Protein Information

Name glutathione transferase
Synonyms GST class mu 2; GST 4; GST4; GSTM; GSTM 2; GSTM2; GSTM2 2; GSTmu3…

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
3530629 Wood E, Casabe N, Melgar F, Zerba E: Distribution and properties of glutathione S-transferase from T. infestans. Comp Biochem Physiol B. 1986;84(4):607-17.

The glutathione transferase from T. infestans is able to render aqueous metabolites when incubated in vitro with malathion, parathion and fenitrothion.
31(0,1,1,1) Details
8548864 Pedrajas JR, Peinado J, Lopez-Barea J: Oxidative stress in fish exposed to model xenobiotics. Chem Biol Interact. 1995 Dec 22;98(3):267-82.

The levels of soluble thiobarbituric acid reactive substances (TBARS) increased markedly in animals treated with polar xenobiotics, CuCl2 or paraquat; exposure to the apolar xenobiotics, dieldrin or malathion, enhanced significantly the microsomal TBARS while decreasing the microsomal glutathione transferase activity.
6(0,0,1,1) Details
18691867 Kapoli P, Axarli IA, Platis D, Fragoulaki M, Paine M, Hemingway J, Vontas J, Labrou NE: Engineering sensitive glutathione transferase for the detection of xenobiotics. Biosens Bioelectron. 2008 Nov 15;24(3):498-503. Epub 2008 Jul 4.

The mutant Gln53Ala of GST I Exhibits 9.2-fold higher inhibition potency for the insecticide malathion, compared to the wild-type enzyme.
2(0,0,0,2) Details
15849910 Magdalena Rodriguez M, Bisset JA, Fernandez D, Omayda P: [Resistance to insecticides in larvae and adults of Aedes aegypti, Havana City: prevalence of A4 esterasa associated with resistance to temephos]. Rev Cubana Med Trop. 2004 Jan-Apr;56(1):54-60.

The results of the bioassays in larvae showed a complete susceptibility to organophosphate insecticides, malathion, clorpirifos, methyl-pyrimifos and propoxur carbamate in both people's councils.
It was proved that he amplified activity of these enzymes was at an elevated frequency in both people's councils, the same as the glutathione transferase (GST) in one of the 2 people's councils.
1(0,0,0,1) Details
7138493 Wool D, Noiman S, Manheim O, Cohen E: Malathion resistance in Tribolium strains and their hybrids: inheritance patterns and possible enzymatic mechanisms (Coleoptera, Tenebrionidae). Biochem Genet. 1982 Aug;20(7-8):621-36.

The model which best explains the genetic results, particularly the difference between the reciprocal crosses, assumes a modifier resistance allele on the Y chromosome. (3) The levels of activity of total esterases, carboxylesterases, mixed-function oxidases, epoxide hydrase, and glutathione transferase in the parent strains and their hybrids were measured quantitatively.
1(0,0,0,1) Details