Protein Information

Name glucose 6 phosphate dehydrogenase
Synonyms 6 phosphogluconolactonase; GDH; G6PDH; Glucose 6 phosphate dehydrogenase; GDH/6PGL endoplasmic bifunctional protein; GDH/6PGL endoplasmic bifunctional protein precursor; Glucose 1 dehydrogenase; Glucose dehydrogenase…

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
3234285 Inbaraj RM, Haider S: Effect of malathion and endosulfan on brain acetylcholinesterase and ovarian steroidogenesis of Channa punctatus (Bloch). Ecotoxicol Environ Saf. 1988 Oct;16(2):123-8.

Brain acetylcholinesterase (AchE) and ovarian delta 5,3 beta-hydroxysteroid dehydrogenase (delta 5,3 beta-HSD) and glucose-6-phosphate dehydrogenase (G-6-PD) activities were studied.
1(0,0,0,1) Details
3861690 Haider S, Upadhyaya N: Effect of commercial formulation of four organophosphorus insecticides on the ovaries of a freshwater teleost, Mystus vittatus (bloch)--a histological and histochemical study. J Environ Sci Health B. 1985 Jun;20(3):321-40.

The chronic effect of an exposure to a sublethal concentration of commercial formulation of 4 organophosphorus insecticides such as birlane (chlorfenvinphos), gardona (tetrachlorvinphos), phosdrin (mevinphos) and malathion on midvitellogenic ovaries of Mystus vittatus was investigated using several histological and histochemical techniques.
Reduced glucose-6-phosphate dehydrogenase activity was also observed.
1(0,0,0,1) Details
7504364 Prabhakaran S, Shameem F, Devi KS: Influence of protein deficiency on hexachlorocyclohexane and malathion toxicity in pregnant rats. Vet Hum Toxicol. 1993 Oct;35(5):429-33.

Depletion in glutathione (GSH) and decreased activities of GSH peroxidase, GSH reductase and glucose-6-phosphate dehydrogenase were observed from the protein deficiency and pesticide exposure.
1(0,0,0,1) Details
2095780 Matin MA, Sattar S, Husain K: Modification of malathion induced neurochemical changes by adrenalectomy in rats. Mol Chem Neuropathol. 1990 Aug-Oct;13(1-2):119-28.

0(0,0,0,0) Details
15596258 Brocardo PS, Pandolfo P, Takahashi RN, Rodrigues AL, Dafre AL: Antioxidant defenses and lipid peroxidation in the cerebral cortex and hippocampus following acute exposure to malathion and/or zinc chloride. Toxicology. 2005 Feb 14;207(2):283-91.

This study investigates the effects of acute exposure to organophosphate insecticide malathion (250 mg/kg, i.p.) and/or ZnCl2 (5 mg/kg, i.p.), with the following parameters: lipid peroxidation and the activity of acetylcholinesterase (AChE), glutathione reductase (GR), glutathione S-transferase (GST), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PDH), and the levels of total glutathione (GSH-t) in the hippocampus and cerebral cortex of female rats.
13(0,0,2,3) Details
15446413 Myshkin VA, Guliaeva IA, Ibatullina RB, Savlukov AI, Enikeev DA, Sergeeva SA: [The influence of the actoprotectors on lipid peroxidation and erythrocyte membranes in rats poisoned with malathion ]. Patol Fiziol Eksp Ter. 2004 Jul-Sep;(3):10-2.

The addition of bemitil and tietasol normalized electric charge and osmotic resistance in red cell membranes, activity of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase and content of lipid peroxidation products--ketodienes and TBA-reacting products.
1(0,0,0,1) Details
8435483 Mourya DT, Hemingway J, Leake CJ: Changes in enzyme titres with age in four geographical strains of Aedes aegypti and their association with insecticide resistance. Med Vet Entomol. 1993 Jan;7(1):11-6.

The enzymes acetylcholinesterase, glutathione S-transferase (GST), glucose 6-phosphate dehydrogenase (G6PD), and general esterases were assayed in four strains of Aedes aegypti mosquitoes aged between 1 and 30 days.
Insecticide bioassays showed that two strains (Trinidad and Virtudes) of Ae. aegypti were resistant to DDT, deltamethrin and malathion, whereas two other strains (Bangkok and Indian) were susceptible to all four classes of insecticides tested.
1(0,0,0,1) Details
7572467 Mourya DT, Hemingway J, Leake CJ: Post-inoculation changes in enzyme activity of Aedes aegypti infected with Chikungunya virus. Acta Virol. 1995 Feb;39(1):31-5.

Levels of acetylcholinesterase, non-specific esterases, glutathione-S-transferase and glucose-6-phosphate dehydrogenase in Aedes aegypti (L.) mosquitoes inoculated intrathoracally with Chikungunya virus were elevated, as compared to uninoculated control insects.
Malathion bioassays indicated a reduction in the susceptibility of experimentally injected insects with virus or virus-free inoculum, compared to non-inoculated controls.
1(0,0,0,1) Details