| 14694590 |
Ju Z, Sun J: [The neuromuscular transmission effects induced by pralidoxine chloride on rats with acute isocarbophos poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2002 Dec;20(6):425-6.
OBJECTIVE: To study the effects of improving the neuromuscular transmission (NMT), "non-AChE-reactivating effects", by oximes in treating acute isocarbophos poisoning. METHODS: The effect of pralidoxime chloride (PAM-Cl) on the neuromuscular transmission (NMT) in rats exposed to isocarbophos was studied by using the stimulation single fiber electromyography (SSFEMG) to determine the single fiber action potential. RESULTS: After the rats exposed to isocarbophos were treated by PAM-Cl, the mean consecutive difference (MCD) value [(25.99 +/- 5.84) microsecond] of single fiber action potential was significantly lower than that before PAM-Cl treatment [(33.21 +/- 4.09) microsecond, (P < 0.01)], but no AChE reactivation in blood and gastrocnemius was observed. CONCLUSION: PAM-Cl has "non-AChE-reactivating effects", it could markedly improve isocarbophos-induced NMT block of gastrocnemius. |
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