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Myshkin VA, Guliaeva IA, Ibatullina RB, Savlukov AI, Enikeev DA, Sergeeva SA: [The influence of the actoprotectors on lipid peroxidation and erythrocyte membranes in rats poisoned with malathion ]. Patol Fiziol Eksp Ter. 2004 Jul-Sep;(3):10-2.
Actoprotecting properties ofbemitil, tietasol in combination with atropin were studied in red cell membranes and lipid peroxidation of rats poisoned with MI in a dose 320 mg/kg (0.9 LD50). Atropin treatment showed a low effect. The addition of bemitil and tietasol normalized electric charge and osmotic resistance in red cell membranes, activity of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase and content of lipid peroxidation products--ketodienes and TBA-reacting products. Efficacy of the combined treatment is due primarily to noncholinergic mechanism of action of bemitil and tietasol--stimulation of endogenic antioxidant systems of erythron and antiradical activity (bemitil). |
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