| Name | liver carboxylesterase |
|---|---|
| Synonyms | ACAT; Cholesteryl ester hydrolase; CES1; SES 1; SES1; ANAE; Acid esterase; Acyl coenzyme A cholesterol acyltransferase… |
| Name | malathion |
|---|---|
| CAS | diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3434778 | Ashour MB, Gee SJ, Hammock BD: Use of a 96-well microplate reader for measuring routine enzyme activities. Anal Biochem. 1987 Nov 1;166(2):353-60. Examples include monitorings of the rate of hydrolysis of acetylthiocholine iodide by eel acetylcholinesterase and the rate of hydrolysis of malathion and nonconventional esters such as O-methyl, O-ethyl, and O-isobutyl carbonates of by commercial porcine liver carboxylesterase. |
6(0,0,1,1) | Details |
| 8321828 | Huang TL, Szekacs A, Uematsu T, Kuwano E, Parkinson A, Hammock BD: Hydrolysis of carbonates, thiocarbonates, carbamates, and carboxylic esters of alpha-naphthol, beta-naphthol, and by human, rat, and mouse liver carboxylesterases. Pharm Res. 1993 May;10(5):639-48. Malathion was a 15-fold better substrate for hydrolase B than for hydrolase A. |
2(0,0,0,2) | Details |
| 6639686 | Imamura T, Gandy J, Fukuto TR: Selective inhibition of rat pulmonary monooxygenase by O,O,S-trimethyl phosphorothioate treatment. Biochem Pharmacol. 1983 Nov 1;32(21):3191-5. In contrast, a dose-dependent decrease was observed in the liver carboxylesterase. Pulmonary malathion carboxylesterase activity was not affected by OOS treatment. |
1(0,0,0,1) | Details |
| 3593399 | Ashour MB, Hammock BD: Substituted trifluoroketones as potent, selective inhibitors of mammalian carboxylesterases. Biochem Pharmacol. 1987 Jun 15;36(12):1869-79. A series of substituted trifluoroketones were tested as inhibitors of mammalian liver microsomal carboxylesterase (s) hydrolyzing a variety of substrates including malathion, diethylsuccinate (DES) and p-nitrophenyl (p-NpAc). The trifluoroketones used were very potent "transition state" inhibitors of crude mouse and human liver microsomal carboxylesterases as well as commercial porcine liver carboxylesterase (Sigma EC 3.1.1.1 Type I). |
1(0,0,0,1) | Details |
| 7420466 | Mallipudi NM, Talcott RE, Ketterman A, Fukuto TR: Properties and inhibition of rat malathion carboxylesterases. J Toxicol Environ Health. 1980 May;6(3):585-96. Isomalathion appeared to be equipotent in inhibiting the rat liver carboxylesterase-catalyzed reactions leading to either alpha or beta-monoacid. |
1(0,0,0,1) | Details |
| 6642106 | Costa LG, Murphy SD: Unidirectional cross-tolerance between the insecticide propoxur and the organophosphate disulfoton in mice. Fundam Appl Toxicol. 1983 Sep-Oct;3(5):483-8. While hepatic microsomal enzymes appeared to be unchanged in disulfoton-tolerant mice, brain and liver carboxylesterase activities were significantly inhibited. The acute toxicity of the organophosphate malathion was also increased in disulfoton-tolerant mice. |
1(0,0,0,1) | Details |