malathion
Identification (Source:EPA,EU)
ID |
222 |
Name |
malathion |
CAS |
121-75-5 |
IUPAC |
|
Inchi |
InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3 |
CIPAC |
12 |
EPA Code |
|
Formula |
C10H19O6PS2 |
SMILES |
O=C(OCC)C(SP(=S)(OC)OC)CC(=O)OCC |
Status |
Approved |
Classification
Properties (Source:PubChem)
Molecular Weight |
330.36 |
Physical State |
Clear to amber liquid |
AlogP |
1.787 |
H-Bond Donor |
0 |
H-Bond Acceptor |
8 |
Surface Area |
328.29 |
Polar Surface Area |
138.26 |
Structure
Ecotoxicology (Source:PPDB,IPM)
Species |
Method |
Study Time |
Dose Type |
Value |
Algae |
Acute |
72 hour |
EC50, growth |
13 mg l-1 |
Aquatic crustaceans |
Acute |
96 hour |
LC50 |
0.0015 mg l-1 |
Aquatic invertebrates |
Acute |
48 hour |
EC50 |
0.0007 mg l-1 |
Aquatic invertebrates |
Chronic |
21 day |
NOEC |
0.00006 mg l-1 |
Birds |
Acute |
|
LD50 |
359 mg kg-1 |
Birds |
Short term dietary |
|
LC50/LD50 |
554 mg/kg bw/day |
Earthworms |
Acute |
14 day |
LD50 |
306 mg kg-1 |
Fish |
Chronic |
21 day |
NOEC |
0.091 mg l-1 |
Fish |
Acute |
96 hour |
LC50 |
0.018 mg l-1 |
Honeybees |
Acute |
48 hour |
LD50 |
0.16 μg bee-1 |
Mammals |
Acute oral |
|
LD50 |
1178 mg kg-1 |
Mammals |
Short term dietary |
|
NOEL |
34.4 mg kg-1 |
Sediment dwelling organisms |
Acute |
96 hour |
LC50 |
0.0004 mg l-1 |
|
Bio-concentration factor |
|
CT50 |
0.69 days |
|
Bio-concentration factor |
|
BCF |
103 |
Related targets
Target Name |
RScore (About this table) |
|
Acetylcholinesterase
|
5672(44,88,152,512) |
Details |
serum cholinesterase
|
1632(11,25,48,217) |
Details |
lysyl hydroxylase
|
438(5,6,6,8) |
Details |
cytochrome P450 (protein family or complex)
|
421(4,6,8,31) |
Details |
glutathione reductase
|
311(3,4,10,11) |
Details |
SRBC
|
283(3,4,4,13) |
Details |
cathepsin D
|
274(3,4,4,4) |
Details |
caspase (protein family or complex)
|
225(2,4,4,5) |
Details |
IgE
|
170(2,2,3,5) |
Details |
glutathione S transferase
|
343(1,6,18,53) |
Details |
glucokinase
|
112(1,2,2,2) |
Details |
ATPase
|
100(1,1,3,10) |
Details |
immunoglobulin (protein family or complex)
|
84(1,1,1,4) |
Details |
INAP
|
84(1,1,1,4) |
Details |
CYP1A2
|
82(1,1,1,2) |
Details |
E cadherin
|
82(1,1,1,2) |
Details |
beta catenin
|
82(1,1,1,2) |
Details |
ceruloplasmin
|
81(1,1,1,1) |
Details |
polymerases
|
81(1,1,1,1) |
Details |
interleukin 4
|
81(1,1,1,1) |
Details |
interleukin 1
|
81(1,1,1,1) |
Details |
lysyl oxidase
|
81(1,1,1,1) |
Details |
arginase
|
81(1,1,1,1) |
Details |
caspase 3
|
81(1,1,1,1) |
Details |
HK1
|
81(1,1,1,1) |
Details |
alkaline phosphatase
|
107(0,3,4,12) |
Details |
HSP27
|
75(0,2,4,5) |
Details |
Paraoxonase
|
71(0,2,2,11) |
Details |
superoxide dismutase
|
94(0,1,10,19) |
Details |
catalase
|
83(0,1,8,18) |
Details |
albumin
|
50(0,1,1,20) |
Details |
acid phosphatase
|
48(0,1,2,13) |
Details |
beta hexosaminidase
|
46(0,1,3,6) |
Details |
transferase
|
42(0,1,2,7) |
Details |
glutathione transferase
|
41(0,1,2,6) |
Details |
sodium channel (protein family or complex)
|
40(0,1,2,5) |
Details |
lactate dehydrogenase (protein family or complex)
|
37(0,1,1,7) |
Details |
CYP3A
|
37(0,1,1,7) |
Details |
calmodulin
|
35(0,1,1,5) |
Details |
cytochrome P450 monooxygenase
|
35(0,1,1,5) |
Details |
CYP2D6
|
33(0,1,1,3) |
Details |
estrogen receptor alpha
|
33(0,1,1,3) |
Details |
CYP1A1
|
33(0,1,1,3) |
Details |
CYP2C9
|
32(0,1,1,2) |
Details |
phosphodiesterase
|
32(0,1,1,2) |
Details |
caspase 8
|
31(0,1,1,1) |
Details |
glutamine synthetase
|
31(0,1,1,1) |
Details |
tumor necrosis factor
|
31(0,1,1,1) |
Details |
CYP2C8
|
31(0,1,1,1) |
Details |
HSP60
|
31(0,1,1,1) |
Details |
PCNA
|
31(0,1,1,1) |
Details |
interferon (protein family or complex)
|
31(0,1,1,1) |
Details |
intestinal alkaline phosphatase
|
31(0,1,1,1) |
Details |
caspase 9
|
31(0,1,1,1) |
Details |
glutaminase
|
31(0,1,1,1) |
Details |
BP75
|
31(0,1,1,1) |
Details |
CYP2B6
|
31(0,1,1,1) |
Details |
ribosomal protein S5
|
31(0,1,1,1) |
Details |
muscles
|
37(0,0,4,17) |
Details |
epoxide hydrolase
|
20(0,0,3,5) |
Details |
glucose 6 phosphate dehydrogenase
|
19(0,0,2,9) |
Details |
casein
|
19(0,0,3,4) |
Details |
metallothionein (protein family or complex)
|
18(0,0,3,3) |
Details |
C18
|
17(0,0,1,12) |
Details |
glycogen phosphorylase
|
16(0,0,2,6) |
Details |
Ha ras
|
15(0,0,2,5) |
Details |
ER1
|
12(0,0,2,2) |
Details |
liver carboxylesterase
|
12(0,0,1,7) |
Details |
HC5
|
11(0,0,1,6) |
Details |
Glutamate pyruvate transaminase
|
11(0,0,1,6) |
Details |
RL1
|
11(0,0,1,6) |
Details |
A14
|
10(0,0,1,5) |
Details |
beta glucuronidase
|
10(0,0,1,5) |
Details |
glutamyl transpeptidase
|
9(0,0,1,4) |
Details |
cardiac troponin I
|
9(0,0,0,9) |
Details |
prothrombin
|
9(0,0,1,4) |
Details |
ASAT
|
8(0,0,1,3) |
Details |
aryl hydrocarbon hydroxylase
|
8(0,0,1,3) |
Details |
glucose 6 phosphatase
|
8(0,0,1,3) |
Details |
hexokinase
|
8(0,0,1,3) |
Details |
per 1
|
7(0,0,1,2) |
Details |
brains
|
7(0,0,1,2) |
Details |
phosphoenolpyruvate carboxykinase
|
7(0,0,1,2) |
Details |
esterase B3
|
7(0,0,1,2) |
Details |
PEPCK
|
7(0,0,1,2) |
Details |
protein as
|
6(0,0,1,1) |
Details |
cream 1
|
6(0,0,1,1) |
Details |
DEF6
|
6(0,0,1,1) |
Details |
at protein
|
6(0,0,1,1) |
Details |
glutathione S alkyltransferase
|
6(0,0,1,1) |
Details |
MCM2
|
6(0,0,1,1) |
Details |
Anas
|
6(0,0,1,1) |
Details |
corticotropin releasing hormone
|
6(0,0,1,1) |
Details |
ppt 1
|
6(0,0,1,1) |
Details |
ACh 2
|
6(0,0,1,1) |
Details |
and 1 protein
|
6(0,0,1,1) |
Details |
follicle stimulating hormone (protein family or complex)
|
6(0,0,1,1) |
Details |
DVL1
|
6(0,0,1,1) |
Details |
neurotoxic esterase
|
6(0,0,0,6) |
Details |
brain 2
|
6(0,0,1,1) |
Details |
CF 1 (protein family or complex)
|
6(0,0,1,1) |
Details |
myoglobin
|
6(0,0,0,6) |
Details |
TP53
|
6(0,0,1,1) |
Details |
glucose 6 phosphatases (protein family or complex)
|
6(0,0,1,1) |
Details |
progestins (protein family or complex)
|
6(0,0,1,1) |
Details |
glycophorin A
|
6(0,0,1,1) |
Details |
plasminogen
|
4(0,0,0,4) |
Details |
interleukin 2
|
4(0,0,0,4) |
Details |
hemoglobin (protein family or complex)
|
4(0,0,0,4) |
Details |
ace 1
|
4(0,0,0,4) |
Details |
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