| Name | Paraoxonase |
|---|---|
| Synonyms | A esterase 1; Aromatic esterase 1; Arylesterase; ESA; Esterase A; K 45; PON; PON 1… |
| Name | malathion |
|---|---|
| CAS | diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10632139 | Akgur SA, Ozturk P, Sozmen EY, Delen Y, Tanyalcin T, Ege B: Paraoxonase and acetylcholinesterase activities in humans exposed to organophosphorous compounds. J Toxicol Environ Health A. 1999 Dec 24;58(8):469-74. Both serum cholinesterase and PON1 activities were measured spectrophotometrically from 18 male agricultural workers who were chronically exposed to azinphos methyl, chlorpyriphos, or malathion and other pesticides during cereal spraying, transportation, and storage. |
36(0,1,1,6) | Details |
| 15228952 | Abdollahi M, Donyavi M, Pournourmohammadi S, Saadat M: Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase in rats following subchronic exposure to malathion. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Apr;137(4):343-7. The possible mechanisms including increased energy production to detoxification, depressed paraoxonase activity, and increased production of cyclic nucleotides are discussed. |
1(0,0,0,1) | Details |
| 10602389 | Sams C, Mason HJ: Detoxification of organophosphates by A-esterases in human serum. Hum Exp Toxicol. 1999 Nov;18(11):653-8. Specific A-esterase activity to each OP substrate was measured in the serum of 100 individuals using established spectrophotometric methods for paraoxonase and chlorpyrifos-oxonase and a novel assay for malaoxonase activity. 3. |
1(0,0,0,1) | Details |
| 6540280 | Balasubramanian MP, Dhandayuthapani S, Nellaiappan K, Ramalingam K: A comparative study on esterases from three species of Raillietina. J Helminthol. 1984 Jun;58(2):101-5. Based on the inhibitory effect of inhibitors p-CMB, EDTA, malathion, silver and eserine sulphate, the various esterases have been classified into arylesterase, carboxylesterase, acetylesterase and cholinesterase. |
31(0,1,1,1) | Details |
| 17406008 | Engel SM, Berkowitz GS, Barr DB, Teitelbaum SL, Siskind J, Meisel SJ, Wetmur JG, Wolff MS: Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am J Epidemiol. 2007 Jun 15;165(12):1397-404. Epub 2007 Apr 3. Maternal urine samples were analyzed for six dialkylphosphate metabolites and malathion dicarboxylic acid. Likewise, higher levels of total diethylphosphates and total dialkylphosphates were associated with an increase in abnormal reflexes, as was total dimethylphosphates after paraoxonase expression was considered. |
1(0,0,0,1) | Details |
| 6298443 | Dauterman WC: The role of hydrolases in insecticide metabolism and the toxicological significance of the metabolites. J Toxicol Clin Toxicol. 1982 Aug;19(6-7):623-35. The phosphorotriester hydrolases (arylesterases and DFP-ases) catalyze the P-anhydride bond cleavage of the "leaving group", a major route of detoxication of organophosphates. Carboxylesterases hydrolyze the carboethoxy group of malathion and also have hydrolytic activity toward certain synthetic pyrethroids. |
1(0,0,0,1) | Details |