| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | malathion |
|---|---|
| CAS | diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15177947 | Shaonan L, Xianchuan X, Guonian Z, Yajun T: Kinetic characters and resistance to inhibition of crude and purified brain acetylcholinesterase of three freshwater fishes by organophosphates. Aquat Toxicol. 2004 Jul 14;68(4):293-9. Although the crude enzyme from the trout displayed a different specific activity, kinetic curve, Vmax, and sensitivity to inhibition by oxidized malathion and triazopos compared with the two cyprinoids (i.e. topmouth gudgeon and goldfish), the purified enzymes of all the three species showed no significant difference in all aspects. |
3(0,0,0,3) | Details |
| 2271146 | Tran-Minh C, Pandey PC, Kumaran S: Studies on sensor and its analytical application based on the inhibition of cholinesterase. Biosens Bioelectron. 1990;5(6):461-71. Acetylcholine esterase electrodes, based on glass, Pd/PdO and Ir/IrO2 electrodes as pH sensor, using the immobilized acetylcholine esterase in acrylamide-methacrylamide hydrazides prepolymer are reported and compared. The detection limits for the and ion are found to be 10 (-5) M whereas for paraoxon, methyl parathion and malathion are found to be 10 (-9) M and 10 (-10) M. |
3(0,0,0,3) | Details |
| 6364457 | Sahib IK, Prasada Rao KS, Sambasiva Rao KR, Ramana Rao KV: Sublethal toxicity of malathion on the proteases and free amino acid composition in the liver of the teleost, Tilapia mossambica (Peters). Toxicol Lett. 1984 Jan;20(1):59-62. Exposure of fish to a sublethal concentration of malathion showed a significant inhibition of acetylcholinesterase (AChE) activity. |
81(1,1,1,1) | Details |
| 15333628 | Boutsiouki P, Clough GF: Modulation of microvascular function following low-dose exposure to the organophosphorous compound malathion in human skin in vivo. J Appl Physiol. 2004 Sep;97(3):1091-7. We conclude that short-term exposure to a single low dose of malathion causes prolonged modulation of the physiological function of the cutaneous vasculature and that this is, in part, through its action on acetylcholinesterase at both neuronal and nonneuronal sites. |
81(1,1,1,1) | Details |
| 3564013 | Ketterman AJ, Pond SM, Becker CE: The effects of differential induction of cytochrome P-450, carboxylesterase and glutathione S-transferase activities on malathion toxicity in mice. Toxicol Appl Pharmacol. 1987 Mar 15;87(3):389-92. We produced differential induction of these three enzyme systems in mice with phenobarbital and 2 (3)-tert-butyl-4-hydroxyanisole (BHA) and examined the effects of the induction on the inhibition of acetylcholinesterases by malathion. |
81(1,1,1,1) | Details |
| 15450859 | Damiens G, His E, Gnassia-Barelli M, Quiniou F, Romeo M: Evaluation of biomarkers in oyster larvae in natural and polluted conditions. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jun;138(2):121-8. Malathion induced a decrease in AChE activity and an increase in CAT activity. |
9(0,0,1,4) | Details |
| 2905945 | Habig C, Di Giulio RT, Abou-Donia MB: Comparative properties of channel catfish (Ictalurus punctatus) and blue crab (Callinectes sapidus) acetylcholinesterases. Comp Biochem Physiol C. 1988;91(2):293-300. Crab AChE had a lower Km (9 x 10 (-5) vs 2 x 10 (-4) M) and was more sensitive in terms of KI50S than fish AChE to eserine (2.6 x 10 (-7) vs 3 x 10 (-7) M), malathion (4.5 x 10 (-5) vs 1.6 x 10 (-4) M) and parathion (6.9 x 10 (-5) vs 7 x 10 (-4) M). 4. |
9(0,0,1,4) | Details |
| 10036217 | Jianmongkol S, Marable BR, Berkman CE, Talley TT, Thompson CM, Richardson RJ: Kinetic evidence for different mechanisms of acetylcholinesterase inhibition by (1R)- and (1S)-stereoisomers of isomalathion. Toxicol Appl Pharmacol. 1999 Feb 15;155(1):43-53. |
9(0,0,0,9) | Details |
| 10321902 | Barber D, Correll L, Ehrich M: Comparative effectiveness of organophosphorus protoxicant activating systems in neuroblastoma cells and brain homogenates. J Toxicol Environ Health A. 1999 May 14;57(1):63-74. AChE of hen brain homogenates was also more sensitive than homogenates from other species to malaoxon, the active form of malathion. |
9(0,0,1,4) | Details |
| 1463899 | Hemingway J, Small GJ, Monro A, Sawyer BV, Kasap H: Insecticide resistance gene frequencies in Anopheles sacharovi populations of the Cukurova plain, Adana Province, Turkey. Med Vet Entomol. 1992 Oct;6(4):342-8. In Turkey, the mosquito Anopheles sacharovi has been under field selection pressure sequentially with DDT, dieldrin, malathion and pirimiphosmethyl over a period of 30 years for the purpose of malaria control. In 1984, the field population of An.sacharovi in the malarious Cukurova plain of Adana Province contained an altered acetylcholinesterase-based resistance gene giving broad spectrum resistance against organophosphorus and insecticides. |
3(0,0,0,3) | Details |
| 16289700 | Abdel-Halim KY, Salama AK, El-Khateeb EN, Bakry NM: Organophosphorus pollutants (OPP) in aquatic environment at Damietta Governorate, Egypt: implications for monitoring and biomarker responses. Chemosphere. 2006 Jun;63(9):1491-8. Epub 2005 Nov 14. The obtained results are in parallel to that found in case of cholinesterase activity where the activity of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) was declined at these seasonal period. Chlorpyrifos, chlorpyrifos-methyl, malathion, diazinon, pirimiphos-methyl and profenofos were detected in most samples. |
3(0,0,0,3) | Details |
| 7284405 | Clothier B, Johnson MK, Reiner E: Interaction of some trialkyl phosphorothiolates with acetylcholinesterase. Biochim Biophys Acta. 1981 Aug 13;660(2):306-16. |
3(0,0,0,3) | Details |
| 2364909 | Husain K, Ansari RA: Effectiveness of certain drugs in acute malathion intoxication in rats. Ecotoxicol Environ Saf. 1990 Jun;19(3):271-5. Malathion (500 mg/kg, ip) inhibited acetylcholinesterase (AchE) activity in RBC and brain and produced hyperglycemia and hyperlactacidemia with depletion of in liver, triceps, and brain of animals 2 hr after its administration. |
81(1,1,1,1) | Details |
| 10930655 | Tessier L, Boisvert JL, Vought LB, Lacoursiere JO: Anomalies on capture nets of Hydropsyche slossonae larvae (Trichoptera; Hydropsychidae), a potential indicator of chronic toxicity of malathion (organophosphate insecticide). Aquat Toxicol. 2000 Aug 1;50(1-2):125-139. Both anomalies were highly correlated to the toxic action of malathion, i.e. inhibition of the acetylcholinesterase enzyme (AChE). |
81(1,1,1,1) | Details |
| 2628263 | Pant R, Ramana D: Therapeutic action of in malathion toxicity. Indian J Biochem Biophys. 1989 Aug;26(4):268-72. Administration of malathion to the developing Philosamia ricini larvae induces accumulation of marked inhibition of acetylcholinesterase activity, depletion of all nutrients, heavy weight loss and high mortality. |
81(1,1,1,1) | Details |
| 12755471 | Akhgari M, Abdollahi M, Kebryaeezadeh A, Hosseini R, Sabzevari O: Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats. Hum Exp Toxicol. 2003 Apr;22(4):205-11. The results of the present study suggest the usefulness of RBC AChE measurement as a good biomarker in the estimation of malathion-induced oxidative stress affecting blood and liver. |
8(0,0,1,3) | Details |
| 18472171 | Baffi MA, de Souza GR, de Sousa CS, Ceron CR, Bonetti AM: Esterase enzymes involved in pyrethroid and organophosphate resistance in a Brazilian population of Riphicephallus (Boophilus) microplus (Acari, Ixodidae). Mol Biochem Parasitol. 2008 Jul;160(1):70-3. Epub 2008 Apr 7. EST-1, which was also classified as an AChE, was detected exclusively in tolerant and resistant groups to both acaricides, but displayed greater activity in the malathion-resistant group. |
8(0,0,1,3) | Details |
| 16048685 | Surendran SN, Karunaratne SH, Adams Z, Hemingway J, Hawkes NJ: Molecular and biochemical characterization of a sand fly population from Sri Lanka: evidence for insecticide resistance due to altered esterases and insensitive acetylcholinesterase. Bull Entomol Res. 2005 Aug;95(4):371-80. There was preliminary evidence for elevated esterases and altered acetylcholinesterase in this population, the first report of these resistance mechanisms in sand flies to our knowledge, which probably arose from the malathion-based spraying regimes of the Anti-Malarial Campaign. |
8(0,0,1,3) | Details |
| 10207609 | Worek F, Diepold C, Eyer P: Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics. Arch Toxicol. 1999 Feb;73(1):7-14. Human poisoning by organophosphates bearing two methoxy groups, e.g. by malathion, paraoxon-methyl, dimethoate and oxydemeton-methyl, is generally considered to be rather resistant to oxime therapy. The efficacy of obidoxime in reactivating dimethylphosphoryl-AChE was 40, 9 and 3 times higher than of HI 6, pralidoxime and HLo 7, respectively. |
3(0,0,0,3) | Details |
| 12924923 | Doorn JA, Thompson CM, Christner RB, Richardson RJ: Stereoselective inactivation of Torpedo californica acetylcholinesterase by isomalathion: inhibitory reactions with (1R)- and (1S)-isomers proceed by different mechanisms. Chem Res Toxicol. 2003 Aug;16(8):958-65. |
3(0,0,0,3) | Details |
| 11841371 | Downs AM, Stafford KA, Hunt LP, Ravenscroft JC, Coles GC: Widespread insecticide resistance in head lice to the over-the-counter pediculocides in England, and the emergence of carbaryl resistance. Br J Dermatol. 2002 Jan;146(1):88-93. OBJECTIVES: To establish the extent of insecticide resistance in head lice and acetylcholinesterase activity in the presence of carbaryl in head lice. METHODS: Head lice were collected from school children in four centres across England (Exmouth, Loughborough, Leeds and South Shields), and tested in their response to the insecticides permethrin, phenothrin, malathion and carbaryl. |
3(0,0,0,3) | Details |
| 7713347 | Ehrich M, Jortner BS, Padilla S: Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors. Fundam Appl Toxicol. 1995 Jan;24(1):94-101. Ratios of NTE/AChE inhibition in hen spinal cord, averaged over the doses used, were 2.6 after TOTP, 5.2 after PSP, 1.3 after mipafox, and 0.9 after DFP, which contrast with 0.53 after dichlorvos, 1.0 after malathion, and 0.46 after carbaryl. |
65(0,2,2,5) | Details |
| 18625398 | Magana C, Hernandez-Crespo P, Brun-Barale A, Couso-Ferrer F, Bride JM, Castanera P, Feyereisen R, Ortego F: Mechanisms of resistance to malathion in the medfly Ceratitis capitata. Insect Biochem Mol Biol. 2008 Aug;38(8):756-62. Epub 2008 May 10. Adult flies homozygotes for this mutant allele showed reduced AChE activity and less sensitivity to inhibition by malaoxon, showing that target site insensitivity is one of the factors of malathion resistance. |
63(0,2,2,3) | Details |
| 1909249 | Rogers KR, Cao CJ, Valdes JJ, Eldefrawi AT, Eldefrawi ME: Acetylcholinesterase fiber-optic biosensor for detection of anticholinesterases. Fundam Appl Toxicol. 1991 May;16(4):810-20. Malathion, parathion, and dicrotophos were not detected even at millimolar concentrations; however, longer exposure or prior modification of these compounds (i.e., to malaoxon, paraoxon) may increase the biosensor detection limits. |
7(0,0,0,7) | Details |
| 8481527 | Rodriguez M, Ortiz E, Bisset JA, Hemingway J, Saledo E: Changes in malathion and pyrethroid resistance after cypermethrin selection of Culex quinquefasciatus field populations of Cuba. Med Vet Entomol. 1993 Apr;7(2):117-21. Use of the organophosphorus insecticide malathion for mosquito control in Cuba, for 7 years up to 1986, selected elevated non-specific esterase and altered acetylcholinesterase (AChE) resistance mechanisms in Culex quinquefasciatus. |
7(0,0,1,2) | Details |
| 19152003 | Swain V, Seth RK, Raghavendra K, Mohanty SS: Characterization of biochemical based insecticide resistance mechanism by thermal bioassay and the variation of esterase activity in Culex quinquefasciatus. Parasitol Res. 2009 Jun;104(6):1307-13. Epub 2009 Jan 17. The activity of alpha- and beta-carboxylesterases and acetylcholinesterase of malathion susceptible and resistant strains were compared after thermal treatment. |
7(0,0,1,2) | Details |
| 16343621 | Key PB, Fulton MH: Correlation between 96-h mortality and 24-h acetylcholinesterase inhibition in three grass shrimp larval life stages. Ecotoxicol Environ Saf. 2006 Mar;63(3):389-92. Epub 2005 Dec 15. With regard to mortality, newly hatched larvae and 18-day-old larvae were the most sensitive in the malathion and azinphosmethyl exposures. |
3(0,0,0,3) | Details |
| 8212025 | Keeble VB, Correll L, Ehrich M: Evaluation of knit glove fabrics as barriers to dermal absorption of organophosphorus insecticides using an in vitro test system. Toxicology. 1993 Aug 27;81(3):195-203. Cotton and synthetic knit glove fabrics in combination with an in vitro skin model were used to examine the capability of fabric to decrease the dermal absorption of the organophosphorus insecticides azinphos-methyl, paraoxon, and malathion. Capability for inhibition of acetylcholinesterase was determined in samples of media taken from under the skin barrier after the skin model, with or without fabric protection, had been exposed to the test compounds for 4 h. |
3(0,0,0,3) | Details |
| 20103101 | He P, Davies J, Greenway G, Haswell SJ: Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection. Anal Chim Acta. 2010 Feb 5;659(1-2):9-14. Epub 2009 Dec 3. |
3(0,0,0,3) | Details |
| 15508279 | Timur S, Telefoncu A: Acetylcholinesterase (AChE) electrodes based on gelatin and matrices for the pesticide detection. Artif Cells Blood Substit Immobil Biotechnol. 2004;32(3):427-42. Linear ranges for different organophosphates such as malathion, parathion-methyl, and methamidophos were detected by using both types of biosensor system. |
3(0,0,0,3) | Details |
| 14761699 | Panda S, Sahu SK: Recovery of acetylcholine esterase activity of Drawida willsi (Oligochaeta) following application of three pesticides to soil. Chemosphere. 2004 Apr;55(2):283-90. A sharp decline in the AChE activity of D. willsi was observed up to 9 and 12 days following treatment of carbofuran and malathion in both single and double doses, respectively, whereas very little inhibition was noticed in case of butachlor. |
44(0,1,3,4) | Details |
| 11401758 | Cabello G, Valenzuela M, Vilaxa A, Duran V, Rudolph I, Hrepic N, Calaf G: A rat mammary tumor model induced by the organophosphorous pesticides parathion and malathion, possibly through acetylcholinesterase inhibition. Environ Health Perspect. 2001 May;109(5):471-9. |
39(0,1,2,4) | Details |
| 15036868 | Barata C, Solayan A, Porte C: Role of B-esterases in assessing toxicity of organophosphorus (chlorpyrifos, malathion) and (carbofuran) pesticides to Daphnia magna. Aquat Toxicol. 2004 Feb 10;66(2):125-39. In this study, the cladoceran Daphnia magna was exposed to two model organophosphorous and one pesticides including malathion, chlorpyrifos and carbofuran to assess acetylcholinesterase (AChE) and carboxylesterase (CbE) inhibition and recovery patterns and relate those responses with individual level effects. |
36(0,1,1,6) | Details |
| 1768912 | Bisset JA, Rodriguez MM, Hemingway J, Diaz C, Small GJ, Ortiz E: Malathion and pyrethroid resistance in Culex quinquefasciatus from Cuba: efficacy of pirimiphos-methyl in the presence of at least three resistance mechanisms. Med Vet Entomol. 1991 Apr;5(2):223-8. Use of malathion for mosquito control in Cuba for 7 years up to 1986 has selected for elevated non-specific esterase and altered acetylcholinesterase (AChE) resistance mechanisms in populations of the pest mosquito Culex quinquefasciatus Say. |
6(0,0,1,1) | Details |
| 2519652 | Ffrench-Constant RH, Bonning BC: Rapid microtitre plate test distinguishes insecticide resistant acetylcholinesterase genotypes in the mosquitoes Anopheles albimanus, An. nigerrimus and Culex pipiens. Med Vet Entomol. 1989 Jan;3(1):9-16. |
6(0,0,0,6) | Details |
| 14567574 | Lehtonen KK, Leinio S: Effects of exposure to and malathion on metallothionein levels and acetylcholinesterase activity of the mussel Mytilus edulis and the clam Macoma balthica from the northern Baltic Sea. Bull Environ Contam Toxicol. 2003 Sep;71(3):489-96. |
6(0,0,1,1) | Details |
| 1488701 | Lee HL, Abimbola O, Singh KI: Determination of insecticide susceptibility in Culex quinquefasciatus Say adults by rapid enzyme microassays. Southeast Asian J Trop Med Public Health. 1992 Sep;23(3):458-63. In the insensitive acetylcholinesterase (AChE) test, acetylthiocholine iodide (ACTH) and 5,5-dithiobis-(2-nitrobenzoic acid) (DTNB) were used as substrate and coupling agent respectively. Assay of non-specific esterase however, indicated elevated levels which were correlated with degree of malathion resistance. |
2(0,0,0,2) | Details |
| 18484351 | Tarhoni MH, Lister T, Ray DE, Carter WG: Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers. 2008 Jun;13(4):343-63. As in vitro, dosing of rats with malathion did not result in significant albumin binding in vivo. We have evaluated the potential of plasma albumin to provide a sensitive biomarker of exposure to commonly used organophosphorus pesticides in order to complement the widely used measure of acetylcholinesterase (AChE) inhibition. |
2(0,0,0,2) | Details |
| 17097717 | Bavcon Kralj M, Franko M, Trebse P: Photodegradation of organophosphorus insecticides - investigations of products and their toxicity using gas chromatography-mass spectrometry and AChE-thermal lens spectrometric bioassay. Chemosphere. 2007 Feb;67(1):99-107. Epub 2006 Nov 13. Several other photoproducts including trimethyl esters, which are known to be AChE inhibitors and 1,2,3-benzotriazin-4 (3H)-one as a member of triazine compounds were identified in photodegraded samples of malathion, malaoxon, and azinphos-methyl. |
35(0,1,1,5) | Details |
| 16704049 | Scholz NL, Truelove NK, Labenia JS, Baldwin DH, Collier TK: Dose-additive inhibition of chinook salmon acetylcholinesterase activity by mixtures of organophosphate and insecticides. Environ Toxicol Chem. 2006 May;25(5):1200-7. We extracted AChE from the olfactory nervous system of chinook salmon (Oncorhynchus tshawytscha) and investigated the inhibitory effects of organophosphates (the oxon derivatives of diazinon, chlorpyrifos, and malathion) and carbamates (carbaryl and carbofuran), alone and in two-way combinations. |
34(0,1,1,4) | Details |
| 1595894 | Kumaran S, Tran-Minh C: Determination of organophosphorous and insecticides by flow injection analysis. Anal Biochem. 1992 Jan;200(1):187-94. A flow injection system, incorporating an acetylcholinesterase (AChE) single bead string reactor (SBSR), for the determination of some organophosphorous (azinphos-ethyl, azinphos-methyl, bromophos-methyl, dichlorovos, fenitrothion, malathion, paraoxon, parathion-ethyl and parathion-methyl) and insecticides (carbofuran and carbaryl) is presented. |
6(0,0,1,1) | Details |
| 10771584 | Nigg HN, Knaak JB: Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure. Rev Environ Contam Toxicol. 2000;163:29-111. OPs possessing carboxylesters, such as malathion and isofenphos, are hydrolyzed by the direct action of 'B'-esterases (i.e., carboxylesterase, CaE). The basic biochemical characteristics of RBC AChE and BChE were determined in the 1940s. |
6(0,0,0,6) | Details |
| 12778319 | Bustos-Obregon E, Gonzalez-Hormazabal P: Effect of a single dose of malathion on spermatogenesis in mice. Asian J Androl. 2003 Jun;5(2):105-7. METHODS: The effects of a single dose of malathion [240 mg/kg (1/12 LD (50))] on plasma acetylcholinesterase (ACE) activity, spermatozoa (epididymal cauda counts and teratozoospermia), testis and plasma concentration) were evaluated at day 1, 8, 16, 35 and 40 after treatment. |
6(0,0,1,1) | Details |
| 10887565 | Rodriguez MM, Bisset JA, Mila LH, Calvo E, Diaz C, Alain Soca L: [Levels of insecticide resistance and its mechanisms in a strain of Aedes aegypti of Santiago de Cuba]. Rev Cubana Med Trop. 1999 May-Aug;51(2):83-8. The results of bioassays showed low levels of resistance to fention, malathion and deltametrine, moderate levels of resistance to temephos, metyl-pirimifos and cipermetrine and high levels of resistance to chlorpirifios. In accordance with the high frequency values observed in each of the mechanisms, it was proved that esterases and glutathione-S-transferase were involved in the insecticide resistance but acetylcholinesterases were not. |
2(0,0,0,2) | Details |
| 17324631 | Vioque-Fernandez A, de Almeida EA, Lopez-Barea J: Esterases as pesticide biomarkers in crayfish (Procambarus clarkii, Crustacea): tissue distribution, sensitivity to model compounds and recovery from inactivation. Comp Biochem Physiol C Toxicol Pharmacol. 2007 Apr;145(3):404-12. Epub 2007 Jan 30. Since acetylcholinesterase prevails in nervous tissue and carboxylesterase in digestive gland, they are proposed as biomarkers. Carboxylesterase was inhibited by carbaryl and chlorpyrifos, but not by eserine and malathion. |
2(0,0,0,2) | Details |
| 9626537 | Walker CH: The use of biomarkers to measure the interactive effects of chemicals. Ecotoxicol Environ Saf. 1998 May-Jun;40(1-2):65-70. The interactive effects of mixtures of pesticides in the field are starting to be investigated by this approach (e.g., a recent study of the combined action of malathion and prochloraz in the red-legged partridge). Typically, such assays provide measures of the molecular mechanisms that underlie toxicity (e.g., inhibition of brain acetylcholinesterase activity by organophosphorus insecticides and retardation of the cycle by anticoagulant rodenticides). |
2(0,0,0,2) | Details |
| 18608787 | Krstic DZ, Colovic M, Kralj MB, Franko M, Krinulovic K, Trebse P, Vasic V: Inhibition of AChE by malathion and some structurally similar compounds. J Enzyme Inhib Med Chem. 2008 Aug;23(4):562-73. |
336(3,6,6,6) | Details |
| 16716398 | da Silva AP, Meotti FC, Santos AR, Farina M: Lactational exposure to malathion inhibits brain acetylcholinesterase in mice. Neurotoxicology. 2006 Dec;27(6):1101-5. Epub 2006 Apr 28. |
280(3,4,5,5) | Details |
| 15683842 | Park KH, Kim YS, Chung EY, Choe SN, Choo JJ: Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Dec;139(4):303-8. While other reversible AChE inhibitors such neostigmine and pyridostigmine also depressed the contractility, organophosphate AChE inhibitors malathion, diazinon, or phenthoate did not. |
34(0,1,1,4) | Details |
| 15008520 | Banasik M, Stedeford T, Persad AS, Ueda K, Tanaka S, Muro-Cacho C, Harbison RD: Selective inhibition of acetylcholinesterase in the cerebellum and hippocampus of mice following an acute treatment with malathion. J Enzyme Inhib Med Chem. 2003 Dec;18(6):551-5. |
33(0,1,1,3) | Details |
| 19337507 | Laetz CA, Baldwin DH, Collier TK, Hebert V, Stark JD, Scholz NL: The synergistic toxicity of pesticide mixtures: implications for risk assessment and the conservation of endangered Pacific salmon. Environ Health Perspect. 2009 Mar;117(3):348-53. Epub 2008 Nov 14. METHODS: We measured brain AChE inhibition in juvenile coho salmon (Oncorhynchus kisutch) exposed to sublethal concentrations of the organophosphates diazinon, malathion, and chlorpyrifos, as well as the carbamates carbaryl and carbofuran. |
33(0,1,1,3) | Details |
| 3434778 | Ashour MB, Gee SJ, Hammock BD: Use of a 96-well microplate reader for measuring routine enzyme activities. Anal Biochem. 1987 Nov 1;166(2):353-60. Examples include monitorings of the rate of hydrolysis of acetylthiocholine iodide by eel acetylcholinesterase and the rate of hydrolysis of malathion and nonconventional esters such as O-methyl, O-ethyl, and O-isobutyl carbonates of by commercial porcine liver carboxylesterase. |
6(0,0,1,1) | Details |
| 6490128 | Vaishwanar I, Mallik S: The effect of malathion dust on certain tissues of male rats fed varying levels of dietary protein. Indian J Physiol Pharmacol. 1984 Jan-Mar;28(1):35-41. The effect of malathion, an organophosphorus insecticide on tissue levels of acetylcholinesterase (Ache), phosphomonoesterases and transaminases have been studied in presence of different levels of dietary proteins. |
6(0,0,1,1) | Details |
| 3341039 | Wallace KB, Herzberg U: Reactivation and aging of phosphorylated brain acetylcholinesterase from fish and rodents. Toxicol Appl Pharmacol. 1988 Feb;92(2):307-14. |
6(0,0,0,6) | Details |
| 1498481 | Richmonds CR, Dutta HM: Effect of malathion on the brain acetylcholinesterase activity of bluegill sunfish Lepomis macrochirus. Bull Environ Contam Toxicol. 1992 Sep;49(3):431-5. |
6(0,0,1,1) | Details |
| 11534899 | Belden JB, Lydy MJ: Effects of atrazine on acetylcholinesterase activity in midges (Chironomus tentans) exposed to organophosphorus insecticides. Chemosphere. 2001 Sep;44(8):1685-9. Although similar trends existed for malathion and methyl parathion, differences were not statistically significant. |
2(0,0,0,2) | Details |
| 17698511 | Li H, Schopfer LM, Nachon F, Froment MT, Masson P, Lockridge O: Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry. Toxicol Sci. 2007 Nov;100(1):136-45. Epub 2007 Aug 13. Some organophosphorus compounds are toxic because they inhibit acetylcholinesterase (AChE) by phosphylation of the active site serine, forming a stable conjugate: Ser-O-P (O)-(Y)-(XR) (where X can be O, N, or S and Y can be methyl, OR, or SR). |
2(0,0,0,2) | Details |
| 18341513 | Trevisan R, Uliano-Silva M, Pandolfo P, Franco JL, Brocardo PS, Santos AR, Farina M, Rodrigues AL, Takahashi RN, Dafre AL: Antioxidant and acetylcholinesterase response to repeated malathion exposure in rat cerebral cortex and hippocampus. Basic Clin Pharmacol Toxicol. 2008 Apr;102(4):365-9. Some reports have shown that low doses of malathion, in a repeated treatment regimen, are unable to reduce acetylcholinesterase (AChE) activity in the rat brain, in contrast to the inhibitory effect in acute treatment. |
268(3,3,7,8) | Details |
| 18035420 | da Silva AP, Farina M, Franco JL, Dafre AL, Kassa J, Kuca K: Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex. Neurotoxicology. 2008 Jan;29(1):184-9. Epub 2007 Oct 18. Malathion administration markedly inhibited cortical acetylcholinesterase activity (around 55%) at 3h after malathion challenge and such inhibition was maintained till 24 h after poisoning. |
236(2,4,6,6) | Details |
| 20307142 | Patil VK, David M: Behavioral and morphological endpoints: as an early response to sublethal malathion intoxication in the freshwater fish, Labeo rohita. Drug Chem Toxicol. 2010 Apr;33(2):160-5. This may be a consequence due to inhibition of brain and muscular AChE by malaoxon, via the biotransformation of sequestered malathion. |
33(0,1,1,3) | Details |
| 17143474 | Calaf GM, Parra E, Garrido F: Cell proliferation and tumor formation induced by eserine, an acetylcholinesterase inhibitor, in rat mammary gland. Oncol Rep. 2007 Jan;17(1):25-33. The aim of this study was to examine the effect of eserine, an acetylcholinesterase inhibitor, as are the organophosphorous compounds malathion and parathion, and 17beta on cell proliferation and tumor formation that takes place in the rat mammary gland after in vivo and in vitro treatment. |
32(0,1,1,2) | Details |
| 3814004 | Brown C, Gross WB, Ehrich M: Effects of social stress on the toxicity of malathion in young chickens. Avian Dis. 1986 Oct-Dec;30(4):679-82. They were then challenged orally with a toxic dose of the organophosphate insecticide malathion (250 mg/kg body weight) and evaluated 60 min later for muscarinic signs (diarrhea, lacrimation, respiratory secretions), nicotinic signs (muscle weakness), plasma cholinesterase activity, and brain acetylcholinesterase activity. |
6(0,0,1,1) | Details |
| 11129708 | Karunaratne SH, Hemingway J: Insecticide resistance spectra and resistance mechanisms in populations of Japanese encephalitis vector mosquitoes, Culex tritaeniorhynchus and Cx. gelidus, in Sri Lanka. Med Vet Entomol. 2000 Dec;14(4):430-6. Using wild-caught adult mosquitoes from light traps, log dosage-probit mortality curves for insecticide bioassays were obtained for three insecticides: malathion (organophosphate), propoxur and permethrin (pyrethroid). Propoxur inhibition of acetylcholinesterase (AChE) activity (the target site of organophosphates and carbamates) indicated that in 1998, frequencies of insensitive AChE-based resistance were 9% in Cx. gelidus and 2-23% in Cx. tritaeniorhynchus, whereas in 1984 this resistance mechanism was detected only in 2% of the latter species from Anaradhapura. |
2(0,0,0,2) | Details |
| 17017223 | Cui F, Raymond M, Berthomieu A, Alout H, Weill M, Qiao CL: Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens (Diptera: Culicidae). J Med Entomol. 2006 Sep;43(5):878-83. Bioassays performed with a purified G119S strain indicated that this substitution was associated with high levels of resistance to chlorpyrifos, fenitrothion, malathion, and parathion, but low levels of resistance to dichlorvos, trichlorfon, and fenthion. |
2(0,0,0,2) | Details |
| 18247417 | Aker WG, Hu X, Wang P, Hwang HM: Comparing the relative toxicity of malathion and malaoxon in blue catfish Ictalurus furcatus. Environ Toxicol. 2008 Aug;23(4):548-54. Malathion inhibits the critical body enzyme, acetylcholinesterase (AChE). |
199(2,3,4,4) | Details |
| 18281741 | Krstic D, Colovic M, Krinulovic K, Djuric D, Vasic V: Inhibition of AChE by single and simultaneous exposure to malathion and its degradation products. Gen Physiol Biophys. 2007 Dec;26(4):247-53. |
193(2,3,3,3) | Details |
| 11392132 | Monserrat JM, Yunes JS, Bianchini A: Effects of Anabaena spiroides (Cyanobacteria) aqueous extracts on the acetylcholinesterase activity of aquatic species. Environ Toxicol Chem. 2001 Jun;20(6):1228-35. Inhibition of purified eel AChE using mixtures of bioxidized malathion and aqueous extract of A. spiroides showed a competitive feature (p < 0.05), suggesting that the toxin (s) could be structurally similar to an organophosphorus pesticide and that toxins present in the aqueous extract inhibit the active site of the enzyme. |
166(2,2,2,6) | Details |
| 17450648 | Moss JI: Synergism of toxicity of N,N-diethyl-m-toluamide to German cockroaches (Orthoptera: Blattellidae) by hydrolytic enzyme inhibitors. J Econ Entomol. 1996 Oct;89(5):1151-5. Organophosphate and acetylcholinesterase inhibitors carbaryl, DEF, eserine (physostigmine, malathion and pyridostigmine bromide synergized DEET toxicity also synergized the toxicity of the formamidine pesticides. |
32(0,1,1,2) | Details |
| 15951093 | Senger MR, Rico EP, de Bem Arizi M, Rosemberg DB, Dias RD, Bogo MR, Bonan CD: Carbofuran and malathion inhibit nucleotide hydrolysis in zebrafish (Danio rerio) brain membranes. Toxicology. 2005 Sep 1;212(2-3):107-15. Since and ATP are co-released at the synapse and the acetylcholinesterase inhibition is an important target for pesticide action, here we verified the effect of exposure in vitro and in vivo to carbofuran and malathion on ectonucleotidase activities from brain membranes of zebrafish. |
32(0,1,1,2) | Details |
| 10414779 | Banerjee BD, Seth V, Bhattacharya A, Pasha ST, Chakraborty AK: Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers. Toxicol Lett. 1999 Jun 30;107(1-3):33-47. However, AChE activity and GSH level in lymphocytes of malathion poisoning cases were reduced and GGT activity was enhanced in comparison to control subjects. |
32(0,1,1,2) | Details |
| 9768250 | Diaz C, Bisset JA, Gonzalez T, Rodriguez MM: [Resistance to organophosphate, and pyrethroid insecticides in Blattella germanica (Dictyoptera: Blattellidae) in 2 municipalities of the City of Havana]. Rev Cubana Med Trop. 1994;46(2):130-2. We determined the resistance of 2 Blattella germanica strains collected in 2 municipalities of City of Havana--Playa (P) and Centro Habana (CH)--to six insecticides: malathion, pyrimiphos-methyl, propoxur, cipermetrine, deltametrine, and lambda cialotrine. Gene frequency of increased esterases and of the modified acetylcholinesterase was determined in the 2 strains. |
2(0,0,0,2) | Details |
| 14694590 | Ju Z, Sun J: [The neuromuscular transmission effects induced by pralidoxine on rats with acute isocarbophos poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2002 Dec;20(6):425-6. OBJECTIVE: To study the effects of improving the neuromuscular transmission (NMT), "non-AChE-reactivating effects", by oximes in treating acute isocarbophos poisoning. |
2(0,0,0,2) | Details |
| 8016090 | Mutero A, Pralavorio M, Bride JM, Fournier D: Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5922-6. |
2(0,0,0,2) | Details |
| 2514222 | Bull DL, Wadleigh RW, Patterson RS: Pharmacodynamics of malathion and carbaryl in susceptible and multiresistant German cockroaches (Dictyoptera: Blattellidae). J Econ Entomol. 1989 Dec;82(6):1512-9. Studies with malathion and carbaryl were done to compare toxicity; absorption, metabolism, internal accumulation, and excretion; and in vivo inhibition of acetylcholinesterase (AChE) after topical applications to adult male susceptible (S, Orlando normal) or multiresistant (R, HRDC) German cockroaches, Blattella germanica (L.). |
162(2,2,2,2) | Details |
| 18476213 | Ahmad NW, Huang TS, Balabaskaran S, Lo KM, Das VG: Insecticidal Effects of Organotin (IV) Compounds on Plutella Xylostella (L.) Larvae. Met Based Drugs. 1994;1(1):1-17. The combination of (p-chlorophenyl) diphenyltin N,N-dimethyldithiocarbamate at LD (10) and LD (25) concentrations with sublethal concentrations of Malathion as well as of tricyclohexyltin methanesulphonate at the 0.01% (w/v) concentration with Malathion exerted strong synergistic effects (supplemental synergism) with toxicity index (T.I) values of 7.2, 19.8 and 10.1, respectively.Studies on the in vitro inhibition of acetylcholinesterase prepared from the DBM larvae showed that while most of the triorganotin Compounds tested were without effect on the enzyme, compounds containing the thiocarbamylacetate or the dithiocarbamylacetate moieties demonstrated appreciable levels of inhibition, being comparable in efficacy to commercial grades of Malathion and Methomyl. |
143(1,3,3,3) | Details |
| 9294250 | Scaps P, Demuynck S, Descamps M, Dhainaut A: Effects of organophosphate and pesticides on acetylcholinesterase and choline acetyltransferase activities of the polychaete Nereis diversicolor. Arch Environ Contam Toxicol. 1997 Aug;33(2):203-8. On the other hand, inhibitory effects on acetylcholinesterase (AChE) activity were determined at concentrations of 10 (-6) M for three OP compounds-malathion, parathion-ethyl, and phosalone-and a pesticide-carbaryl. |
32(0,1,1,2) | Details |
| 18260698 | Boone MD: Examining the single and interactive effects of three insecticides on amphibian metamorphosis. Environ Toxicol Chem. 2008 Jul;27(7):1561-8. I exposed tadpoles to single or multiple insecticides at approximately half the reported median lethal concentrations using insecticides that were either acetylcholinesterase inhibitors (carbaryl or malathion) or a sodium-channel disruptor (permethrin). |
31(0,1,1,1) | Details |
| 17974266 | Zhang YL, Mu W, Chen ZL, Han ZR, Ma C, Zhai RH: [Susceptibility and related physiological and biochemical mechanisms of Carposina niponensis Walsingham larvae on six insecticides before and after overwintering]. Ying Yong Sheng Tai Xue Bao. 2007 Aug;18(8):1913-6. The study with impregnating method showed that after overwintering, the susceptibility of Carposina niponensis larvae on triazophos, phoxim, chlorpyrifos, malathion, lambda-cyhalothrin and abamectin was 34.50, 16.71, 3.89, 3.28, 5.90 and 2.73 times as much as that before overwintering, the total protein, and fat contents and carboxylesterase, acid phosphatase, alkaline phosphatase, glutathione-S-transferase, superoxide dismutase, catalase and peroxidase activities in C. niponensis larvae were decreased by 17.10%, 41.76% and 30.08%, 62.36%, 53.47%, 76.19%, 80.60%, 18.77%, 14.16% and 64.02%, respectively, and the activity of acetylcholinesterase, the target enzyme of many insecticides, was 1.41 times as much as that before overwintering. |
31(0,1,1,1) | Details |
| 7481747 | Johnston G: The study of interactive effects of pollutants: a biomarker approach. Sci Total Environ. 1995 Oct 27;171(1-3):205-12. Biochemical biomarkers, such as inhibition of serum butyryl cholinesterase (BuChE) and brain acetyl cholinesterase (AChE), have been useful in studies of interactive effects of pesticides in birds. Studies have shown that hybrid red-legged partridges (Alectoris rufa cross) pretreated with the inducing biosynthesis inhibiting (EBI) fungicide, prochloraz, were more sensitive to the toxic effects of the organophosphorous (OP) insecticide, malathion, than controls. |
2(0,0,0,2) | Details |
| 9768246 | Bisset JA, Rodriguez MM, Dayami L: [Determination of resistance mechanism in Culex quinquefasciatus Say 1823 and its operational implication in the correct use of insecticides for its control]. Rev Cubana Med Trop. 1994;46(2):108-14. Resistance to organophosphorous insecticides such as malathion, chlorpyrihos, and pyrimiphos-methyl; pyrethroids such as deltametrine and lambda cialotrine; and the propoxur was determined in 4 strain of Culex quinquefasciatus of the Eastern, Central and Western parts of Cuba. The increase of esterase enzymes was the main mechanism involved in resistance, followed by altered acetylcholinesterase (AChe). |
2(0,0,0,2) | Details |
| 7726573 | Lai K, Stolowich NJ, Wild JR: Characterization of P-S bond hydrolysis in organophosphorothioate pesticides by organophosphorus hydrolase. Arch Biochem Biophys. 1995 Apr 1;318(1):59-64. The extensive use of organophosphorothioate insecticides in agriculture has resulted in the risk of environmental contamination with a variety of broadly based neurotoxins that inhibit the acetylcholinesterases of many different animal species. |
2(0,0,0,2) | Details |
| 19788278 | Hossain SM, Luckham RE, McFadden MJ, Brennan JD: Reagentless bidirectional lateral flow bioactive paper sensors for detection of pesticides in beverage and food samples. Anal Chem. 2009 Nov 1;81(21):9055-64. A reagentless bioactive paper-based solid-phase biosensor was developed for detection of acetylcholinesterase (AChE) inhibitors, including organophosphate pesticides. The modified sensor is able to detect pesticides without the use of any external reagents with excellent detection limits (bendiocarb approximately 1 nM; carbaryl approximately 10 nM; paraoxon approximately 1 nM; malathion approximately 10 nM) and rapid response times (approximately 5 min). |
2(0,0,0,2) | Details |
| 17364237 | Ahmed M, Rocha JB, Mazzanti CM, Morsch AL, Cargnelutti D, Correa M, Loro V, Morsch VM, Schetinger MR: Malathion, carbofuran and paraquat inhibit Bungarus sindanus (krait) venom acetylcholinesterase and human serum butyrylcholinesterase in vitro. Ecotoxicology. 2007 May;16(4):363-9. Epub 2007 Mar 16. |
119(1,2,3,4) | Details |
| 6701915 | Ansari BA, Kumar K: Malathion toxicity: in vivo inhibition of acetylcholinesterase in the fish Brachydanio rerio (Cyprinidae). Toxicol Lett. 1984 Mar;20(3):283-7. |
118(1,2,3,3) | Details |
| 2380476 | Srikanth NS, Seth PK: Alterations in xenobiotic metabolizing enzymes in brain and liver of rats coexposed to endosulfan and malathion. J Appl Toxicol. 1990 Jun;10(3):157-60. A significant inhibition in brain acetylcholine esterase activity (42%) in the coexposed animals suggests that endosulfan may potentiate the toxicity of malathion by interfering with and carboxylesterase routes of malathion detoxification. |
31(0,1,1,1) | Details |
| 8107298 | Yamanaka S, Yoshida M, Yamamura Y, Nishimura M, Takaesu Y: [A study on acute organophosphorus poisoning--changes in the activity and isoenzyme patterns of serum cholinesterase in human poisoning]. Nippon Eiseigaku Zasshi. 1993 Dec;48(5):955-65. The main bands in the ChE isoenzyme pattern in normal serum were bands 4 and 5 which had the highest activity of acetylcholinesterase (AChE) with a molecular weight of 600,000-800,000, and bands 7, 12, 14, 17 and 18. 2) Inhibition of serum ChE activity was more severe as the amount ingested increased in patients who took Fenitrothion and Malathion. |
31(0,1,1,1) | Details |
| 8023345 | Liu PS, Kao LS, Lin MK: Organophosphates inhibit catecholamine secretion and influx in bovine chromaffin cells. Toxicology. 1994 May 31;90(1-2):81-91. The lethality of organophosphorous compounds has been attributed to their inhibitory effect on acetylcholinesterase (AChE) in the nervous system. Therefore we investigated the toxic effects of methyl parathion and malathion on bovine chromaffin cells. |
2(0,0,0,2) | Details |
| 9813467 | Rodriguez MM, Bisset JA, Mastrapa L, Diaz C: [The association of resistance to organophosphate, and pyrethroid insecticides with the mechanisms of resistance observed in Culex quinquefasciatus strains from Ciudad de La Habana province]. Rev Cubana Med Trop. 1995;47(3):154-60. Increased esterases and altered acetylcholinesterase are still being the major resistance mechanisms in Havana City. Resistance to cholorpirifos was found for the first time in Culex quinquefasciatus, while resistance of malathion and propoxur is maintained, and deterioration to pyrethroid susceptibility is being detected. |
2(0,0,0,2) | Details |
| 12762645 | Cabello G, Juarranz A, Botella LM, Calaf GM: Organophosphorous pesticides in breast cancer progression. J Submicrosc Cytol Pathol. 2003 Jan;35(1):1-9. Parathion and malathion, organophosphorous pesticides are cholinesterase inhibitors responsible for the hydrolysis of body esters, including at cholinergic synapses. Their primary target of action in insects is the nervous system whereby they inhibit the enzyme acetylcholinesterase at synaptic junction. |
2(0,0,0,2) | Details |
| 18755020 | Perera MD, Hemingway J, Karunaratne SP: Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri Lanka. Malar J. 2008 Aug 28;7:168. METHODS: Adult females were exposed to the WHO discriminating dosages of DDT, malathion, fenitrothion, propoxur, lambda-cyhalothrin, cyfluthrin, cypermethrin, deltamethrin, permethrin and etofenprox. The presence of metabolic resistance by esterase, glutathione S-transferase (GST) and monooxygenase-based mechanisms, and the sensitivity of the acetylcholinesterase target site were assessed using synergists, and biochemical, and metabolic techniques. |
2(0,0,0,2) | Details |
| 19253631 | Buyukguzel E: Evidence of oxidative and antioxidative responses by Galleria mellonella larvae to malathion. J Econ Entomol. 2009 Feb;102(1):152-9. I infer that induction of antioxidant defense mechanisms in response to increased oxidative stress may be a result of AChE inhibition by malathion in G. mellonella larvae. |
117(1,1,7,7) | Details |
| 7927563 | Datta C, Gupta J, Sengupta D: Interaction of organophosphorus insecticides phosphamidon & malathion on lipid profile & acetylcholinesterase activity in human erythrocyte membrane. Indian J Med Res. 1994 Aug;100:87-9. The organophosphorus insecticides phosphamidon and malathion were found to inhibit the activity of human acetylcholinesterase in vitro, in the human erythrocyte membrane. |
113(1,2,2,3) | Details |
| 18615705 | Yang ML, Zhang JZ, Zhu KY, Xuan T, Liu XJ, Guo YP, Ma EB: Mechanisms of organophosphate resistance in a field population of oriental migratory locust, Locusta migratoria manilensis (Meyen). Arch Insect Biochem Physiol. 2009 May;71(1):3-15. All these results clearly indicated that the observed malathion resistance in the FR was conferred by multiple mechanisms, including increased detoxification by ESTs and GSTs, and increased activity and reduced sensitivity of AChE to OP inhibition. |
113(1,2,2,3) | Details |
| 15557345 | Buratti FM, D'Aniello A, Volpe MT, Meneguz A, Testai E: Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms. Drug Metab Dispos. 2005 Mar;33(3):295-302. Epub 2004 Nov 22. Malathion desulfuration has been characterized in human liver microsomes (HLMs) with a method based on acetylcholinesterase inhibition that is able to detect nanomolar levels of oxon. |
31(0,1,1,1) | Details |
| 17624398 | Bavcon Kralj M, Cernigoj U, Franko M, Trebse P: Comparison of photocatalysis and photolysis of malathion, isomalathion, malaoxon, and commercial malathion--products and toxicity studies. Water Res. 2007 Nov;41(19):4504-14. Epub 2007 Jun 15. The formation of malaoxon, isomalathion or trimethyl esters correlated well with the induced toxicity (inhibition of acetylcholinesterase), which was observed in photocatalysis of malathion and Radotion, and in photolysis of malaoxon and Radotion. |
31(0,1,1,1) | Details |
| 7459459 | Sahib IK, Rao KV: Correlation between subacute toxicity of malathion and acetylcholinesterase inhibition in the tissues of the teleost Tilapia mossambica. Bull Environ Contam Toxicol. 1980 May;24(5):711-8. |
31(0,1,1,1) | Details |
| 11826520 | Bisset JA, Rodriguez MM, Diaz C, Soca A: [Course of insecticide resistance in Culex quinquefasciatus (Diptera: Culicidae) in a region of La Habana]. Rev Cubana Med Trop. 2000 Sep-Dec;52(3):180-5. The use of malathion to control mosquitoes in Cuba during 7 years until 1986 selected 2 resistance mechanisms: that of elevated activity of nonspecific esterases and that of altered acetylcholinesterase (Ache) in Culex quinquefasciatus (Say). |
6(0,0,1,1) | Details |
| 11286337 | Bachmann TT, Leca B, Vilatte F, Marty JL, Fournier D, Schmid RD: Improved multianalyte detection of organophosphates and carbamates with disposable multielectrode biosensors using recombinant mutants of Drosophila acetylcholinesterase and artificial neural networks. Biosens Bioelectron. 2000 Jun;15(3-4):193-201. |
6(0,0,0,6) | Details |
| 8434460 | Mathews MS, Devi KS: Effect of malathion, -17-beta and on metabolism in prenatal rats and their pups. Vet Hum Toxicol. 1993 Feb;35(1):6-10. Significant inhibition of acetylcholinesterase from malathion exposure was further exaggerated by -17-beta, but was reversed by |
112(1,2,2,2) | Details |
| 8691510 | Li Shao-Non, Fan De-Fang: Correlation between biochemical parameters and susceptibility of freshwater fish to malathion. J Toxicol Environ Health. 1996 Jul;48(4):413-8. The in vitro study also showed that malaoxon instead of malathion was the main inhibitor of AChE. |
112(1,2,2,2) | Details |
| 16050592 | Cook LW, Paradise CJ, Lom B: The pesticide malathion reduces survival and growth in developing zebrafish. Environ Toxicol Chem. 2005 Jul;24(7):1745-50. Malathion's action as an acetylcholinesterase inhibitor and the toxicity of the metabolites of malathion may be responsible for malathion's teratogenic effects on fish development. |
31(0,1,1,1) | Details |
| 2714804 | Chaturvedi AK, Singh G, Rao NG, Parker TM: Toxicological evaluation of a poisoning attributed to ingestion of malathion insect spray and correlation with in vitro inhibition of cholinesterases. Hum Toxicol. 1989 Jan;8(1):11-8. The ability of the blood and bile samples to inhibit, in vitro, rat serum cholinesterase and electric eel acetylcholinesterase was consistent with their malathion concentrations as the bile inhibited both enzymes, while the blood did not. |
31(0,1,1,1) | Details |
| 3234285 | Inbaraj RM, Haider S: Effect of malathion and endosulfan on brain acetylcholinesterase and ovarian steroidogenesis of Channa punctatus (Bloch). Ecotoxicol Environ Saf. 1988 Oct;16(2):123-8. |
6(0,0,1,1) | Details |
| 7234252 | Sadovnikova LD, Anders VN, Sal'nikov VV: [Effect of anticholinesterases on acetylcholinesterase distribution in the human and animal brain (cytochemical study)]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1981;81(2):108-14. |
5(0,0,0,5) | Details |
| 18588939 | Rezg R, Mornagui B, El-Fazaa S, Gharbi N: attenuates malathion induced metabolic disruption in rat liver, involvement of acetylcholinesterase activity. Toxicology. 2008 Aug 19;250(1):27-31. Epub 2008 Jun 5. Indeed, malathion is known to inhibit AChE activity leads to subsequent activation of cholinergic receptor that increased in part, catecholamine and glucocorticoids secretion; provoked glycogenolysis and gluconeogenesis activation. |
94(1,1,3,4) | Details |
| 15596258 | Brocardo PS, Pandolfo P, Takahashi RN, Rodrigues AL, Dafre AL: Antioxidant defenses and lipid peroxidation in the cerebral cortex and hippocampus following acute exposure to malathion and/or zinc Toxicology. 2005 Feb 14;207(2):283-91. Malathion exposure elicited lipid peroxidation and reduced AChE activity in the cerebral cortex and hippocampus. |
88(1,1,2,3) | Details |
| 1981826 | Reddy MS, Jayaprada P, Rao KV: Impact of methylparathion and malathion on cholinergic and non-cholinergic enzyme systems of penaeid prawn, Metapenaeus monoceros. Biochem Int. 1990 Nov;22(4):769-79. The nervous tissue AChE, BUChE and glutaminase activity levels were significantly inhibited, whereas glutamine synthetase activity, and contents were increased significantly following the sublethal exposure of prawn, Metapenaeus, monoceros to methylparathion and malathion. |
31(0,1,1,1) | Details |
| 6807282 | Morton RA, Singh RS: The association between malathion resistance and acetylcholinesterase in Drosophila melanogaster. Biochem Genet. 1982 Feb;20(1-2):179-98. |
29(0,0,4,9) | Details |
| 16782587 | Ramos ZR, Fortunato JJ, Agostinho FR, Martins MR, Correa M, Schetinger MR, Dal-Pizzol F, Quevedo J: Influence of malathion on acetylcholinesterase activity in rats submitted to a forced swimming test. Neurotox Res. 2006 Jun;9(4):285-90. |
14(0,0,2,4) | Details |
| 20035484 | Jebali J, Banni M, Guerbej H, Almeida EA, Bannaoui A, Boussetta H: Effects of malathion and cadmium on acetylcholinesterase activity and metallothionein levels in the fish Seriola dumerilli. Fish Physiol Biochem. 2006 Mar;32(1):93-8. |
14(0,0,2,4) | Details |
| 10686320 | Lund SA, Fulton MH, Key PB: The sensitivity of grass shrimp, Palaemonetes pugio, embryos to organophosphate pesticide induced acetylcholinesterase inhibition. Aquat Toxicol. 2000 Mar 1;48(2-3):127-134. Embryos were exposed for 24 h to either chlorpyrifos or malathion. |
5(0,0,0,5) | Details |
| 16824333 | Liu L, Xie GY, Wang J, Sun JX: [Experimental study on protective effects of HupA in the treatment of isocarbophos poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Jun;24(6):323-5. OBJECTIVE: To investigate the therapeutic and prophylactic efficiency of HupA in mice with acute isocarbophos poisoning, and the protective effects of the HupA on AChE inhibited by isocarbophos. |
5(0,0,0,5) | Details |
| 3564042 | Johnson JA, Wallace KB: Species-related differences in the inhibition of brain acetylcholinesterase by paraoxon and malaoxon. Toxicol Appl Pharmacol. 1987 Apr;88(2):234-41. In contrast, fish are more sensitive to malathion and malaoxon. |
5(0,0,0,5) | Details |
| 8292752 | Berkman CE, Quinn DA, Thompson CM: Interaction of acetylcholinesterase with the enantiomers of malaoxon and isomalathion. Chem Res Toxicol. 1993 Sep-Oct;6(5):724-30. |
5(0,0,0,5) | Details |
| 11123973 | Doorn JA, Gage DA, Schall M, Talley TT, Thompson CM, Richardson RJ: Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds with loss of thiomethyl: kinetic and mass spectral evidence for an unexpected primary leaving group. Chem Res Toxicol. 2000 Dec;13(12):1313-20. |
5(0,0,0,5) | Details |
| 8212012 | Ward TR, Ferris DJ, Tilson HA, Mundy WR: Correlation of the anticholinesterase activity of a series of organophosphates with their ability to compete with agonist binding to muscarinic receptors. Toxicol Appl Pharmacol. 1993 Oct;122(2):300-7. Some compounds that inhibit acetylcholinesterase (AChE) activity compete directly with quinuclidinyl benzilate (QNB) binding, a muscarinic antagonist which binds to all subtypes equally, and with cis-methyldioxolane (CD), an agonist that binds with high affinity to the M2 subtype of muscarinic receptors. Echothiophate and DFP were potent inhibitors of [3H] CD binding, as were the active "oxon" forms of parathion, malathion, and disulfoton. |
5(0,0,0,5) | Details |
| 9315286 | Kamal MA: Effect of malathion on kinetic parameters of acetylcholinesterase (EC 3.1.1.7) in vitro. Biochem Mol Biol Int. 1997 Sep;43(1):89-97. Kinetic analysis of the interaction of malathion with camel erythrocyte acetylcholinesterase was investigated in the present study. |
87(1,1,2,2) | Details |
| 17849895 | Wu H, Yang M, Guo Y, Xie Z, Ma E: Comparisons of malathion susceptibility, target sensitivity, and detoxification enzyme activity in nine field populations of Oxya chinensis (Orthoptera: Acrididae). J Econ Entomol. 2007 Aug;100(4):1409-15. It seemed that the observed malathion resistance in the JN population was attributed to at least two resistance mechanisms, including increased EST activity (2.2-fold) and reduced sensitivity of AChE to inhibition by malaoxon (4.6-fold) compared with those of the XY population. |
87(1,1,2,2) | Details |
| 15180375 | Printes LB, Callaghan A: A comparative study on the relationship between acetylcholinesterase activity and acute toxicity in Daphnia magna exposed to anticholinesterase insecticides. Environ Toxicol Chem. 2004 May;23(5):1241-7. Acetylcholinesterase (AChE) activity was measured in Daphnia magna that had been exposed to four organophosphates (OPs; parathion, chlorpyrifos, malathion, and acephate) and one (propoxur) for 48 h. |
13(0,0,1,8) | Details |
| 1421479 | Brogdon WG, Beach RF, Barber AM, Cordon-Rosales C: A generalized approach to detection of organophosphate resistance in mosquitoes. Med Vet Entomol. 1992 Apr;6(2):110-4. With susceptible mosquitoes, the LT100 values determined from bioassays corresponded closely with times taken to abolish the activity of acetylcholinesterase activity in biochemical assays: approximately 2 h for malathion and 3 h for fenitrothion. |
13(0,0,2,3) | Details |
| 1509669 | Prakash N, Narayana K, Murthy GS, Moudgal NR, Honnegowda: The effect of malathion, an organophosphate, on the plasma FSH, 17 and concentrations and acetylcholinesterase activity and conception in dairy cattle. Vet Hum Toxicol. 1992 Apr;34(2):116-9. |
12(0,0,2,2) | Details |
| 11453726 | Doorn JA, Talley TT, Thompson CM, Richardson RJ: Probing the active sites of butyrylcholinesterase and cholesterol esterase with isomalathion: conserved stereoselective inactivation of serine hydrolases structurally related to acetylcholinesterase. Chem Res Toxicol. 2001 Jul;14(7):807-13. |
5(0,0,0,5) | Details |
| 1629220 | Fournier D, Bride JM, Hoffmann F, Karch F: Acetylcholinesterase. J Biol Chem. 1992 Jul 15;267(20):14270-4. |
5(0,0,0,5) | Details |
| 11137467 | Monserrat JM, Bianchini A: Methodological and biological aspects to be considered in acetylcholinesterase reactivation assays using 2-PAM. Environ Toxicol Pharmacol. 2000 Dec;9(1-2):39-47. Enzyme inhibition induced by 2-PAM showed to mask subtle inhibition due to malathion, suggesting that a previous characterization of 2-PAM inhibition must be done before its use in reactivation assays. |
4(0,0,0,4) | Details |
| 9585096 | Mortensen SR, Hooper MJ, Padilla S: Rat brain acetylcholinesterase activity: developmental profile and maturational sensitivity to and organophosphorus inhibitors. Toxicology. 1998 Jan 16;125(1):13-9. |
4(0,0,0,4) | Details |
| 19429256 | Franco JL, Posser T, Mattos JJ, Trevisan R, Brocardo PS, Rodrigues AL, Leal RB, Farina M, Marques MR, Bainy AC, Dafre AL: reverses malathion-induced impairment in antioxidant defenses. Toxicol Lett. 2009 Jun 22;187(3):137-43. Epub 2009 Mar 4. Malathion toxicity has been related to the inhibition of acetylcholinesterase and induction of oxidative stress, while zinc has been shown to possess neuroprotective effects in experimental and clinical studies. |
87(1,1,2,2) | Details |
| 8806851 | Jianmongkol S, Berkman CE, Thompson CM, Richardson RJ: Relative potencies of the four stereoisomers of isomalathion for inhibition of hen brain acetylcholinesterase and neurotoxic esterase in vitro. Toxicol Appl Pharmacol. 1996 Aug;139(2):342-8. The cholinergic toxicity of malathion is exacerbated by its isomerization product, isomalathion, which inhibits detoxifying carboxylesterases as well as target acetylcholinesterase (AChE). |
86(1,1,1,6) | Details |
| 18617161 | Jun D, Musilova L, Kuca K, Kassa J, Bajgar J: Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. Chem Biol Interact. 2008 Sep 25;175(1-3):421-4. Epub 2008 May 7. Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). |
86(1,1,1,6) | Details |
| 8335887 | Abou Zeid MM, el-Barouty G, Abdel-Reheim E, Blancato J, Dary C, el-Sebae AH, Saleh MA: Malathion disposition in dermally and orally treated rats and its impact on the blood serum acetylcholine esterase and protein profile. J Environ Sci Health B. 1993 Aug;28(4):413-30. |
12(0,0,2,2) | Details |
| 14713564 | Abdel-Rahman A, Dechkovskaia AM, Goldstein LB, Bullman SH, Khan W, El-Masry EM, Abou-Donia MB: Neurological deficits induced by malathion, DEET, and permethrin, alone or in combination in adult rats. J Toxicol Environ Health A. 2004 Feb 27;67(4):331-56. Treatment with DEET or permethrin alone, malathion and permethrin, or DEET and permethrin produced significant increases in cortical acetylcholinesterase (AChE) activity. |
12(0,0,2,2) | Details |
| 15612566 | Taskin V, Kence M: The genetic basis of malathion resistance in housefly (Musca domestica L.) strains from Turkey. Genetika. 2004 Nov;40(11):1475-82. In addition, we checked the malathion carboxylesterase (MCE), percent remaining activities in acetylcholinesterase (AChE), -S-transferase (GST), and general esterase activities in all 5 strains used in this study. |
12(0,0,2,2) | Details |
| 8448346 | Berkman CE, Ryu S, Quinn DA, Thompson CM: Kinetics of the postinhibitory reactions of acetylcholinesterase poisoned by chiral isomalathion: a surprising nonreactivation induced by the RP stereoisomers. Chem Res Toxicol. 1993 Jan-Feb;6(1):28-32. |
4(0,0,0,4) | Details |
| 19130375 | Somerset V, Baker P, Iwuoha E: Mercaptobenzothiazole-on-gold organic phase biosensor systems: 1. J Environ Sci Health B. 2009 Feb;44(2):164-78. This paper reports the construction of the gold/mercaptobenzothiazole/polyaniline/acetylcholinesterase/polyvinylaceta te (Au/ MBT/PANI/AChE/PVAc) thick-film biosensor for the determination of certain organophosphate pesticide solutions in selected aqueous organic solvent solutions. The biosensor was then applied to detect a series of 5 organophosphorous pesticides in aqueous organic solvents and the pesticides studied were parathion-methyl, malathion and chlorpyrifos. |
4(0,0,0,4) | Details |
| 12696436 | Bozsik A, Francis F, Gaspar C, Haubruge E: Effect of some insecticides on acetylcholinesterase from beneficial insects: Coccinella septempunctata, Chrysoperla carnea and Forficula auricularia. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2002;67(3):671-7. |
4(0,0,0,4) | Details |
| 12018585 | Mourya DT, Gokhale MD, Barde PV, Deobagkar DN: Highly-substrate active isoenzyme acetylcholinesterase-II, in rosy eye mutant of Aedes aegypti mosquito. Indian J Exp Biol. 2001 Aug;39(8):807-10. Both the strains were equally susceptible to DDT, malathion and deltamethrin. |
4(0,0,0,4) | Details |
| 17590326 | Du D, Huang X, Cai J, Zhang A: Comparison of pesticide sensitivity by electrochemical test based on acetylcholinesterase biosensor. Biosens Bioelectron. 2007 Sep 30;23(2):285-9. Epub 2007 May 18. Four pesticides of carbaryl, malathion, dimethoate and monocrotophos were selected to discuss their inhibition efficiencies to AChE. |
85(1,1,1,5) | Details |
| 18371787 | Du D, Ding J, Cai J, Zhang J, Liu L: In situ electrodeposited nanoparticles for facilitating electron transfer across self-assembled monolayers in biosensor design. Talanta. 2008 Feb 15;74(5):1337-43. Epub 2007 Sep 14. Under the optimal experimental conditions, the inhibition of malathion on AChE biosensor was proportional to its concentration in two ranges, from 0.001 to 0.1 microg mL (-1) and from 0.1 to 25 microg mL (-1), with detection limit of 0.001 microg mL (-1). |
82(1,1,1,2) | Details |
| 16002478 | Rider CV, LeBlanc GA: An integrated addition and interaction model for assessing toxicity of chemical mixtures. Toxicol Sci. 2005 Oct;87(2):520-8. Epub 2005 Jul 7. A ternary mixture of acetylcholinesterase inhibiting organophosphates (malathion and parathion) and the P450 inhibitor piperonyl butoxide was used to model toxicity. |
81(1,1,1,1) | Details |
| 1554246 | Venturino A, Gauna LE, Bergoc RM, Pechen de D'Angelo AM: Effect of exogenously applied polyamines on malathion toxicity in the toad Bufo arenarum Hensel. Arch Environ Contam Toxicol. 1992 Jan;22(1):135-9. increased the degree of inhibition of acetylcholinesterase activity elicited by malathion, and impaired the recovery of this activity at the end of the treatment. |
81(1,1,1,1) | Details |
| 8913110 | Bourguet D, Capela R, Raymond M: An insensitive acetylcholinesterase in Culex pipiens (Diptera:Culicidae) from Portugal. J Econ Entomol. 1996 Oct;89(5):1060-6. Resistance mechanisms of a strain (PRAIAS) of northern house mosquito, Culex pipiens L., collected in Portugal in 1993, and highly resistant to organophosphates and carbamates, were investigated by comparing the resistance characteristics to 3 organophosphorous (temephos, chlorpyrifos, malathion) and 1 (propoxur) insecticides in the presence or absence of synergists; and by determining the possible occurrence of overproduced esterases or insensitive acetylcholinesterase (AChE). |
11(0,0,1,6) | Details |
| 2417385 | Cohen SD, Williams RA, Killinger JM, Freudenthal RI: Comparative sensitivity of bovine and rodent acetylcholinesterase to in vitro inhibition by organophosphate insecticides. Toxicol Appl Pharmacol. 1985 Dec;81(3 Pt 1):452-9. |
11(0,0,0,11) | Details |
| 19444631 | Beltran KS, Pocsidio GN: Acetylcholinesterase activity in Corbicula fluminea Mull., as a biomarker of organophosphate pesticide pollution in Pinacanauan River, Philippines. Environ Monit Assess. 2009 May 12. In vitro experiments on the total soft tissue, adductor muscles, digestive glands, and gills were conducted to assess the degree of localization of AChE as well as the sensitivity and tolerance of the enzymes in these tissues to varying concentrations of malathion. |
9(0,0,1,4) | Details |
| 10632139 | Akgur SA, Ozturk P, Sozmen EY, Delen Y, Tanyalcin T, Ege B: Paraoxonase and acetylcholinesterase activities in humans exposed to organophosphorous compounds. J Toxicol Environ Health A. 1999 Dec 24;58(8):469-74. Both serum cholinesterase and PON1 activities were measured spectrophotometrically from 18 male agricultural workers who were chronically exposed to azinphos methyl, chlorpyriphos, or malathion and other pesticides during cereal spraying, transportation, and storage. |
3(0,0,0,3) | Details |
| 14679985 | Key PB, Fulton MH, Harman-Fetcho JA, McConnell LL: Acetylcholinesterase activity in grass shrimp and aqueous pesticide levels from South Florida drainage canals. Arch Environ Contam Toxicol. 2003 Oct;45(3):371-7. Three organophosphate insecticides (chlorpyrifos, malathion, diazinon) were detected at three sites in two canals (Military and North). |
3(0,0,0,3) | Details |
| 17328951 | Dutta K, Bhattacharyay D, Mukherjee A, Setford SJ, Turner AP, Sarkar P: Detection of pesticide by polymeric enzyme electrodes. Ecotoxicol Environ Saf. 2008 Mar;69(3):556-61. Epub 2007 Feb 27. Screen-printed electrodes (SPEs) containing immobilized acetylcholine esterase (AChE) enzyme were used for the electrochemical determination of organophosphorous (OP) and pesticides. Responses were observed for the pesticides Monocrotophos, Malathion, Metasystox and Lannate over the concentration range 0-10 ppb (microg L (-1)). |
3(0,0,0,3) | Details |
| 7572467 | Mourya DT, Hemingway J, Leake CJ: Post-inoculation changes in enzyme activity of Aedes aegypti infected with Chikungunya virus. Acta Virol. 1995 Feb;39(1):31-5. Levels of acetylcholinesterase, non-specific esterases, glutathione-S-transferase and glucose-6-phosphate dehydrogenase in Aedes aegypti (L.) mosquitoes inoculated intrathoracally with Chikungunya virus were elevated, as compared to uninoculated control insects. Malathion bioassays indicated a reduction in the susceptibility of experimentally injected insects with virus or virus-free inoculum, compared to non-inoculated controls. |
1(0,0,0,1) | Details |
| 19303125 | Ramphul U, Boase T, Bass C, Okedi LM, Donnelly MJ, Muller P: Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda. Trans R Soc Trop Med Hyg. 2009 Nov;103(11):1121-6. Epub 2009 Mar 19. Anopheles gambiae s.l. adults were raised from wild-caught larvae sampled from two ecologically distinct breeding sites and exposed to WHO discriminating concentrations of DDT, permethrin, deltamethrin, bendiocarb and malathion. Using molecular diagnostics, susceptible and resistant specimens were further tested for the presence of knockdown resistance (kdr) and acetylcholinesterase 1 resistance (ace-1 (R)) alleles. |
1(0,0,0,1) | Details |
| 1900004 | Caballero de Castro AC, Rosenbaum EA, Pechen de D'Angelo AM: Effect of malathion on Bufo arenarum Hensel development--I. Biochem Pharmacol. 1991 Feb 15;41(4):491-5. Continuous exposure depressed acetylcholinesterase (EC 3.1.1.7), butyrylcholinesterase (EC 3.1.1.8) and carboxylesterase (EC 3.1.1.1) activities. |
1(0,0,0,1) | Details |
| 11425027 | Lee SE, Lees EM: Biochemical mechanisms of resistance in strains of Oryzaephilus surinamensis (Coleoptera: Silvanidae) resistant to malathion and chlorpyrifos-methyl. J Econ Entomol. 2001 Jun;94(3):706-13. The acetylcholinesterase, carboxylesterase, and cytochrome P450 monooxygenase activities of three strains of Oryzaephilus srinamensis (L.) were examined to better understand biochemical mechanisms of resistance. |
1(0,0,0,1) | Details |
| 19429114 | Acker CI, Luchese C, Prigol M, Nogueira CW: Antidepressant-like effect of diphenyl diselenide on rats exposed to malathion: involvement of Na+K+ ATPase activity. Neurosci Lett. 2009 May 22;455(3):168-72. Epub 2009 Mar 27. The role of Na+K+ ATPase, acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities and oxidative stress in antidepressant behavior were investigated in cerebral cortex of rats. |
1(0,0,0,1) | Details |
| 8723267 | Wirth MC, Georghiou GP: Organophosphate resistance in Culex pipiens from Cyprus. J Am Mosq Control Assoc. 1996 Mar;12(1):112-8. All population samples generally revealed organophosphate resistance to malathion, temephos, chlorpyrifos, fenthion, dichlorvos, and pirimiphos methyl, in decreasing order of magnitude. Resistance was associated with the presence of 5 different overproduced esterases (esterases A1, A2, A5, B2, and B5) as well as an insensitive form of acetylcholinesterase. |
1(0,0,0,1) | Details |
| 9685989 | Rodriguez MM, Bisset J, Rodriguez I, Diaz C: [Determination of insecticide resistance and its biochemical mechanisms in 2 strains of Culex quinquefasciatus from Santiago de Cuba]. Rev Cubana Med Trop. 1997;49(3):209-14. It was analyzed the behavior of the resistance of 3 organophosphated insecticides (malathion, clorpirifos and methyl-pyrimifos), 3 pyrethroids (deltamethrin, lambda-cyhalothrin and cypermethrin), and 1 (propuxur) in populations of Culex quinquefasciatus from 2 municipalities of the province of Santiago de Cuba. It was determined by the biochemical tests that there existed a high frequency of the mechanisms of esterases and altered acetylcholinesterase. |
1(0,0,0,1) | Details |
| 9174953 | Tran-Minh C: Biosensors in flow-injection systems for biomedical analysis, process and environmental monitoring. J Mol Recognit. 1996 Sep-Dec;9(5-6):658-63. Acetylcholinesterase sensors have been used in batch systems for the determination of pesticides, but they require large amounts of substrate. |
1(0,0,0,1) | Details |
| 9768235 | Alvarez Montes de Oca DM, Ortiz Losada E, Bisset Lazcano JA, Rodriguez Coto MM: [Mechanisms of resistance to organophosphate insecticides, carbamates, and pyrethroids in populations of Musca domestica L. (Diptera: Muscidae)]. Rev Cubana Med Trop. 1994;46(1):51-4. Resistance to organophosphorus insecticides (malathion, chlorpyriphos, pyrimiphos-methyl); carbamates (propoxur); and pyrethroids (permethrin, deltametrine, cypermetrine, and lambda cialotrine) was studied in field populations of Musca domestica; results were compared with a susceptible reference strain. Biochemical microplate tests were also carried out to determine the presence of esterase and acetylcholinesterase enzymes in the three populations. |
1(0,0,0,1) | Details |
| 16619611 | Casimiro S, Coleman M, Hemingway J, Sharp B: Insecticide resistance in Anopheles arabiensis and Anopheles gambiae from Mozambique. J Med Entomol. 2006 Mar;43(2):276-82. Increased frequencies of insecticide insensitive acetylcholinesterase, the target site for carbamates and organophosphates, were found in 16 of the populations tested. An. gambiae s.s. from all localities remained fully susceptible to DDT and the organophosphorus insecticide malathion. |
1(0,0,0,1) | Details |
| 11962304 | Yao H, Jiang C, Ye G, Cheng J: [Insecticide resistance of different populations of white-backed planthopper, Sogatella furcifera (Horvath) (Homoptera:Delphacidae)]. Ying Yong Sheng Tai Xue Bao. 2002 Jan;13(1):101-5. The specific activities of some resistance-associated enzymes, i.e. esterase, carboxylesterase, glutathione S-transferase and acetylcholinesterase from these populations were also measured. The resistant levels to malathion, methamidophos, isoprocarb and buprofezin were markedly higher in Yunnan and Hainan populations than in other populations, but considerably more heterogeneity in response to insecticides was found in Zhejiang and Guangxi populations. |
1(0,0,0,1) | Details |
| 10421486 | Vasilic Z, Stengl B, Drevenkar V: Dimethylphosphorus metabolites in serum and urine of persons poisoned by malathion or thiometon. Chem Biol Interact. 1999 May 14;119-120:479-87. |
0(0,0,0,0) | Details |
| 17067049 | Zayed AB, Szumlas DE, Hanafi HA, Fryauff DJ, Mostafa AA, Allam KM, Brogdon WG: Use of bioassay and microplate assay to detect and measure insecticide resistance in field populations of Culex pipiens from filariasis endemic areas of Egypt. J Am Mosq Control Assoc. 2006 Sep;22(3):473-82. Microplate assays were performed to measure levels of beta esterase, acetylcholinesterase, insensitive acetylcholinesterase, oxidases, and glutathione-S-transferase enzymes. The Qalubiya larval population was susceptible only to malathion, whereas Sharkiya larvae were susceptible to malathion, temephos, and chlorpyrifos. |
1(0,0,0,1) | Details |
| 17110060 | Buratti FM, Leoni C, Testai E: Foetal and adult human CYP3A isoforms in the bioactivation of organophosphorothionate insecticides. Toxicol Lett. 2006 Dec 15;167(3):245-55. Epub 2006 Oct 24. Since OPT-induced neurodevelopmental effects may be due to in situ bioactivation by foetal enzymes, the catalytic activity of the foetal CYP3A7 toward chlorpyrifos (CPF), parathion (PAR), malathion (MAL) and fenthion (FEN) has been assessed by using recombinant enzymes. |
0(0,0,0,0) | Details |
| 2437688 | Dikshith TS, Srivastava MK, Raizada RB, Kumar SN: Interaction of hexachlorocyclohexane and malathion in male guinea pigs after repeated dermal application. Vet Hum Toxicol. 1987 Apr;29(2):138-43. |
0(0,0,0,0) | Details |
| 17327255 | Brocardo PS, Assini F, Franco JL, Pandolfo P, Muller YM, Takahashi RN, Dafre AL, Rodrigues AL: attenuates malathion-induced depressant-like behavior and confers neuroprotection in the rat brain. Toxicol Sci. 2007 May;97(1):140-8. Epub 2007 Feb 27. |
0(0,0,0,0) | Details |
| 10887566 | Bisset JA, Rodriguez MM, Diaz C, Alain Soca L: [Characterization of resistance to organophosphate insecticides, carbamates, and pyrethroids in Culex quinquefasciatus from the State of Miranda, Venezuela]. Rev Cubana Med Trop. 1999 May-Aug;51(2):89-94. Resistance of Culex quinquefasciatus from Miranda, Venezuela to the organophosphate insecticides malathion and chlorpirifos was higher than 30x whereas resistance to pyrethroids metylpirimifos, fention, cipametrine, deltametrine, permetrine and lambdacyalotrine and to organochlorate DDT was lower than 4x. Biochemical tests revealed a very low frequency of the altered acetylcholinesterase mechanism (0.13). |
1(0,0,0,1) | Details |
| 11107890 | Diaz C, Perez M, Rodriguez MM, Calvo E, Bisset JA, Fresneda M: [Resistance to insecticides in Blattella germanica species strains from Santiago de Cuba]. Rev Cubana Med Trop. 2000 Jan-Apr;52(1):24-30. A study was conducted on the level of resistance to seven insecticides, namely, 3 organophosphate compounds (malathion, chlorpyrifos and pirimiphos-methyl), one (propoxur) and 1 pyrethroid (cypermethrin, deltamethrin and lambdacialotrine) of three field-collected strains of Blattella germanica (Linnaeus, 1767) from Santiago de Cuba. |
0(0,0,0,0) | Details |
| 19038063 | Munhenga G, Masendu HT, Brooke BD, Hunt RH, Koekemoer LK: Pyrethroid resistance in the major malaria vector Anopheles arabiensis from Gwave, a malaria-endemic area in Zimbabwe. Malar J. 2008 Nov 28;7:247. METHODS: Standard WHO bioassays, using 0.75% permethrin, 4% DDT, 5% malathion, 0.1% bendiocarb and 4% dieldrin were performed on wild-collected adult anopheline mosquitoes and F1 progeny of An. arabiensis reared from wild-caught females. Biochemical assays were used to determine the relative levels of detoxifying enzyme systems including non-specific esterases, monooxygenases and glutathione-S-transferases as well as to detect the presence of an altered acetylcholine esterase (AChE). |
1(0,0,0,1) | Details |
| 19024933 | Patil VK, David M: Behavioral and respiratory dysfunction in the freshwater fish, Labeo rohita (Hamilton) under malathion intoxication. J Basic Clin Physiol Pharmacol. 2008;19(2):167-75. Carp in toxic media exhibited irregular, erratic, and darting swimming movements, hyperexcitability, and loss of equilibrium and sinking to the bottom, which might be due to the inactivation of acetylcholine esterase activity, resulting in excess accumulation of in cholinergic synapses leading to hyperstimulation. |
1(0,0,0,1) | Details |
| 15120779 | Benslama A, Moutaouakkil S, Charra B, Menebhi L: [The intermediate syndrome during organophosphorus pesticide poisoning] . Ann Fr Anesth Reanim. 2004 Apr;23(4):353-6. We report two cases of malathion poisoning complicated by intermediate syndrome. |
0(0,0,0,0) | Details |
| 14658508 | Perez-Mendoza J, Fabrick JA, Zhu KY, Baker JE: Alterations in esterases are associated with malathion resistance in Habrobracon hebetor (Hymenoptera: Braconidae). J Econ Entomol. 2000 Feb;93(1):31-7. |
0(0,0,0,0) | Details |
| 11834209 | John S, Kale M, Rathore N, Bhatnagar D: Protective effect of in dimethoate and malathion induced oxidative stress in rat erythrocytes. J Nutr Biochem. 2001 Sep;12(9):500-504. |
0(0,0,0,0) | Details |
| 8551300 | Mazzarri MB, Georghiou GP: Characterization of resistance to organophosphate, and pyrethroid insecticides in field populations of Aedes aegypti from Venezuela. J Am Mosq Control Assoc. 1995 Sep;11(3):315-22. Resistance to the organophosphates (OP) temephos, malathion, and pirimiphos methyl, and the propoxur was found to be low (< 5-fold) in 3 Aedes aegypti populations collected from Falcon and Aragua states of Venezuela. |
0(0,0,0,0) | Details |
| 11714250 | Samimi A, Last JA: Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon. Toxicol Appl Pharmacol. 2001 Nov 1;176(3):181-6. A computer search of a protein structure database showed an unexpected region of partial homology between the active site sequence of acetylcholinesterase and a segment of lysyl hydroxylase, suggesting a possible molecular basis for these observations. |
1(0,0,0,1) | Details |
| 12505439 | Hazarika A, Sarkar SN, Hajare S, Kataria M, Malik JK: Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study. Toxicology. 2003 Mar 14;185(1-2):1-8. Toxicity of organophosphates stems mainly from the accumulation of due to inhibition of acetylcholinesterase (AChE). |
1(0,0,0,1) | Details |
| 6783365 | Maunder JW: Novel phenomena arising from the use of acetylcholinesterase inhibiting insecticides against human head lice. Community Med. 1981 Feb;3(1):31-7. |
1(0,0,0,1) | Details |
| 11750089 | Johnson VJ, Rosenberg AM, Lee K, Blakley BR: Increased T-lymphocyte dependent antibody production in female SJL/J mice following exposure to commercial grade malathion. Toxicology. 2002 Jan 15;170(1-2):119-29. |
0(0,0,0,0) | Details |
| 1703470 | Picollo de Villar MI, Fontan A, Wood E, Zerba E: The biochemical basis of tolerance to malathion in Rhodnius prolixus. Comp Biochem Physiol C. 1990;96(2):361-5. Acetylcholinesterase from R. prolixus heads was 3.3-fold less sensitive to inhibition by malaoxon than the similar enzyme of T. infestans. 4. |
1(0,0,0,1) | Details |
| 17824663 | Walz I, Schwack W: Cutinase inhibition by means of insecticidal organophosphates and carbamates. 3. J Agric Food Chem. 2007 Oct 3;55(20):8177-86. Epub 2007 Sep 8. This type of enzymatic oxidation is easier to perform and more efficient, as compared to or N-bromosuccinimide, used for acetylcholine esterase (AChE) assay in water analyses, but is insufficient for complex matrices such as plant sample extracts. Upon CPO oxidation, chlorpyrifos-methyl showed a very strong cutinase inhibition as compared to the corresponding oxon standard, and oxidized malathion, contrarily to malaoxon, revealed cutinase inhibition, which however obeyed a reversible reaction mechanism in contrast to the usually irreversible reactions of organophosphates. |
1(0,0,0,1) | Details |
| 431841 | Pettinati L, Perrelli G: [Pesticides in rural pathology] . Minerva Med. 1979 Mar 10;70(12):867-72. The latter group contains the very commonly employed alkylthiophosphates (malathion, parathion, etc.). These are well-known inhibitors of acetylcholine esterase and thus responsible for harm to the nervous system. |
1(0,0,0,1) | Details |
| 16619610 | Casimiro S, Coleman M, Mohloai P, Hemingway J, Sharp B: Insecticide resistance in Anopheles funestus (Diptera: Culicidae) from Mozambique. J Med Entomol. 2006 Mar;43(2):267-75. Low levels of insecticide-insensitive acetylcholinesterase, the target site for carbamates and organophosphates, were found in all populations tested. An. funestus from all localities remained fully susceptible to DDT and the organophosphorus insecticide malathion. |
1(0,0,0,1) | Details |
| 12505448 | Masoud L, Vijayasarathy C, Fernandez-Cabezudo M, Petroianu G, Saleh AM: Effect of malathion on apoptosis of murine L929 fibroblasts: a possible mechanism for toxicity in low dose exposure. Toxicology. 2003 Mar 14;185(1-2):89-102. While acute organophosphorous compound poisoning due to inhibition of acetylcholinesterase is a well-established clinical entity, the existence of chronic poisoning due to exposure to low levels of organophosphorous compounds (below the threshold required for cholinergic clinical symptoms) is a hotly debated issue. |
1(0,0,0,1) | Details |
| 15478171 | van der Schalie WH, Shedd TR, Widder MW, Brennan LM: Response characteristics of an aquatic biomonitor used for rapid toxicity detection. J Appl Toxicol. 2004 Sep-Oct;24(5):387-94. In the laboratory studies, the aquatic biomonitor responded to the majority of chemicals at the 96-h lc (50) within an hour or less, although substantially higher response times were found for malathion and pentachlorophenol. Although data are limited, the aquatic biomonitor appears to respond more rapidly to chemicals causing membrane irritation, narcosis or polar narcosis than to acetylcholinesterase inhibitors or oxidative phosphorylation uncouplers. |
1(0,0,0,1) | Details |
| 20132373 | Schofield DA, Dinovo AA: Generation of a mutagenized organophosphorus hydrolase for the biodegradation of the organophosphate pesticides malathion and demeton-S. J Appl Microbiol. 2010 Jan 11. Activity was associated with organophosphate detoxification as the hydrolysed substrate lost the ability to inhibit acetylcholinesterase. |
1(0,0,0,1) | Details |
| 8846108 | Ward TR, Mundy WR: Organophosphorus compounds preferentially affect second messenger systems coupled to M2/M4 receptors in rat frontal cortex. Brain Res Bull. 1996;39(1):49-55. Recent reports indicate that organophosphate insecticides, in addition to inhibiting acetylcholinesterase activity, can bind directly at a subset of muscarinic receptors, which also bind cis-methyldioxolane with high affinity. We have investigated the action of the active forms of parathion, malathion, and chlorpyrifos (paraoxon, malaoxon, and chlorpyrifos oxon, respectively) on these second messenger systems in cortical slices from adult male Long-Evans rats. |
1(0,0,0,1) | Details |
| 17303541 | Rezg R, Mornagui B, Kamoun A, El-Fazaa S, Gharbi N: Effect of subchronic exposure to malathion on metabolic parameters in the rat. C R Biol. 2007 Feb;330(2):143-7. Epub 2006 Dec 8. At the end of the experiment, acetylcholinesterase activity (AChE), haematocrit value, haemoglobin content, and blood concentration were estimated. |
1(0,0,0,1) | Details |
| 18240518 | Rodriguez MM, Bisset JA, Fernandez D: Levels of insecticide resistance and resistance mechanisms in Aedes aegypti from some Latin American countries. J Am Mosq Control Assoc. 2007 Dec;23(4):420-9. Biochemical tests showed high frequencies of esterase and glutathione-S-transferase activity; however, the frequency of altered acetylcholinesterase mechanism was low. Eight Latin American strains of Aedes aegypti were evaluated for resistance to 6 organophosphates (temephos, malathion, fenthion, pirimiphos-methyl, fenitrothion, and chlorpirifos) and 4 pyrethroids (deltamethrin, lambdacyhalothrin, betacypermethrin, and cyfluthrin) under laboratory conditions. |
1(0,0,0,1) | Details |
| 6525997 | Awad OM: Molecular mechanism for the inhibition of acetylcholinesterase enzyme by organophosphorothionates. Enzyme. 1984;32(4):193-200. The different mechanisms, whereby EPN and malathion inhibit the action of cholinesterase on are described. |
1(0,0,0,1) | Details |
| 19655174 | Fonseca-Gonzalez I, Cardenas R, Quinones ML, McAllister J, Brogdon WG: Pyrethroid and organophosphates resistance in Anopheles (N.) nuneztovari Gabaldon populations from malaria endemic areas in Colombia. Parasitol Res. 2009 Oct;105(5):1399-409. Epub 2009 Aug 5. Insecticides evaluated included the pyrethroids lambda-cyhalothrin and deltamethrin, organophosphates malathion and fenitrothion, and the organochlorine dichlorodiphenyltrichloroethane (DDT). Evidence is presented for low-level initial selection of some resistance mechanisms such as mixed-function oxidases and modified acetylcholinesterase. |
1(0,0,0,1) | Details |
| 20064834 | Balbuena P, Li W, Magnin-Bissel G, Meldrum JB, Ehrich M: Comparison of two blood-brain barrier in vitro systems: cytotoxicity and transfer assessments of malathion/oxon and lead Toxicol Sci. 2010 Apr;114(2):260-71. Epub 2010 Jan 11. Passage of organophosphate compounds was determined utilizing inhibition of acetylcholinesterase enzyme in a neuroblastoma cell line (SH-SY5Y) localized below the barrier system. |
1(0,0,0,1) | Details |
| 17513201 | Valvassori SS, Fortunato JJ, Gomes KM, Reus GZ, Martins MR, Gavioli EC, Schetinger MR, Dal-Pizzol F, Quevedo J: Acute and subacute exposure to malathion impairs aversive but not non-associative memory in rats. Neurotox Res. 2007 Jul;12(1):71-9. This pesticide affects the central nervous system by inhibiting acetylcholinesterase, leading to an increase of in the synaptic cleft, and subsequent activation of cholinergic muscarinic and nicotinic receptors. |
1(0,0,0,1) | Details |
| 11681666 | Maklakov A, Ishaaya I, Freidberg A, Yawetz A, Horowitz AR, Yarom I: Toxicological studies of organophosphate and pyrethroid insecticides for controlling the fruit fly Dacus ciliatus (Diptera: Tephritidae). J Econ Entomol. 2001 Oct;94(5):1059-66. This was supported by the insignificant decrease of head acetylcholinesterase activity. |
1(0,0,0,1) | Details |
| 16257396 | Aluigi MG, Angelini C, Falugi C, Fossa R, Genever P, Gallus L, Layer PG, Prestipino G, Rakonczay Z, Sgro M, Thielecke H, Trombino S: Interaction between organophosphate compounds and cholinergic functions during development. Chem Biol Interact. 2005 Dec 15;157-158:305-16. Epub 2005 Oct 28. The biological function of the ChE enzymes is well known and has been studied since the beginning of the XXth century; in particular, acetylcholinesterase (AChE, E.C. 3.1.1.7) is an enzyme playing a key role in the modulation of neuromuscular impulse transmission. The chosen organophosphates were the ones mainly used in Europe: diazinon, chlorpyriphos, malathion, and phentoate, all of them belonging to the thionophosphate chemical class. |
1(0,0,0,1) | Details |
| 9216867 | Kallander DB, Fisher SW, Lydy MJ: Recovery following pulsed exposure to organophosphorus and insecticides in the midge, Chironomus riparius. Arch Environ Contam Toxicol. 1997 Jul;33(1):29-33. The importance of recovery following pulsed and continuous exposure was determined by measuring the acute toxicity of two organophosphorus (parathion and malathion) and four (aldicarb, carbaryl, carbofuran and propoxur) insecticides. Acetylcholinesterase activity in midges given two 1-h pulses of carbaryl separated by 24 h in clean water showed reactivation to control levels between the two exposures. |
1(0,0,0,1) | Details |
| 9322308 | Lee HL, Tien WD, Omar B: Insecticide resistance status and mechanisms in Malaysian Blattella germanica (Linnaeus). Southeast Asian J Trop Med Public Health. 1997 Mar;28(1):212-7. The insecticide resistance status of 4 strains of adult male Blattella germanica, viz M (Malacca), E (England), F (restaurant) and K (cafeteria) against malathion and bendiocarb compared with a reference susceptible strain (S) was determined by using a modified WHO bioassay method. The biochemical microplate enzyme assays technique employed indicated that the resistance in M and E strains were attributed to acetylcholinesterase insensitivity. |
1(0,0,0,1) | Details |
| 18380172 | David M, Shivakumar HB, Ramesh H, Marigoudar SR, Naik VR: Hepatotoxic potential of Malathion in the freshwater teleost, Cirrhinus mrigala (Hamilton). J Basic Clin Physiol Pharmacol. 2007;18(4):307-14. An increase in free amino acids, protease activity, and (Ach) levels, in contrast to decrement in total, structural, and soluble proteins, and acetylcholine esterase (AchE) activity were observed at 5 and 15 days of exposure, but on day 25 of exposure, all values reached near normalcy. |
1(0,0,0,1) | Details |
| 16042503 | Lotti M, Moretto A: Organophosphate-induced delayed polyneuropathy. . Toxicol Rev. 2005;24(1):37-49. The ratio of inhibitory powers for acetylcholinesterase and NTE represents the crucial guideline for the aetiological attribution of OP-induced peripheral neuropathy. We also discuss case reports where neuropathies were not convincingly attributed to fenthion, malathion, omethoate/dimethoate, parathion and merphos. |
1(0,0,0,1) | Details |
| 19561983 | Scharf JE, Johnson GT, Harbison SC, McCluskey JD, Harbison RD: Dermal absorption of a dilute aqueous solution of malathion. . J Emerg Trauma Shock. 2008 Jul;1(2):70-3. Analyzing these results through the Hazard Index model for recreational swimmer and bather exposure levels typically measured in contaminated swimming pools and surface waters after bait application indicated that these exposures are an order of magnitude less than a minimal dose known to result in a measurable change in acetylcholinesterase activity. |
1(0,0,0,1) | Details |
| 19399848 | Moore PD, Yedjou CG, Tchounwou PB: Malathion-induced oxidative stress, cytotoxicity, and genotoxicity in human liver carcinoma (HepG (2)) cells. Environ Toxicol. 2009 Apr 27. Its toxicity has been associated with the inhibition of acetylcholinesterase activity, leading to the interference with the transmission of nerve impulse, accumulation of at synaptic junctions, and subsequent induction of adverse health effects including headache, dizziness, nausea, vomiting, bradycardia, and miosis. |
1(0,0,0,1) | Details |
| 15550276 | Bonfanti P, Colombo A, Orsi F, Nizzetto I, Andrioletti M, Bacchetta R, Mantecca P, Fascio U, Vailati G, Vismara C: Comparative teratogenicity of chlorpyrifos and malathion on Xenopus laevis development. Aquat Toxicol. 2004 Dec 10;70(3):189-200. We speculate that this muscular damage was related to inhibition of acetylcholinesterase that showed a clear concentration-response in CPF and MTN exposed larvae. |
1(0,0,0,1) | Details |
| 12297085 | Martinez-Tabche L, Galar MM, Olvera HE, Chehue RA, Lopez Lopez E, Gomez-Olivan L, Terron Sierra O: Toxic effect and bioavailability of malathion spiked in natural sediments from the Ignacio Ramirez Dam on the snail Stagnicola sp. Ecotoxicol Environ Saf. 2002 Jul;52(3):232-7. The toxic effect of MA on the snail Stagnicola sp was evaluated by biochemical tests of acetylcholinesterase (AchE) activity, protein concentration, lipid peroxidation level (LPL), and lipid content; a toxicokinetic study was also carried out. |
1(0,0,0,1) | Details |
| 11522282 | Seth V, Banerjee BD, Bhattacharya A, Pasha ST, Chakravorty AK: Pesticide induced alterations in acetylcholine esterase and gamma glutamyl transpeptidase activities and level in lymphocytes of human poisoning cases. Clin Biochem. 2001 Jul;34(5):427-9. |
1(0,0,0,1) | Details |
| 8435483 | Mourya DT, Hemingway J, Leake CJ: Changes in enzyme titres with age in four geographical strains of Aedes aegypti and their association with insecticide resistance. Med Vet Entomol. 1993 Jan;7(1):11-6. The enzymes acetylcholinesterase, glutathione S-transferase (GST), glucose 6-phosphate dehydrogenase (G6PD), and general esterases were assayed in four strains of Aedes aegypti mosquitoes aged between 1 and 30 days. Insecticide bioassays showed that two strains (Trinidad and Virtudes) of Ae. aegypti were resistant to DDT, deltamethrin and malathion, whereas two other strains (Bangkok and Indian) were susceptible to all four classes of insecticides tested. |
1(0,0,0,1) | Details |
| 3569712 | Takahashi H, Tanaka J, Tsuda S, Shirasu Y: Contribution of monoaminergic nervous system in potentiation of 2-sec-butylphenyl N-methylcarbamate (BPMC) toxicity by malathion in male mice. Fundam Appl Toxicol. 1987 Apr;8(3):415-22. When the inhibitory effect of each N-methylcarbamate on brain acetylcholinesterase (AChE) was compared with its LD50, among five N-methylcarbamates BPMC had particularly strong anti-AChE activity. |
1(0,0,0,1) | Details |
| 15081274 | Vidair CA: Age dependence of organophosphate and neurotoxicity in the postnatal rat: extrapolation to the human. Toxicol Appl Pharmacol. 2004 Apr 15;196(2):287-302. Because these compounds probably exert their effects through the inhibition of acetylcholinesterase (AChE), the above question can be narrowed to whether the cholinesterase inhibition and neurotoxicity they produce is age-dependent, both in terms of the effects produced and potency. Four pesticides were tested in rat pups in their third postnatal week: aldicarb, chlorpyrifos, malathion, and methamidophos. |
1(0,0,0,1) | Details |
| 16813231 | Luk'ianov AS, Semina TK, Korolev AM: [Forecasting parameters of acute chemical toxicity according to in vitro conformation changes of proteins]. Med Tr Prom Ekol. 2006;(5):33-40. The authors analyze experimental data on in vitro effects induced by chemicals that were used throughout MEIC toxicologic studies in ovalbumin and acetylcholinesterase of human RBC. |
1(0,0,0,1) | Details |
| 10029921 | Bracco JE, Barata JM, Marinotti O: Evaluation of insecticide resistance and biochemical mechanisms in a population of Culex quinquefasciatus (Diptera: Culicidae) from Sao Paulo, Brazil. Mem Inst Oswaldo Cruz. 1999 Jan-Feb;94(1):115-20. The PIN95 strain showed low levels of resistance to organophosphates [malathion (3.3-fold), fenitrothion (11.2-fold)] and a [propoxur (3.0-fold)]. An alteration in the sensitivity of acetylcholinesterase to insecticide inhibition was also found in the PIN95 mosquitoes. |
1(0,0,0,1) | Details |
| 9511154 | Prozorovskii VB, Skopichev VG, Ardab'eba TV, Panov PB: [Erythrocyte structural changes as a possible reason for the low effectiveness of specific therapy for carbophos poisoning]. Morfologiia. 1997;112(6):60-4. Following up to 76% acetylcholinesterase inhibition with distinct symptoms of intoxication nearly 30% of erythrocytes were deformed and tended to aggregate. |
1(0,0,0,1) | Details |
| 10774652 | Karunaratne SH: Insecticide cross-resistance spectra and underlying resistance mechanisms of Sri Lankan anopheline vectors of malaria. Southeast Asian J Trop Med Public Health. 1999 Sep;30(3):460-9. Adult mosquitos were individually tested for their insecticide detoxifying enzyme activities and altered target-site, acetylcholinesterase. Adult and larval bioassays were carried out to obtain log-probit mortality lines for malathion, propoxur, permethrin and chlorpyrifos. |
1(0,0,0,1) | Details |
| 224645 | Sterri SH, Rognerud B, Fiskum SE, Lyngaas S: Effect of toxogonin and P2S on the toxicity of carbamates and organophosphorus compounds. Acta Pharmacol Toxicol. 1979 Jul;45(1):9-15. Toxogonin (80 mg/kg intraperitoneally) given 15 min. prior to the administration of organophosphorus insecticides dimethoate, malathion, parathion and azinphos-methyl, organophosphorus warfare agents soman and tabun, or carbamates physostigmine, pyridostigmine and aldicarb, reduced the toxicity in mice of these agents by increasing their LD50 dose 1.5-3 fold. The acetylcholinesterase activity in erythrocytes, cerebrum and diaphragm of surviving mice 20 hours after organophosphate intoxication was similar both in toxogonin and P2S treated animals and untreated animals. |
1(0,0,0,1) | Details |
| 12583695 | Bentur Y, Raikhlin-Eisenkraft B, Singer P: Beneficial late administration of obidoxime in malathion poisoning. Vet Hum Toxicol. 2003 Feb;45(1):33-5. Early treatment of organophosphate (OP) poisoning with oximes results in reactivation of acetylcholinesterase and patient recovery. |
1(0,0,0,1) | Details |
| 1355942 | Kolesnichenko IP, Dolgo-Saburova IS, Somova TV: [Changes in the biochemical composition of the cerebrospinal fluid in acute carbophos poisoning]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1992;92(2):95-9. As far as the pathogenesis of poisonings with organophosphorus pesticides is concerned, in addition to irreversible inhibition of acetylcholinesterase (AGE) in tissues, of importance are changes in the other systems which essentially determine the outcome of intoxication. The purpose of the present study was to examine the nature of changes occurring in total protein and protein fractions, free amino acids (aspartic and glutamic acids, and in certain enzymes (AST, ALT, CP, GGTP, GDH) in the cerebrospinal fluid (CSF) of patients with acute Malathion insecticide poisoning. 137 patients aged 20 to 50 years were placed under observation. |
1(0,0,0,1) | Details |
| 19274371 | Fonseca-Gonzalez I, Quinones ML, McAllister J, Brogdon WG: Mixed-function oxidases and esterases associated with cross-resistance between DDT and lambda-cyhalothrin in Anopheles darlingi Root 1926 populations from Colombia. Mem Inst Oswaldo Cruz. 2009 Feb;104(1):18-26. All field populations were susceptible to deltamethrin, permethrin, malathion and fenitrothion. Enzyme levels related to insecticide resistance, including mixed function oxidases (MFO), non-specific esterases (NSE), glutathione S-transferases and modified acetylcholinesterase were evaluated in all populations and compared with a susceptible natural strain. |
1(0,0,0,1) | Details |
| 7228208 | Siddiqui MK, Seth TD, Saxena MC: Acetylcholinesterase activity in red blood cells of healthy, diseased and exposed persons. Indian J Med Sci. 1980 Dec;34(12):289-92. |
1(0,0,0,1) | Details |