The concentration of total immunoglobulins and circulatory immune complexes decreased following the administration of malathion, whereas the supplementation of the diet with vitamin E and selenium partially counteracted this effect.
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2430350 Kashyap SK: Health surveillance and biological monitoring of pesticide formulators in India. Toxicol Lett. 1986 Oct;33(1-3):107-14.

Exposure of 160 workers to a combination of pesticides (malathion, parathion, DDT and HCH) resulted in 73% of the workers showing toxic signs and symptoms.
Changes in the liver enzymes ornithine carbamyl transferase (OCT), gamma-glutamyl transpeptidase (GGTP), leucine aminopeptidase (LAP) and in immunoglobulin M (IgM) showed possible effects on liver and humoral immunity.
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9754060 Banerjee BD, Pasha ST, Hussain QZ, Koner BC, Ray A: A comparative evaluation of immunotoxicity of malathion after subchronic exposure in experimental animals. Indian J Exp Biol. 1998 Mar;36(3):273-82.

The humoral immune response was assessed by estimating serum immunoglobulin (IgM and IgG) concentrations, antibody titre against antigens and splenic-plaque forming cells (PFC).
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