Protein Information

Name plasminogen
Synonyms A; Apo(a); APOA2; Plasminogen; APOA 2; Angiostatin; Apolipoprotein A II; Microplasmin…

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
2160188 Rodgers KE, Ellefson DD: Modulation of macrophage protease activity by acute administration of O,O,S trimethyl phosphorothioate. Agents Actions. 1990 Mar;29(3-4):277-85.

Previous studies showed that acute administration of O,O,S trimethyl phosphorothioate (OOS-TMP), a contaminant in malathion, acephate and fenitrothion, led to increases in metabolic activities, such as, secretion of interleukin 1 and nonspecific esterase, of splenic and peritoneal macrophages.
In this report, the effect of OOS-TMP administration on the levels of the neutral proteases, elastase, collagenase and plasminogen activator, in cultures supernatants of peritoneal and splenic macrophages is presented.
3(0,0,0,3) Details
16079077 Gwinn MR, Whipkey DL, Tennant LB, Weston A: Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. Environ Health Perspect. 2005 Aug;113(8):1046-51.

Decreased expression of six RNA species was seen at various time points in all cell strains analyzed: plasminogen activator (PLAT), centromere protein F (CPF), replication factor C (RFC3), thymidylate synthetase (TYMS), a putative mitotic checkpoint kinase (BUB1), and a gene of unknown function (GenBank accession no.
1(0,0,0,1) Details