Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
8713423 Myshkin VA, Bakhtizina GZ, Bashkatov SA, Varlamova TI, Volkova ES, Enikeev DA: [The correction of post-poisoning damages to the myocardium caused by carbophos]. 246.

Lipid peroxidation processes and levels of oxidative metabolism enzymes succinate and lactate dehydrogenases, as well as morphometric parameters of cardiomyocytes were studied in rats after exposure to malathion.
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19941925 Kalender S, Uzun FG, Durak D, Demir F, Kalender Y: Malathion-induced hepatotoxicity in rats: the effects of vitamins C and E. Food Chem Toxicol. 2010 Feb;48(2):633-8. Epub 2009 Nov 23.

Compared to the control group, the two groups also had significantly higher serum total cholesterol, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels, and significantly lower triglyceride and very low density lipoprotein (VLDL) levels.
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6657721 Francesconi R, Hubbard R, Mager M: Malathion administration: effects on physiological and physical performance in the heat. Anesteziol Reanimatol. 1995 Nov-Dec;(6):54

While creatine phosphokinase levels were unaffected by either cholinesterase inhibition or exercise in the heat, lactate dehydrogenase activities were increased (p less than 0.01) in both groups following hyperthermic exhaustion.
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4009736 Imamura T, Gandy J, Hasegawa L: Development of tolerance to a pneumotoxic impurity of malathion. . J Toxicol Environ Health. 1985;15(2):279-91.

OOS-Me produces morphological alteration of bronchiolar epithelial Clara cells accompanied by an increase in pulmonary lavage lactate dehydrogenase activity and severe weight loss in rats.
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12600110 Yang Y, Zhou M, Zhang H, Mao Y, Guo M: [Effects of isocarbophos on the integrity of epidermic cell membrane of human skin]. Hua Xi Yi Ke Da Xue Xue Bao. 2001 Jun;32(2):286-7


The activity of lactate dehydrogenase (LDH) was used as an indicator.
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6829031 Imamura T, Gandy J, Fukuto TR, Talbot P: An impurity of malathion alters the morphology of rat lung bronchiolar epithelium. Toxicology. 1983 Jan;26(1):73-9.

Moreover, lactate dehydrogenase (LDH) activity in bronchopulmonary lavage fluid was significantly higher in OOS than in control rats.
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15036745 Olgun S, Gogal RM Jr, Adeshina F, Choudhury H, Misra HP: Pesticide mixtures potentiate the toxicity in murine thymocytes. Toxicology. 2004 Mar 15;196(3):181-95.

C57BL/6 mouse thymocytes were exposed to lindane, malathion, and permethrin, either separately or in mixtures of two pesticides, in vitro.
These pesticide exposures caused both apoptotic and necrotic cell death in thymocytes as evaluated by flow cytometric analysis in combination with 7-aminoactinomycin-D (7-AAD), Annexin-V/propidium iodide (PI) staining assays and lactate dehydrogenase release assays.
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2095780 Matin MA, Sattar S, Husain K: Modification of malathion induced neurochemical changes by adrenalectomy in rats. Mol Chem Neuropathol. 1990 Aug-Oct;13(1-2):119-28.

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7444981 Chowdhury JS, Dudeja PK, Mehta SK, Mahmood A: Effect of a single oral dose of malathion on D-glucose and glycine uptake and on brush border enzymes in rat intestine. 56-7.

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3579975 Matin MA, Husain K: Cerebral glycogenolysis and glycolysis in malathion-treated hyperglycaemic animals. Biochem Pharmacol. 1987 Jun 1;36(11):1815-7.

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