| Name | epoxide hydrolase |
|---|---|
| Synonyms | EPHX; EPHX 1; EPHX1; EPHX1 protein; EPOX; Epoxide hydratase; Epoxide hydrolase; Epoxide hydrolase 1… |
| Name | malathion |
|---|---|
| CAS | diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3629631 | Reidy GF, Rose HA, Stacey NH: Effect of length of exposure to malathion on xenobiotic biotransformation in male rat liver. Toxicol Lett. 1987 Sep;38(1-2):193-9. Groups of rats dosed i.p. daily for 1 or 2 weeks with 40 or 200 mg/kg malathion showed an increase in epoxide hydrolase activity (1 week, 200 mg/kg) and glutathione S-transferase activity (1 week, 200 mg/kg; 2 weeks 40 and 200 mg/kg). |
12(0,0,2,2) | Details |
| 3488742 | Koizumi A, Hasegawa L, Thomas IK, Imamura T: Effect of induction of T-cell-dependent antibody with sheep red blood cells on P-450-dependent and -independent xenobiotic metabolizing enzymes. Biochem Pharmacol. 1986 Aug 15;35(16):2743-8. Similarly, the difference due to the strain and the H-2 locus was detected in the activities of P-450-independent enzymes such as malathion and diethyl carboxylesterases, glutathione S-transferase, and epoxide hydrolases in microsomal and cytosolic fractions. |
6(0,0,1,1) | Details |
| 6298443 | Dauterman WC: The role of hydrolases in insecticide metabolism and the toxicological significance of the metabolites. J Toxicol Clin Toxicol. 1982 Aug;19(6-7):623-35. The hydrolytic enzymes involved in insecticide metabolism are the phosphorotriester hydrolases, carboxylesterases, carboxylamidases and epoxide hydrolases. Carboxylesterases hydrolyze the carboethoxy group of malathion and also have hydrolytic activity toward certain synthetic pyrethroids. |
2(0,0,0,2) | Details |