| Name | glutathione reductase |
|---|---|
| Synonyms | GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases… |
| Name | malathion |
|---|---|
| CAS | diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10888576 | Yoshii K, Tsumura Y, Ishimitsu S, Tonogai Y, Nakamuro K: Degradation of malathion and phenthoate by glutathione reductase in wheat germ. J Agric Food Chem. 2000 Jun;48(6):2502-5. |
162(2,2,2,2) | Details |
| 17327255 | Brocardo PS, Assini F, Franco JL, Pandolfo P, Muller YM, Takahashi RN, Dafre AL, Rodrigues AL: attenuates malathion-induced depressant-like behavior and confers neuroprotection in the rat brain. Toxicol Sci. 2007 May;97(1):140-8. Epub 2007 Feb 27. Malathion (50 mg/kg, ip) alone caused some harmful effects, such as (1) an increase in lipid peroxidation and a reduction of peroxidase activity in the cerebral cortex, (2) reduction of glutathione reductase activity in the hippocampus, and (3) changes in the structure of chromatin in the dentate gyrus, all effects attenuated by ZnCl2. |
81(1,1,1,1) | Details |
| 18341513 | Trevisan R, Uliano-Silva M, Pandolfo P, Franco JL, Brocardo PS, Santos AR, Farina M, Rodrigues AL, Takahashi RN, Dafre AL: Antioxidant and acetylcholinesterase response to repeated malathion exposure in rat cerebral cortex and hippocampus. Basic Clin Pharmacol Toxicol. 2008 Apr;102(4):365-9. Besides AChE inhibition, malathion may act as a pro-oxidative agent by interfering with antioxidant defences, as shown by a decrease of peroxidase and glutathione reductase activity in the cerebral cortex (100 mg/kg malathion). |
31(0,1,1,1) | Details |
| 19429256 | Franco JL, Posser T, Mattos JJ, Trevisan R, Brocardo PS, Rodrigues AL, Leal RB, Farina M, Marques MR, Bainy AC, Dafre AL: reverses malathion-induced impairment in antioxidant defenses. Toxicol Lett. 2009 Jun 22;187(3):137-43. Epub 2009 Mar 4. Malathion produced a significant decrease in hippocampal acetylcholinesterase, as well as a decrease in the activity of several hippocampal antioxidant enzymes: glutathione reductase, glutathione S-transferase, catalase and superoxide dismutase. |
6(0,0,1,1) | Details |
| 10762730 | Ahmed RS, Seth V, Pasha ST, Banerjee BD: Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats. Food Chem Toxicol. 2000 May;38(5):443-50. Administration of malathion (20 ppm) for 4 weeks increased the malondialdehyde (MDA) levels in serum, activities of superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx) in erythrocytes and glutathione reductase (GR) and glutathione S-transferase (GST) in serum. |
6(0,0,1,1) | Details |
| 16716398 | da Silva AP, Meotti FC, Santos AR, Farina M: Lactational exposure to malathion inhibits brain acetylcholinesterase in mice. Neurotoxicology. 2006 Dec;27(6):1101-5. Epub 2006 Apr 28. In this study, we investigated the exclusive contribution of malathion exposure through maternal milk on the activity of acetylcholinesterase (AChE), as well as on biochemical parameters related to the oxidative stress levels, lipid peroxidation and glutathione reductase and peroxidase activities) in the brain of suckling mice. |
6(0,0,1,1) | Details |
| 18035420 | da Silva AP, Farina M, Franco JL, Dafre AL, Kassa J, Kuca K: Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex. Neurotoxicology. 2008 Jan;29(1):184-9. Epub 2007 Oct 18. Acetylcholinesterase activity and biochemical parameters related to oxidative stress levels, peroxidase and glutathione reductase activity and lipid peroxidation) were evaluated in mouse prefrontal cortex at two different time points (3 or 24 h after malathion poisoning). |
6(0,0,1,1) | Details |
| 8288844 | Chhabra SK, Hashim S, Rao AR: Modulation of hepatic system of enzymes in suckling mouse pups exposed translactationally to malathion. J Appl Toxicol. 1993 Nov-Dec;13(6):411-6. A significant enhancement in glutathione reductase activity was observed with malathion treatment in livers of dams and pups (P < 0.001). |
6(0,0,1,1) | Details |
| 15596258 | Brocardo PS, Pandolfo P, Takahashi RN, Rodrigues AL, Dafre AL: Antioxidant defenses and lipid peroxidation in the cerebral cortex and hippocampus following acute exposure to malathion and/or zinc Toxicology. 2005 Feb 14;207(2):283-91. This study investigates the effects of acute exposure to organophosphate insecticide malathion (250 mg/kg, i.p.) and/or ZnCl2 (5 mg/kg, i.p.), with the following parameters: lipid peroxidation and the activity of acetylcholinesterase (AChE), glutathione reductase (GR), glutathione S-transferase (GST), peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PDH), and the levels of total (GSH-t) in the hippocampus and cerebral cortex of female rats. |
6(0,0,1,1) | Details |
| 19051277 | Huculeci R, Dinu D, Staicu AC, Munteanu MC, Costache M, Dinischiotu A: Malathion-induced alteration of the antioxidant defence system in kidney, gill, and intestine of Carassius auratus gibelio. Environ Toxicol. 2009 Dec;24(6):523-30. The modulation in the activities of antioxidant enzymes, catalase, gluthatione peroxidase, glutathione reductase, and glutathione-S-transferase was time and tissue specific. |
1(0,0,0,1) | Details |