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malathion

Identification (Source:EPA,EU)

ID	222
Name	malathion
CAS	121-75-5
IUPAC
Inchi	InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3
CIPAC	12
EPA Code
Formula	C10H19O6PS2
SMILES	O=C(OCC)C(SP(=S)(OC)OC)CC(=O)OCC
Status	Approved

Classification

Mode of Action	Broad-spectrum, non-systemic with contact, stomach and respiratory action. Acetylcholinesterase (AChE) inhibitor.
Pesticide Type	Insecticide, Acaricide, Veterinary treatment
Chemical Group	Organophosphate
Classification	organothiophosphate insecticides organothiophosphate acaricides aliphatic organothiophosphate insecticides

Properties (Source:PubChem)

Molecular Weight	330.36
Physical State	Clear to amber liquid
AlogP	1.787
H-Bond Donor	0
H-Bond Acceptor	8
Surface Area	328.29
Polar Surface Area	138.26

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	13 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.0015 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.0007 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.00006 mg l-1
Birds	Acute		LD50	359 mg kg-1
Birds	Short term dietary		LC50/LD50	554 mg/kg bw/day
Earthworms	Acute	14 day	LD50	306 mg kg-1
Fish	Chronic	21 day	NOEC	0.091 mg l-1
Fish	Acute	96 hour	LC50	0.018 mg l-1
Honeybees	Acute	48 hour	LD50	0.16 μg bee-1
Mammals	Acute oral		LD50	1178 mg kg-1
Mammals	Short term dietary		NOEL	34.4 mg kg-1
Sediment dwelling organisms	Acute	96 hour	LC50	0.0004 mg l-1
	Bio-concentration factor		CT50	0.69 days
	Bio-concentration factor		BCF	103

Related targets

Target Name	RScore (About this table)
Acetylcholinesterase	5672(44,88,152,512)	Details
serum cholinesterase	1632(11,25,48,217)	Details
lysyl hydroxylase	438(5,6,6,8)	Details
cytochrome P450 (protein family or complex)	421(4,6,8,31)	Details
glutathione reductase	311(3,4,10,11)	Details
SRBC	283(3,4,4,13)	Details
cathepsin D	274(3,4,4,4)	Details
caspase (protein family or complex)	225(2,4,4,5)	Details
IgE	170(2,2,3,5)	Details
glutathione S transferase	343(1,6,18,53)	Details
glucokinase	112(1,2,2,2)	Details
ATPase	100(1,1,3,10)	Details
immunoglobulin (protein family or complex)	84(1,1,1,4)	Details
INAP	84(1,1,1,4)	Details
CYP1A2	82(1,1,1,2)	Details
E cadherin	82(1,1,1,2)	Details
beta catenin	82(1,1,1,2)	Details
ceruloplasmin	81(1,1,1,1)	Details
polymerases	81(1,1,1,1)	Details
interleukin 4	81(1,1,1,1)	Details
interleukin 1	81(1,1,1,1)	Details
lysyl oxidase	81(1,1,1,1)	Details
arginase	81(1,1,1,1)	Details
caspase 3	81(1,1,1,1)	Details
HK1	81(1,1,1,1)	Details
alkaline phosphatase	107(0,3,4,12)	Details
HSP27	75(0,2,4,5)	Details
Paraoxonase	71(0,2,2,11)	Details
superoxide dismutase	94(0,1,10,19)	Details
catalase	83(0,1,8,18)	Details
albumin	50(0,1,1,20)	Details
acid phosphatase	48(0,1,2,13)	Details
beta hexosaminidase	46(0,1,3,6)	Details
transferase	42(0,1,2,7)	Details
glutathione transferase	41(0,1,2,6)	Details
sodium channel (protein family or complex)	40(0,1,2,5)	Details
lactate dehydrogenase (protein family or complex)	37(0,1,1,7)	Details
CYP3A	37(0,1,1,7)	Details
calmodulin	35(0,1,1,5)	Details
cytochrome P450 monooxygenase	35(0,1,1,5)	Details
CYP2D6	33(0,1,1,3)	Details
estrogen receptor alpha	33(0,1,1,3)	Details
CYP1A1	33(0,1,1,3)	Details
CYP2C9	32(0,1,1,2)	Details
phosphodiesterase	32(0,1,1,2)	Details
caspase 8	31(0,1,1,1)	Details
glutamine synthetase	31(0,1,1,1)	Details
tumor necrosis factor	31(0,1,1,1)	Details
CYP2C8	31(0,1,1,1)	Details
HSP60	31(0,1,1,1)	Details
PCNA	31(0,1,1,1)	Details
interferon (protein family or complex)	31(0,1,1,1)	Details
intestinal alkaline phosphatase	31(0,1,1,1)	Details
caspase 9	31(0,1,1,1)	Details
glutaminase	31(0,1,1,1)	Details
BP75	31(0,1,1,1)	Details
CYP2B6	31(0,1,1,1)	Details
ribosomal protein S5	31(0,1,1,1)	Details
muscles	37(0,0,4,17)	Details
epoxide hydrolase	20(0,0,3,5)	Details
glucose 6 phosphate dehydrogenase	19(0,0,2,9)	Details
casein	19(0,0,3,4)	Details
metallothionein (protein family or complex)	18(0,0,3,3)	Details
C18	17(0,0,1,12)	Details
glycogen phosphorylase	16(0,0,2,6)	Details
Ha ras	15(0,0,2,5)	Details
ER1	12(0,0,2,2)	Details
liver carboxylesterase	12(0,0,1,7)	Details
HC5	11(0,0,1,6)	Details
Glutamate pyruvate transaminase	11(0,0,1,6)	Details
RL1	11(0,0,1,6)	Details
A14	10(0,0,1,5)	Details
beta glucuronidase	10(0,0,1,5)	Details
glutamyl transpeptidase	9(0,0,1,4)	Details
cardiac troponin I	9(0,0,0,9)	Details
prothrombin	9(0,0,1,4)	Details
ASAT	8(0,0,1,3)	Details
aryl hydrocarbon hydroxylase	8(0,0,1,3)	Details
glucose 6 phosphatase	8(0,0,1,3)	Details
hexokinase	8(0,0,1,3)	Details
per 1	7(0,0,1,2)	Details
brains	7(0,0,1,2)	Details
phosphoenolpyruvate carboxykinase	7(0,0,1,2)	Details
esterase B3	7(0,0,1,2)	Details
PEPCK	7(0,0,1,2)	Details
protein as	6(0,0,1,1)	Details
cream 1	6(0,0,1,1)	Details
DEF6	6(0,0,1,1)	Details
at protein	6(0,0,1,1)	Details
glutathione S alkyltransferase	6(0,0,1,1)	Details
MCM2	6(0,0,1,1)	Details
Anas	6(0,0,1,1)	Details
corticotropin releasing hormone	6(0,0,1,1)	Details
ppt 1	6(0,0,1,1)	Details
ACh 2	6(0,0,1,1)	Details
and 1 protein	6(0,0,1,1)	Details
follicle stimulating hormone (protein family or complex)	6(0,0,1,1)	Details
DVL1	6(0,0,1,1)	Details
neurotoxic esterase	6(0,0,0,6)	Details
brain 2	6(0,0,1,1)	Details
CF 1 (protein family or complex)	6(0,0,1,1)	Details
myoglobin	6(0,0,0,6)	Details
TP53	6(0,0,1,1)	Details
glucose 6 phosphatases (protein family or complex)	6(0,0,1,1)	Details
progestins (protein family or complex)	6(0,0,1,1)	Details
glycophorin A	6(0,0,1,1)	Details
plasminogen	4(0,0,0,4)	Details
interleukin 2	4(0,0,0,4)	Details
hemoglobin (protein family or complex)	4(0,0,0,4)	Details
ace 1	4(0,0,0,4)	Details

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